KEGG   PATHWAY: hsa05166Help
Entry
hsa05166                    Pathway                                

Name
HTLV-I infection - Homo sapiens (human)
Description
Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, SRF, and NFAT.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
HTLV-I infection
hsa05166

All organismsOrtholog table
Disease
H00009  
Adult T-cell leukemia
Organism
Homo sapiens (human) [GN:hsa]
Gene
7040  
TGFB1; transforming growth factor, beta 1 [KO:K13375]
7042  
TGFB2; transforming growth factor, beta 2 [KO:K13376]
7043  
TGFB3; transforming growth factor, beta 3 [KO:K13377]
6513  
SLC2A1; solute carrier family 2 (facilitated glucose transporter), member 1 [KO:K07299]
8829  
NRP1; neuropilin 1 [KO:K06724]
7412  
VCAM1; vascular cell adhesion molecule 1 [KO:K06527]
915  
CD3D; CD3d molecule, delta (CD3-TCR complex) [KO:K06450]
916  
CD3E; CD3e molecule, epsilon (CD3-TCR complex) [KO:K06451]
917  
CD3G; CD3g molecule, gamma (CD3-TCR complex) [KO:K06452]
3383  
ICAM1; intercellular adhesion molecule 1 [KO:K06490]
3683  
ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1 [KO:K05718]
3689  
ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) [KO:K06464]
7094  
TLN1; talin 1 [KO:K06271]
83660  
TLN2; talin 2 [KO:K06271]
4609  
MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
8295  
TRRAP; transformation/transcription domain-associated protein [KO:K08874]
10524  
KAT5; K(lysine) acetyltransferase 5 [KO:K11304] [EC:2.3.1.48]
894  
CCND2; cyclin D2 [KO:K10151]
8498  
RANBP3; RAN binding protein 3 [KO:K15304]
5901  
RAN; RAN, member RAS oncogene family [KO:K07936]
7514  
XPO1; exportin 1 [KO:K14290]
3105  
HLA-A; major histocompatibility complex, class I, A [KO:K06751]
3106  
HLA-B; major histocompatibility complex, class I, B [KO:K06751]
3107  
HLA-C; major histocompatibility complex, class I, C [KO:K06751]
3134  
HLA-F; major histocompatibility complex, class I, F [KO:K06751]
3135  
HLA-G; major histocompatibility complex, class I, G [KO:K06751]
3133  
HLA-E; major histocompatibility complex, class I, E [KO:K06751]
811  
CALR; calreticulin [KO:K08057]
5530  
PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme [KO:K04348] [EC:3.1.3.16]
5532  
PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme [KO:K04348] [EC:3.1.3.16]
5533  
PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme [KO:K04348] [EC:3.1.3.16]
5534  
PPP3R1; protein phosphatase 3, regulatory subunit B, alpha [KO:K06268]
5535  
PPP3R2; protein phosphatase 3, regulatory subunit B, beta [KO:K06268]
4772  
NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 [KO:K04446]
4773  
NFATC2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 [KO:K17332]
4775  
NFATC3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 [KO:K17333]
4776  
NFATC4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 [KO:K17334]
821  
CANX; calnexin [KO:K08054]
3560  
IL2RB; interleukin 2 receptor, beta [KO:K05069]
3561  
IL2RG; interleukin 2 receptor, gamma [KO:K05070]
3716  
JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
3718  
JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
6776  
STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
6777  
STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
2224  
FDPS; farnesyl diphosphate synthase [KO:K00787] [EC:2.5.1.10 2.5.1.1]
3265  
HRAS; Harvey rat sarcoma viral oncogene homolog [KO:K02833]
3845  
KRAS; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
4893  
NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
6237  
RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
22800  
RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
22808  
MRAS; muscle RAS oncogene homolog [KO:K07831]
7416  
VDAC1; voltage-dependent anion channel 1 [KO:K05862]
291  
SLC25A4; solute carrier family 25 (mitochondrial carrier [KO:K05863]
292  
SLC25A5; solute carrier family 25 (mitochondrial carrier [KO:K05863]
293  
SLC25A6; solute carrier family 25 (mitochondrial carrier [KO:K05863]
83447  
SLC25A31; solute carrier family 25 (mitochondrial carrier [KO:K05863]
7417  
VDAC2; voltage-dependent anion channel 2 [KO:K15040]
7419  
VDAC3; voltage-dependent anion channel 3 [KO:K15041]
706  
TSPO; translocator protein (18kDa) [KO:K05770]
55697  
VAC14; Vac14 homolog (S. cerevisiae) [KO:K15305]
5902  
RANBP1; RAN binding protein 1 [KO:K15306]
4085  
MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast) [KO:K02537]
