KEGG   PATHWAY: hsa05166Help
Entry
hsa05166                    Pathway                                

Name
HTLV-I infection - Homo sapiens (human)
Description
Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, SRF, and NFAT.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
HTLV-I infection
hsa05166

All organismsOrtholog table
Disease
H00009  
Adult T-cell leukemia
Organism
Homo sapiens (human) [GN:hsa]
Gene
7040  
K13375 transforming growth factor beta-1 | (RefSeq) TGFB1; transforming growth factor beta 1 [KO:K13375]
7042  
K13376 transforming growth factor beta-2 | (RefSeq) TGFB2; transforming growth factor beta 2 [KO:K13376]
7043  
K13377 transforming growth factor beta-3 | (RefSeq) TGFB3; transforming growth factor beta 3 [KO:K13377]
6513  
K07299 MFS transporter; solute carrier family 2 member 1 [KO:K07299]
8829  
K06724 neuropilin 1 | (RefSeq) NRP1; neuropilin 1 [KO:K06724]
7412  
K06527 vascular cell adhesion molecule 1 | (RefSeq) VCAM1; vascular cell adhesion molecule 1 [KO:K06527]
915  
K06450 T-cell surface glycoprotein CD3 delta chain | (RefSeq) CD3D; CD3d molecule [KO:K06450]
916  
K06451 T-cell surface glycoprotein CD3 epsilon chain | (RefSeq) CD3E; CD3e molecule [KO:K06451]
917  
K06452 T-cell surface glycoprotein CD3 gamma chain | (RefSeq) CD3G; CD3g molecule [KO:K06452]
3383  
K06490 intercellular adhesion molecule 1 | (RefSeq) ICAM1; intercellular adhesion molecule 1 [KO:K06490]
3683  
K05718 integrin alpha L | (RefSeq) ITGAL; integrin subunit alpha L [KO:K05718]
3689  
K06464 integrin beta 2 | (RefSeq) ITGB2; integrin subunit beta 2 [KO:K06464]
7094  
K06271 talin | (RefSeq) TLN1; talin 1 [KO:K06271]
83660  
K06271 talin | (RefSeq) TLN2; talin 2 [KO:K06271]
4609  
K04377 Myc proto-oncogene protein | (RefSeq) MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
8295  
K08874 transformation/transcription domain-associated protein | (RefSeq) TRRAP; transformation/transcription domain associated protein [KO:K08874]
10524  
K11304 histone acetyltransferase HTATIP [EC:2.3.1.48] | (RefSeq) KAT5; lysine acetyltransferase 5 [KO:K11304] [EC:2.3.1.48]
894  
K10151 cyclin D2 | (RefSeq) CCND2; cyclin D2 [KO:K10151]
8498  
K15304 Ran-binding protein 3 | (RefSeq) RANBP3; RAN binding protein 3 [KO:K15304]
5901  
K07936 GTP-binding nuclear protein Ran | (RefSeq) RAN; RAN, member RAS oncogene family [KO:K07936]
7514  
K14290 exportin-1 | (RefSeq) XPO1; exportin 1 [KO:K14290]
3105  
K06751 major histocompatibility complex; major histocompatibility complex, class I, A [KO:K06751]
3106  
K06751 major histocompatibility complex; major histocompatibility complex, class I, B [KO:K06751]
3107  
K06751 major histocompatibility complex; major histocompatibility complex, class I, C [KO:K06751]
3134  
K06751 major histocompatibility complex; major histocompatibility complex, class I, F [KO:K06751]
3135  
K06751 major histocompatibility complex; major histocompatibility complex, class I, G [KO:K06751]
3133  
K06751 major histocompatibility complex; major histocompatibility complex, class I, E [KO:K06751]
811  
K08057 calreticulin | (RefSeq) CALR; calreticulin [KO:K08057]
5530  
K04348 serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16] | (RefSeq) PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
5532  
K04348 serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16] | (RefSeq) PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
5533  
K04348 serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16] | (RefSeq) PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
5534  
K06268 serine/threonine-protein phosphatase 2B regulatory subunit | (RefSeq) PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
5535  
K06268 serine/threonine-protein phosphatase 2B regulatory subunit | (RefSeq) PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
4772  
K04446 nuclear factor of activated T-cells; nuclear factor of activated T-cells 1 [KO:K04446]
4773  
K17332 nuclear factor of activated T-cells; nuclear factor of activated T-cells 2 [KO:K17332]
4775  
K17333 nuclear factor of activated T-cells; nuclear factor of activated T-cells 3 [KO:K17333]
4776  
K17334 nuclear factor of activated T-cells; nuclear factor of activated T-cells 4 [KO:K17334]
821  
K08054 calnexin | (RefSeq) CANX; calnexin [KO:K08054]
3560  
K05069 interleukin 2 receptor beta | (RefSeq) IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
3561  
K05070 interleukin 2 receptor gamma | (RefSeq) IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
3716  
K11217 Janus kinase 1 [EC:2.7.10.2] | (RefSeq) JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
3718  
K11218 Janus kinase 3 [EC:2.7.10.2] | (RefSeq) JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
6776  
K11223 signal transducer and activator of transcription 5A | (RefSeq) STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
6777  
K11224 signal transducer and activator of transcription 5B | (RefSeq) STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
2224  
K00787 farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10] | (RefSeq) FDPS; farnesyl diphosphate synthase [KO:K00787] [EC:2.5.1.10 2.5.1.1]
3265  
K02833 GTPase HRas | (RefSeq) HRAS; HRas proto-oncogene, GTPase [KO:K02833]
3845  
K07827 GTPase KRas | (RefSeq) KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
4893  
K07828 GTPase NRas | (RefSeq) NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
6237  
K07829 Ras-related protein R-Ras | (RefSeq) RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
22800  
K07830 Ras-related protein R-Ras2 | (RefSeq) RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
22808  
K07831 Ras-related protein M-Ras | (RefSeq) MRAS; muscle RAS oncogene homolog [KO:K07831]
7416  
K05862 voltage-dependent anion channel protein 1 | (RefSeq) VDAC1; voltage dependent anion channel 1 [KO:K05862]
291  
K05863 solute carrier family 25 (mitochondrial adenine nucleotide translocator); solute carrier family 25 member 4 [KO:K05863]
292  
K05863 solute carrier family 25 (mitochondrial adenine nucleotide translocator); solute carrier family 25 member 5 [KO:K05863]
293  
K05863 solute carrier family 25 (mitochondrial adenine nucleotide translocator); solute carrier family 25 member 6 [KO:K05863]
83447  
K05863 solute carrier family 25 (mitochondrial adenine nucleotide translocator); solute carrier family 25 member 31 [KO:K05863]
7417  
K15040 voltage-dependent anion channel protein 2 | (RefSeq) VDAC2; voltage dependent anion channel 2 [KO:K15040]
7419  
K15041 voltage-dependent anion channel protein 3 | (RefSeq) VDAC3; voltage dependent anion channel 3 [KO:K15041]
706  
K05770 benzodiazapine receptor | (RefSeq) TSPO; translocator protein [KO:K05770]
55697  
K15305 vacuole morphology and inheritance protein 14 | (RefSeq) VAC14; Vac14, PIKFYVE complex component [KO:K15305]
5902  
K15306 Ran-binding protein 1 | (RefSeq) RANBP1; RAN binding protein 1 [KO:K15306]
4085  
K02537 mitotic spindle assembly checkpoint protein MAD2 | (RefSeq) MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast) [KO:K02537]
701  
K06637 mitotic checkpoint serine/threonine-protein kinase BUB1 beta [EC:2.7.11.1] | (RefSeq) BUB1B; BUB1 mitotic checkpoint serine/threonine kinase B [KO:K06637] [EC:2.7.11.1]
9184  
K02180 cell cycle arrest protein BUB3 | (RefSeq) BUB3; BUB3, mitotic checkpoint protein [KO:K02180]
991  
K03363 cell division cycle 20; cell division cycle 20 [KO:K03363]
64682  
K03348 anaphase-promoting complex subunit 1 | (RefSeq) ANAPC1; anaphase promoting complex subunit 1 [KO:K03348]
29882  
K03349 anaphase-promoting complex subunit 2 | (RefSeq) ANAPC2; anaphase promoting complex subunit 2 [KO:K03349]
996  
K03350 anaphase-promoting complex subunit 3 | (RefSeq) CDC27; cell division cycle 27 [KO:K03350]
29945  
K03351 anaphase-promoting complex subunit 4 | (RefSeq) ANAPC4; anaphase promoting complex subunit 4 [KO:K03351]