701  
BUB1B; BUB1 mitotic checkpoint serine/threonine kinase B [KO:K06637] [EC:2.7.11.1]
9184  
BUB3; BUB3 mitotic checkpoint protein [KO:K02180]
991  
CDC20; cell division cycle 20 [KO:K03363]
64682  
ANAPC1; anaphase promoting complex subunit 1 [KO:K03348]
29882  
ANAPC2; anaphase promoting complex subunit 2 [KO:K03349]
996  
CDC27; cell division cycle 27 [KO:K03350]
29945  
ANAPC4; anaphase promoting complex subunit 4 [KO:K03351]
51433  
ANAPC5; anaphase promoting complex subunit 5 [KO:K03352]
8881  
CDC16; cell division cycle 16 [KO:K03353]
51434  
ANAPC7; anaphase promoting complex subunit 7 [KO:K03354]
8697  
CDC23; cell division cycle 23 [KO:K03355]
10393  
ANAPC10; anaphase promoting complex subunit 10 [KO:K03357]
51529  
ANAPC11; anaphase promoting complex subunit 11 [KO:K03358]
246184  
CDC26; cell division cycle 26 [KO:K03359]
9232  
PTTG1; pituitary tumor-transforming 1 [KO:K06635]
10744  
PTTG2; pituitary tumor-transforming 2 [KO:K06635]
1026  
CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) [KO:K06625]
5111  
PCNA; proliferating cell nuclear antigen [KO:K04802]
5424  
POLD1; polymerase (DNA directed), delta 1, catalytic subunit [KO:K02327] [EC:2.7.7.7]
5425  
POLD2; polymerase (DNA directed), delta 2, accessory subunit [KO:K02328]
10714  
POLD3; polymerase (DNA-directed), delta 3, accessory subunit [KO:K03504]
57804  
POLD4; polymerase (DNA-directed), delta 4, accessory subunit [KO:K03505]
5426  
POLE; polymerase (DNA directed), epsilon, catalytic subunit [KO:K02324] [EC:2.7.7.7]
5427  
POLE2; polymerase (DNA directed), epsilon 2, accessory subunit [KO:K02325] [EC:2.7.7.7]
54107  
POLE3; polymerase (DNA directed), epsilon 3, accessory subunit [KO:K02326] [EC:2.7.7.7]
56655  
POLE4; polymerase (DNA-directed), epsilon 4, accessory subunit [KO:K03506] [EC:2.7.7.7]
595  
CCND1; cyclin D1 [KO:K04503]
896  
CCND3; cyclin D3 [KO:K10152]
1019  
CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
5925  
RB1; retinoblastoma 1 [KO:K06618]
1869  
E2F1; E2F transcription factor 1 [KO:K17454]
1870  
E2F2; E2F transcription factor 2 [KO:K09389]
1871  
E2F3; E2F transcription factor 3 [KO:K06620]
1029  
CDKN2A; cyclin-dependent kinase inhibitor 2A [KO:K06621]
1030  
CDKN2B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) [KO:K04685]
7471  
WNT1; wingless-type MMTV integration site family, member 1 [KO:K03209]
7472  
WNT2; wingless-type MMTV integration site family member 2 [KO:K00182]
7482  
WNT2B; wingless-type MMTV integration site family, member 2B [KO:K00182]
7473  
WNT3; wingless-type MMTV integration site family, member 3 [KO:K00312]
89780  
WNT3A; wingless-type MMTV integration site family, member 3A [KO:K00312]
54361  
WNT4; wingless-type MMTV integration site family, member 4 [KO:K00408]
7474  
WNT5A; wingless-type MMTV integration site family, member 5A [KO:K00444]
81029  
WNT5B; wingless-type MMTV integration site family, member 5B [KO:K00444]
7475  
WNT6; wingless-type MMTV integration site family, member 6 [KO:K00445]
7476  
WNT7A; wingless-type MMTV integration site family, member 7A [KO:K00572]
7477  
WNT7B; wingless-type MMTV integration site family, member 7B [KO:K00572]
7478  
WNT8A; wingless-type MMTV integration site family, member 8A [KO:K00714]
7479  
WNT8B; wingless-type MMTV integration site family, member 8B [KO:K00714]
7483  
WNT9A; wingless-type MMTV integration site family, member 9A [KO:K01064]
7484  
WNT9B; wingless-type MMTV integration site family, member 9B [KO:K01064]
7480  
WNT10B; wingless-type MMTV integration site family, member 10B [KO:K01357]
80326  
WNT10A; wingless-type MMTV integration site family, member 10A [KO:K01357]
7481  
WNT11; wingless-type MMTV integration site family, member 11 [KO:K01384]
51384  
WNT16; wingless-type MMTV integration site family, member 16 [KO:K01558]
8321  
FZD1; frizzled class receptor 1 [KO:K02432]
8324  
FZD7; frizzled class receptor 7 [KO:K02432]
2535  
FZD2; frizzled class receptor 2 [KO:K02235]
7976  
FZD3; frizzled class receptor 3 [KO:K02329]
8322  
FZD4; frizzled class receptor 4 [KO:K02354]
7855  
FZD5; frizzled class receptor 5 [KO:K02375]
8325  
FZD8; frizzled class receptor 8 [KO:K02375]
8323  
FZD6; frizzled class receptor 6 [KO:K02376]
11211  
FZD10; frizzled class receptor 10 [KO:K02842]
8326  
FZD9; frizzled class receptor 9 [KO:K02842]
1857  
DVL3; dishevelled segment polarity protein 3 [KO:K02353]
1856  