51433  
K03352 anaphase-promoting complex subunit 5 | (RefSeq) ANAPC5; anaphase promoting complex subunit 5 [KO:K03352]
8881  
K03353 anaphase-promoting complex subunit 6 | (RefSeq) CDC16; cell division cycle 16 [KO:K03353]
51434  
K03354 anaphase-promoting complex subunit 7 | (RefSeq) ANAPC7; anaphase promoting complex subunit 7 [KO:K03354]
8697  
K03355 anaphase-promoting complex subunit 8 | (RefSeq) CDC23; cell division cycle 23 [KO:K03355]
10393  
K03357 anaphase-promoting complex subunit 10 | (RefSeq) ANAPC10; anaphase promoting complex subunit 10 [KO:K03357]
51529  
K03358 anaphase-promoting complex subunit 11 | (RefSeq) ANAPC11; anaphase promoting complex subunit 11 [KO:K03358]
246184  
K03359 anaphase-promoting complex subunit 12 | (RefSeq) CDC26; cell division cycle 26 [KO:K03359]
9232  
K06635 securin | (RefSeq) PTTG1; pituitary tumor-transforming 1 [KO:K06635]
10744  
K06635 securin | (RefSeq) PTTG2; pituitary tumor-transforming 2 [KO:K06635]
1026  
K06625 cyclin-dependent kinase inhibitor 1A | (RefSeq) CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
5111  
K04802 proliferating cell nuclear antigen | (RefSeq) PCNA; proliferating cell nuclear antigen [KO:K04802]
5424  
K02327 DNA polymerase delta subunit 1 [EC:2.7.7.7] | (RefSeq) POLD1; DNA polymerase delta 1, catalytic subunit [KO:K02327] [EC:2.7.7.7]
5425  
K02328 DNA polymerase delta subunit 2 | (RefSeq) POLD2; DNA polymerase delta 2, accessory subunit [KO:K02328]
10714  
K03504 DNA polymerase delta subunit 3 | (RefSeq) POLD3; DNA polymerase delta 3, accessory subunit [KO:K03504]
57804  
K03505 DNA polymerase delta subunit 4 | (RefSeq) POLD4; DNA polymerase delta 4, accessory subunit [KO:K03505]
5426  
K02324 DNA polymerase epsilon subunit 1 [EC:2.7.7.7] | (RefSeq) POLE; DNA polymerase epsilon, catalytic subunit [KO:K02324] [EC:2.7.7.7]
5427  
K02325 DNA polymerase epsilon subunit 2 [EC:2.7.7.7] | (RefSeq) POLE2; DNA polymerase epsilon 2, accessory subunit [KO:K02325] [EC:2.7.7.7]
54107  
K02326 DNA polymerase epsilon subunit 3 [EC:2.7.7.7] | (RefSeq) POLE3; DNA polymerase epsilon 3, accessory subunit [KO:K02326] [EC:2.7.7.7]
56655  
K03506 DNA polymerase epsilon subunit 4 [EC:2.7.7.7] | (RefSeq) POLE4; DNA polymerase epsilon 4, accessory subunit [KO:K03506] [EC:2.7.7.7]
595  
K04503 cyclin D1 | (RefSeq) CCND1; cyclin D1 [KO:K04503]
896  
K10152 cyclin D3 | (RefSeq) CCND3; cyclin D3 [KO:K10152]
1019  
K02089 cyclin-dependent kinase 4 [EC:2.7.11.22] | (RefSeq) CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
5925  
K06618 retinoblastoma-associated protein | (RefSeq) RB1; RB transcriptional corepressor 1 [KO:K06618]
1869  
K17454 transcription factor E2F1 | (RefSeq) E2F1; E2F transcription factor 1 [KO:K17454]
1870  
K09389 transcription factor E2F2 | (RefSeq) E2F2; E2F transcription factor 2 [KO:K09389]
1871  
K06620 transcription factor E2F3 | (RefSeq) E2F3; E2F transcription factor 3 [KO:K06620]
1029  
K06621 cyclin-dependent kinase inhibitor 2A | (RefSeq) CDKN2A; cyclin dependent kinase inhibitor 2A [KO:K06621]
1030  
K04685 cyclin-dependent kinase inhibitor 2B | (RefSeq) CDKN2B; cyclin dependent kinase inhibitor 2B [KO:K04685]
7471  
K03209 wingless-type MMTV integration site family; Wnt family member 1 [KO:K03209]
7472  
K00182 wingless-type MMTV integration site family; Wnt family member 2 [KO:K00182]
7482  
K00182 wingless-type MMTV integration site family; Wnt family member 2B [KO:K00182]
7473  
K00312 wingless-type MMTV integration site family; Wnt family member 3 [KO:K00312]
89780  
K00312 wingless-type MMTV integration site family; Wnt family member 3A [KO:K00312]
54361  
K00408 wingless-type MMTV integration site family; Wnt family member 4 [KO:K00408]
7474  
K00444 wingless-type MMTV integration site family; Wnt family member 5A [KO:K00444]
81029  
K00444 wingless-type MMTV integration site family; Wnt family member 5B [KO:K00444]
7475  
K00445 wingless-type MMTV integration site family; Wnt family member 6 [KO:K00445]
7476  
K00572 wingless-type MMTV integration site family; Wnt family member 7A [KO:K00572]
7477  
K00572 wingless-type MMTV integration site family; Wnt family member 7B [KO:K00572]
7478  
K00714 wingless-type MMTV integration site family; Wnt family member 8A [KO:K00714]
7479  
K00714 wingless-type MMTV integration site family; Wnt family member 8B [KO:K00714]
7483  
K01064 wingless-type MMTV integration site family; Wnt family member 9A [KO:K01064]
7484  
K01064 wingless-type MMTV integration site family; Wnt family member 9B [KO:K01064]
7480  
K01357 wingless-type MMTV integration site family; Wnt family member 10B [KO:K01357]
80326  
K01357 wingless-type MMTV integration site family; Wnt family member 10A [KO:K01357]
7481  
K01384 wingless-type MMTV integration site family; Wnt family member 11 [KO:K01384]
51384  
K01558 wingless-type MMTV integration site family; Wnt family member 16 [KO:K01558]
8321  
K02432 frizzled 1/7 | (RefSeq) FZD1; frizzled class receptor 1 [KO:K02432]
8324  
K02432 frizzled 1/7 | (RefSeq) FZD7; frizzled class receptor 7 [KO:K02432]
2535  
K02235 frizzled 2 | (RefSeq) FZD2; frizzled class receptor 2 [KO:K02235]
7976  
K02329 frizzled 3 | (RefSeq) FZD3; frizzled class receptor 3 [KO:K02329]
8322  
K02354 frizzled 4 | (RefSeq) FZD4; frizzled class receptor 4 [KO:K02354]
7855  
K02375 frizzled 5/8 | (RefSeq) FZD5; frizzled class receptor 5 [KO:K02375]
8325  
K02375 frizzled 5/8 | (RefSeq) FZD8; frizzled class receptor 8 [KO:K02375]
8323  
K02376 frizzled 6 | (RefSeq) FZD6; frizzled class receptor 6 [KO:K02376]
11211  
K02842 frizzled 9/10 | (RefSeq) FZD10; frizzled class receptor 10 [KO:K02842]
8326  
K02842 frizzled 9/10 | (RefSeq) FZD9; frizzled class receptor 9 [KO:K02842]
1857  
K02353 segment polarity protein dishevelled | (RefSeq) DVL3; dishevelled segment polarity protein 3 [KO:K02353]
1856  
K02353 segment polarity protein dishevelled | (RefSeq) DVL2; dishevelled segment polarity protein 2 [KO:K02353]
1855  
K02353 segment polarity protein dishevelled | (RefSeq) DVL1; dishevelled segment polarity protein 1 [KO:K02353]
2932  
K03083 glycogen synthase kinase 3 beta [EC:2.7.11.26] | (RefSeq) GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
1499  
K02105 catenin beta 1 | (RefSeq) CTNNB1; catenin beta 1 [KO:K02105]
324  
K02085 adenomatosis polyposis coli protein | (RefSeq) APC; APC, WNT signaling pathway regulator [KO:K02085]
10297  
K02085 adenomatosis polyposis coli protein | (RefSeq) APC2; APC2, WNT signaling pathway regulator [KO:K02085]
1739  
K12076 disks large protein 1 | (RefSeq) DLG1; discs large MAGUK scaffold protein 1 [KO:K12076]
5154  
K04359 platelet-derived growth factor subunit A | (RefSeq) PDGFA; platelet derived growth factor subunit A [KO:K04359]
5155  
K17386 platelet-derived growth factor subunit B | (RefSeq) PDGFB; platelet derived growth factor subunit B [KO:K17386]
5156  
K04363 platelet-derived growth factor receptor alpha [EC:2.7.10.1] | (RefSeq) PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
5159  
K05089 platelet-derived growth factor receptor beta [EC:2.7.10.1] | (RefSeq) PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
5295  
K02649 phosphoinositide-3-kinase; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
23533  
K02649 phosphoinositide-3-kinase; phosphoinositide-3-kinase regulatory subunit 5 [KO:K02649]
5296  
K02649 phosphoinositide-3-kinase; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
8503  
K02649 phosphoinositide-3-kinase; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
5290  
K00922 phosphatidylinositol-4; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  
K00922 phosphatidylinositol-4; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  
K00922 phosphatidylinositol-4; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294  
K00922 phosphatidylinositol-4; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