DVL2; dishevelled segment polarity protein 2 [KO:K02353]
1855  
DVL1; dishevelled segment polarity protein 1 [KO:K02353]
2932  
GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
1499  
CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa [KO:K02105]
324  
APC; adenomatous polyposis coli [KO:K02085]
10297  
APC2; adenomatosis polyposis coli 2 [KO:K02085]
1739  
DLG1; discs, large homolog 1 (Drosophila) [KO:K12076]
5154  
PDGFA; platelet-derived growth factor alpha polypeptide [KO:K04359]
5155  
PDGFB; platelet-derived growth factor beta polypeptide [KO:K17386]
5156  
PDGFRA; platelet-derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
5159  
PDGFRB; platelet-derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
5295  
PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
23533  
PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
5296  
PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
8503  
PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO:K02649]
5290  
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294  
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
207  
AKT1; v-akt murine thymoma viral oncogene homolog 1 [KO:K04456] [EC:2.7.11.1]
208  
AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
10000  
AKT3; v-akt murine thymoma viral oncogene homolog 3 [KO:K04456] [EC:2.7.11.1]
7124  
TNF; tumor necrosis factor [KO:K03156]
7132  
TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A [KO:K03158]
4214  
MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase [KO:K04416] [EC:2.7.11.25]
6416  
MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
3725  
JUN; jun proto-oncogene [KO:K04448]
2874  
GPS2; G protein pathway suppressor 2 [KO:K15307]
3554  
IL1R1; interleukin 1 receptor, type I [KO:K04386]
7850  
IL1R2; interleukin 1 receptor, type II [KO:K04387]
4215  
MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
1147  
CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
3551  
IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
8517  
IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [KO:K07210]
4792  
NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [KO:K04734]
4790  
NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
5970  
RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A [KO:K04735]
4055  
LTBR; lymphotoxin beta receptor (TNFR superfamily, member 3) [KO:K03159]
958  
CD40; CD40 molecule, TNF receptor superfamily member 5 [KO:K03160]
115650  
TNFRSF13C; tumor necrosis factor receptor superfamily, member 13C [KO:K05151]
9020  
MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
5971  
RELB; v-rel avian reticuloendotheliosis viral oncogene homolog B [KO:K09253]
4791  
NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) [KO:K04469]
3558  
IL2; interleukin 2 [KO:K05429]
3559  
IL2RA; interleukin 2 receptor, alpha [KO:K05068]
3600  
IL15; interleukin 15 [KO:K05433]
3601  
IL15RA; interleukin 15 receptor, alpha [KO:K05074]
3569  
IL6; interleukin 6 [KO:K05405]
1437  
CSF2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427]
4049  
LTA; lymphotoxin alpha [KO:K05468]
598  
BCL2L1; BCL2-like 1 [KO:K04570]
331  
XIAP; X-linked inhibitor of apoptosis [KO:K04725]
7538  
ZFP36; ZFP36 ring finger protein [KO:K15308]
4801  
NFYB; nuclear transcription factor Y, beta [KO:K08065]
3108  
HLA-DMA; major histocompatibility complex, class II, DM alpha [KO:K06752]
3109  
HLA-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
3111  
HLA-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
3112  
HLA-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
3113  
HLA-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
3115  
HLA-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
3117  
HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
3118  
HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
3119  
HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
3122  
HLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
3123  
HLA-DRB1; major histocompatibility complex, class II, DR beta 1 [KO:K06752]
3125  
HLA-DRB3; major histocompatibility complex, class II, DR beta 3 [KO:K06752]
3126  
HLA-DRB4; major histocompatibility complex, class II, DR beta 4 [KO:K06752]
3127  
HLA-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
6722  
SRF; serum response factor (c-fos serum response element-binding transcription factor) [KO:K04378]
2005  