207  
K04456 RAC serine/threonine-protein kinase [EC:2.7.11.1] | (RefSeq) AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
208  
K04456 RAC serine/threonine-protein kinase [EC:2.7.11.1] | (RefSeq) AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
10000  
K04456 RAC serine/threonine-protein kinase [EC:2.7.11.1] | (RefSeq) AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
7124  
K03156 tumor necrosis factor superfamily; tumor necrosis factor [KO:K03156]
7132  
K03158 tumor necrosis factor receptor superfamily member 1A | (RefSeq) TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
4214  
K04416 mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25] | (RefSeq) MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
6416  
K04430 mitogen-activated protein kinase kinase 4 [EC:2.7.12.2] | (RefSeq) MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
3725  
K04448 transcription factor AP-1 | (RefSeq) JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
2874  
K15307 G protein pathway suppressor 2 | (RefSeq) GPS2; G protein pathway suppressor 2 [KO:K15307]
3554  
K04386 interleukin 1 receptor type I | (RefSeq) IL1R1; interleukin 1 receptor type 1 [KO:K04386]
7850  
K04387 interleukin 1 receptor type II | (RefSeq) IL1R2; interleukin 1 receptor type 2 [KO:K04387]
4215  
K04421 mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25] | (RefSeq) MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
1147  
K04467 inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10] | (RefSeq) CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
3551  
K07209 inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10] | (RefSeq) IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
8517  
K07210 inhibitor of nuclear factor kappa-B kinase subunit gamma | (RefSeq) IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [KO:K07210]
4792  
K04734 NF-kappa-B inhibitor alpha | (RefSeq) NFKBIA; NFKB inhibitor alpha [KO:K04734]
4790  
K02580 nuclear factor NF-kappa-B p105 subunit | (RefSeq) NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
5970  
K04735 transcription factor p65 | (RefSeq) RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
4055  
K03159 lymphotoxin beta receptor TNFR superfamily member 3 | (RefSeq) LTBR; lymphotoxin beta receptor [KO:K03159]
958  
K03160 tumor necrosis factor receptor superfamily member 5 | (RefSeq) CD40; CD40 molecule [KO:K03160]
115650  
K05151 tumor necrosis factor receptor superfamily member 13C | (RefSeq) TNFRSF13C; TNF receptor superfamily member 13C [KO:K05151]
9020  
K04466 mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25] | (RefSeq) MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
5971  
K09253 transcription factor RelB | (RefSeq) RELB; RELB proto-oncogene, NF-kB subunit [KO:K09253]
4791  
K04469 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 | (RefSeq) NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
3558  
K05429 interleukin 2 | (RefSeq) IL2; interleukin 2 [KO:K05429]
3559  
K05068 interleukin 2 receptor alpha | (RefSeq) IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
3600  
K05433 interleukin 15 | (RefSeq) IL15; interleukin 15 [KO:K05433]
3601  
K05074 interleukin 15 receptor alpha | (RefSeq) IL15RA; interleukin 15 receptor subunit alpha [KO:K05074]
3569  
K05405 interleukin 6 | (RefSeq) IL6; interleukin 6 [KO:K05405]
1437  
K05427 granulocyte-macrophage colony-stimulating factor | (RefSeq) CSF2; colony stimulating factor 2 [KO:K05427]
4049  
K05468 lymphotoxin alpha (TNF superfamily; lymphotoxin alpha [KO:K05468]
598  
K04570 Bcl-2-like 1 (apoptosis regulator Bcl-X) | (RefSeq) BCL2L1; BCL2 like 1 [KO:K04570]
331  
K04725 E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27] | (RefSeq) XIAP; X-linked inhibitor of apoptosis [KO:K04725] [EC:2.3.2.27]
7538  
K15308 tristetraprolin | (RefSeq) ZFP36; ZFP36 ring finger protein [KO:K15308]
4801  
K08065 nuclear transcription Y subunit beta | (RefSeq) NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
3108  
K06752 major histocompatibility complex; major histocompatibility complex, class II, DM alpha [KO:K06752]
3109  
K06752 major histocompatibility complex; major histocompatibility complex, class II, DM beta [KO:K06752]
3111  
K06752 major histocompatibility complex; major histocompatibility complex, class II, DO alpha [KO:K06752]
3112  
K06752 major histocompatibility complex; major histocompatibility complex, class II, DO beta [KO:K06752]
3113  
K06752 major histocompatibility complex; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
3115  
K06752 major histocompatibility complex; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
3117  
K06752 major histocompatibility complex; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
3118  
K06752 major histocompatibility complex; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
3119  
K06752 major histocompatibility complex; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
3122  
K06752 major histocompatibility complex; major histocompatibility complex, class II, DR alpha [KO:K06752]
3123  
K06752 major histocompatibility complex; major histocompatibility complex, class II, DR beta 1 [KO:K06752]
3125  
K06752 major histocompatibility complex; major histocompatibility complex, class II, DR beta 3 [KO:K06752]
3126  
K06752 major histocompatibility complex; major histocompatibility complex, class II, DR beta 4 [KO:K06752]
3127  
K06752 major histocompatibility complex; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
6722  
K04378 serum response factor | (RefSeq) SRF; serum response factor [KO:K04378]
2005  
K04376 ETS domain-containing protein Elk-4 | (RefSeq) ELK4; ELK4, ETS transcription factor [KO:K04376]
2002  
K04375 ETS domain-containing protein Elk-1 | (RefSeq) ELK1; ELK1, ETS transcription factor [KO:K04375]
6688  
K09438 transcription factor PU.1 | (RefSeq) SPI1; Spi-1 proto-oncogene [KO:K09438]
2113  
K02678 C-ets | (RefSeq) ETS1; ETS proto-oncogene 1, transcription factor [KO:K02678]
2114  
K02678 C-ets | (RefSeq) ETS2; ETS proto-oncogene 2, transcription factor [KO:K02678]
387332  
K03120 transcription initiation factor TFIID TATA-box-binding protein | (RefSeq) TBPL2; TATA-box binding protein like 2 [KO:K03120]
9519  
K03120 transcription initiation factor TFIID TATA-box-binding protein | (RefSeq) TBPL1; TATA-box binding protein like 1 [KO:K03120]
6908  
K03120 transcription initiation factor TFIID TATA-box-binding protein | (RefSeq) TBP; TATA-box binding protein [KO:K03120]
2353  
K04379 proto-oncogene protein c-fos | (RefSeq) FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
1958  
K09203 early growth response protein 1 | (RefSeq) EGR1; early growth response 1 [KO:K09203]
1959  
K12496 early growth response protein 2 | (RefSeq) EGR2; early growth response 2 [KO:K12496]
8061  
K04502 fos-like antigen 1 | (RefSeq) FOSL1; FOS like 1, AP-1 transcription factor subunit [KO:K04502]
107  
K08041 adenylate cyclase 1 [EC:4.6.1.1] | (RefSeq) ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
108  
K08042 adenylate cyclase 2 [EC:4.6.1.1] | (RefSeq) ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
109  
K08043 adenylate cyclase 3 [EC:4.6.1.1] | (RefSeq) ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
196883  
K08044 adenylate cyclase 4 [EC:4.6.1.1] | (RefSeq) ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
111  
K08045 adenylate cyclase 5 [EC:4.6.1.1] | (RefSeq) ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
112  
K08046 adenylate cyclase 6 [EC:4.6.1.1] | (RefSeq) ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
113  
K08047 adenylate cyclase 7 [EC:4.6.1.1] | (RefSeq) ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
114  
K08048 adenylate cyclase 8 [EC:4.6.1.1] | (RefSeq) ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
115  
K08049 adenylate cyclase 9 [EC:4.6.1.1] | (RefSeq) ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