ELK4; ELK4, ETS-domain protein (SRF accessory protein 1) [KO:K04376]
2002  
ELK1; ELK1, member of ETS oncogene family [KO:K04375]
6688  
SPI1; Spi-1 proto-oncogene [KO:K09438]
2113  
ETS1; v-ets avian erythroblastosis virus E26 oncogene homolog 1 [KO:K02678]
2114  
ETS2; v-ets avian erythroblastosis virus E26 oncogene homolog 2 [KO:K02678]
387332  
TBPL2; TATA box binding protein like 2 [KO:K03120]
9519  
TBPL1; TBP-like 1 [KO:K03120]
6908  
TBP; TATA box binding protein [KO:K03120]
2353  
FOS; FBJ murine osteosarcoma viral oncogene homolog [KO:K04379]
1958  
EGR1; early growth response 1 [KO:K09203]
1959  
EGR2; early growth response 2 [KO:K12496]
8061  
FOSL1; FOS-like antigen 1 [KO:K04502]
107  
ADCY1; adenylate cyclase 1 (brain) [KO:K08041] [EC:4.6.1.1]
108  
ADCY2; adenylate cyclase 2 (brain) [KO:K08042] [EC:4.6.1.1]
109  
ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
196883  
ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
111  
ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
112  
ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
113  
ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
114  
ADCY8; adenylate cyclase 8 (brain) [KO:K08048] [EC:4.6.1.1]
115  
ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
5566  
PRKACA; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
5567  
PRKACB; protein kinase, cAMP-dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
5568  
PRKACG; protein kinase, cAMP-dependent, catalytic, gamma [KO:K04345] [EC:2.7.11.11]
5613  
PRKX; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
1385  
CREB1; cAMP responsive element binding protein 1 [KO:K05870]
1390  
CREM; cAMP responsive element modulator [KO:K09052]
466  
ATF1; activating transcription factor 1 [KO:K09053]
1386  
ATF2; activating transcription factor 2 [KO:K04450]
467  
ATF3; activating transcription factor 3 [KO:K09032]
468  
ATF4; activating transcription factor 4 [KO:K04374]
7494  
XBP1; X-box binding protein 1 [KO:K09027]
23373  
CRTC1; CREB regulated transcription coactivator 1 [KO:K15309]
200186  
CRTC2; CREB regulated transcription coactivator 2 [KO:K16333]
64784  
CRTC3; CREB regulated transcription coactivator 3 [KO:K16334]
1387  
CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
2033  
EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
8850  
KAT2B; K(lysine) acetyltransferase 2B [KO:K06062] [EC:2.3.1.48]
2648  
KAT2A; K(lysine) acetyltransferase 2A [KO:K06062] [EC:2.3.1.48]
6929  
TCF3; transcription factor 3 [KO:K09063]
5423  
POLB; polymerase (DNA directed), beta [KO:K02330] [EC:4.2.99.- 2.7.7.7]
1031  
CDKN2C; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) [KO:K06622]
3932  
LCK; LCK proto-oncogene, Src family tyrosine kinase [KO:K05856] [EC:2.7.10.2]
7015  
TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
4602  
MYB; v-myb avian myeloblastosis viral oncogene homolog [KO:K09420]
4603  
MYBL1; v-myb avian myeloblastosis viral oncogene homolog-like 1 [KO:K09421]
4605  
MYBL2; v-myb avian myeloblastosis viral oncogene homolog-like 2 [KO:K09421]
7046  
TGFBR1; transforming growth factor, beta receptor 1 [KO:K04674] [EC:2.7.11.30]
7048  
TGFBR2; transforming growth factor, beta receptor II (70/80kDa) [KO:K04388] [EC:2.7.11.30]
4087  
SMAD2; SMAD family member 2 [KO:K04500]
4088  
SMAD3; SMAD family member 3 [KO:K04500]
4089  
SMAD4; SMAD family member 4 [KO:K04501]
472  
ATM; ATM serine/threonine kinase [KO:K04728] [EC:2.7.11.1]
545  
ATR; ATR serine/threonine kinase [KO:K06640] [EC:2.7.11.1]
1111  
CHEK1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
11200  
CHEK2; checkpoint kinase 2 [KO:K06641] [EC:2.7.11.1]
7157  
TP53; tumor protein p53 [KO:K04451]
581  
BAX; BCL2-associated X protein [KO:K02159]
94241  
TP53INP1; tumor protein p53 inducible nuclear protein 1 [KO:K15310]
4487  
MSX1; msh homeobox 1 [KO:K09341]
4488  
MSX2; msh homeobox 2 [KO:K09341]
5599  
MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
9133  
CCNB2; cyclin B2 [KO:K05868]
Compound
C00027  
Hydrogen peroxide
C00076  
Calcium cation
C00238  
Potassium cation
C00575  
3',5'-Cyclic AMP
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C18994  
Accessory protein p12I
C18995  
P13 protein
C18996  
Accessory protein p30II
C19313  
HTLV-1 basic zipper factor
Reference
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
Reference
  Authors
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