5566  
K04345 protein kinase A [EC:2.7.11.11] | (RefSeq) PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
5567  
K04345 protein kinase A [EC:2.7.11.11] | (RefSeq) PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
5568  
K04345 protein kinase A [EC:2.7.11.11] | (RefSeq) PRKACG; protein kinase cAMP-activated catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
1385  
K05870 cyclic AMP-responsive element-binding protein 1 | (RefSeq) CREB1; cAMP responsive element binding protein 1 [KO:K05870]
1390  
K09052 cAMP response element modulator | (RefSeq) CREM; cAMP responsive element modulator [KO:K09052]
466  
K09053 activating transcription factor 1 | (RefSeq) ATF1; activating transcription factor 1 [KO:K09053]
1386  
K04450 cyclic AMP-dependent transcription factor ATF-2 | (RefSeq) ATF2; activating transcription factor 2 [KO:K04450]
467  
K09032 activating transcription factor 3 | (RefSeq) ATF3; activating transcription factor 3 [KO:K09032]
468  
K04374 cyclic AMP-dependent transcription factor ATF-4 | (RefSeq) ATF4; activating transcription factor 4 [KO:K04374]
7494  
K09027 X box-binding protein 1 | (RefSeq) XBP1; X-box binding protein 1 [KO:K09027]
23373  
K15309 CREB-regulated transcription coactivator 1 | (RefSeq) CRTC1; CREB regulated transcription coactivator 1 [KO:K15309]
200186  
K16333 CREB-regulated transcription coactivator 2 | (RefSeq) CRTC2; CREB regulated transcription coactivator 2 [KO:K16333]
64784  
K16334 CREB-regulated transcription coactivator 3 | (RefSeq) CRTC3; CREB regulated transcription coactivator 3 [KO:K16334]
1387  
K04498 E1A/CREB-binding protein [EC:2.3.1.48] | (RefSeq) CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
2033  
K04498 E1A/CREB-binding protein [EC:2.3.1.48] | (RefSeq) EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
8850  
K06062 histone acetyltransferase [EC:2.3.1.48] | (RefSeq) KAT2B; lysine acetyltransferase 2B [KO:K06062] [EC:2.3.1.48]
2648  
K06062 histone acetyltransferase [EC:2.3.1.48] | (RefSeq) KAT2A; lysine acetyltransferase 2A [KO:K06062] [EC:2.3.1.48]
6929  
K09063 transcription factor E2-alpha | (RefSeq) TCF3; transcription factor 3 [KO:K09063]
5423  
K02330 DNA polymerase beta [EC:2.7.7.7 4.2.99.-] | (RefSeq) POLB; DNA polymerase beta [KO:K02330] [EC:4.2.99.- 2.7.7.7]
1031  
K06622 cyclin-dependent kinase inhibitor 2C | (RefSeq) CDKN2C; cyclin dependent kinase inhibitor 2C [KO:K06622]
3932  
K05856 lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2] | (RefSeq) LCK; LCK proto-oncogene, Src family tyrosine kinase [KO:K05856] [EC:2.7.10.2]
7015  
K11126 telomerase reverse transcriptase [EC:2.7.7.49] | (RefSeq) TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
4602  
K09420 myb proto-oncogene protein | (RefSeq) MYB; MYB proto-oncogene, transcription factor [KO:K09420]
4603  
K09421 myb-related protein | (RefSeq) MYBL1; MYB proto-oncogene like 1 [KO:K09421]
4605  
K09421 myb-related protein | (RefSeq) MYBL2; MYB proto-oncogene like 2 [KO:K09421]
7046  
K04674 TGF-beta receptor type-1 [EC:2.7.11.30] | (RefSeq) TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
7048  
K04388 TGF-beta receptor type-2 [EC:2.7.11.30] | (RefSeq) TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
4087  
K04500 mothers against decapentaplegic homolog 2/3 | (RefSeq) SMAD2; SMAD family member 2 [KO:K04500]
4088  
K04500 mothers against decapentaplegic homolog 2/3 | (RefSeq) SMAD3; SMAD family member 3 [KO:K04500]
4089  
K04501 mothers against decapentaplegic homolog 4 | (RefSeq) SMAD4; SMAD family member 4 [KO:K04501]
472  
K04728 ataxia telangiectasia mutated family protein [EC:2.7.11.1] | (RefSeq) ATM; ATM serine/threonine kinase [KO:K04728] [EC:2.7.11.1]
545  
K06640 serine/threonine-protein kinase ATR [EC:2.7.11.1] | (RefSeq) ATR; ATR serine/threonine kinase [KO:K06640] [EC:2.7.11.1]
1111  
K02216 serine/threonine-protein kinase Chk1 [EC:2.7.11.1] | (RefSeq) CHEK1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
11200  
K06641 serine/threonine-protein kinase Chk2 [EC:2.7.11.1] | (RefSeq) CHEK2; checkpoint kinase 2 [KO:K06641] [EC:2.7.11.1]
7157  
K04451 tumor protein p53 | (RefSeq) TP53; tumor protein p53 [KO:K04451]
581  
K02159 apoptosis regulator BAX | (RefSeq) BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
94241  
K15310 tumor protein p53-inducible nuclear protein 1 | (RefSeq) TP53INP1; tumor protein p53 inducible nuclear protein 1 [KO:K15310]
4487  
K09341 homeobox protein MSX | (RefSeq) MSX1; msh homeobox 1 [KO:K09341]
4488  
K09341 homeobox protein MSX | (RefSeq) MSX2; msh homeobox 2 [KO:K09341]
5599  
K04440 c-Jun N-terminal kinase [EC:2.7.11.24] | (RefSeq) MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
9133  
K05868 cyclin B | (RefSeq) CCNB2; cyclin B2 [KO:K05868]
Compound
C00027  
Hydrogen peroxide
C00076  
Calcium cation
C00238  
Potassium cation
C00575  
3',5'-Cyclic AMP
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C18994  
Accessory protein p12I
C18995  
P13 protein
C18996  
Accessory protein p30II
C19313  
HTLV-1 basic zipper factor
Reference
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
Reference
  Authors
Gatza ML, Watt JC, Marriott SJ
  Title
Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades.
  Journal
Oncogene 22:5141-9 (2003)
Reference
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
Reference
  Authors
Boxus M, Willems L
  Title
Mechanisms of HTLV-1 persistence and transformation.
  Journal
Br J Cancer 101:1497-501 (2009)
Reference
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
Reference
  Authors
Yasunaga J, Matsuoka M
  Title
[HTLV-I and leukemogenesis].
  Journal
Uirusu 56:241-9 (2006)
Reference
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
Reference
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
  Journal
IUBMB Life 57:83-91 (2005)
Reference
  Authors
Peloponese JM Jr, Jeang KT
  Title
Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoprotein.
  Journal
J Biol Chem 281:8927-38 (2006)
Reference
  Authors
Marriott SJ, Semmes OJ
  Title
Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response.
  Journal
Oncogene 24:5986-95 (2005)
Reference
  Authors
Jeang KT
  Title
Functional activities of the human T-cell leukemia virus type I Tax oncoprotein:  cellular signaling through NF-kappa B.
  Journal
Cytokine Growth Factor Rev 12:207-17 (2001)
Reference
  Authors
Bouzar AB, Willems L
  Title
How HTLV-1 may subvert miRNAs for persistence and transformation.
  Journal
Retrovirology 5:101 (2008)
Reference
  Authors
Sun SC, Yamaoka S
  Title
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
  Journal
Oncogene 24:5952-64 (2005)
Reference
  Authors
Manel N, Battini JL, Taylor N, Sitbon M
  Title
HTLV-1 tropism and envelope receptor.
  Journal
Oncogene 24:6016-25 (2005)
Reference
  Authors
Sun SC, Ballard DW
  Title
Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases.
  Journal
Oncogene 18:6948-58 (1999)
Reference
  Authors
Taylor GP, Matsuoka M
  Title
Natural history of adult T-cell leukemia/lymphoma and approaches to therapy.
  Journal
Oncogene 24:6047-57 (2005)
Reference
  Authors
Franchini G, Fukumoto R, Fullen JR
  Title
T-cell control by human T-cell leukemia/lymphoma virus type 1.
  Journal
Int J Hematol 78:280-96 (2003)
Reference
  Authors
Baydoun HH, Bellon M, Nicot C
  Title
HTLV-1 Yin and Yang: Rex and p30 master regulators of viral mRNA trafficking.
  Journal
AIDS Rev 10:195-204 (2008)
Reference
PMID:9325311
  Authors
Jin DY, Teramoto H, Giam CZ, Chun RF, Gutkind JS, Jeang KT
  Title
A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha.
  Journal
J Biol Chem 272:25816-23 (1997)
Reference
  Authors
Pise-Masison CA, Brady JN
  Title
Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function.
  Journal
Front Biosci 10:919-30 (2005)
KO pathway
 

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