KEGG   PATHWAY: hsa05169Help
Entry
hsa05169                    Pathway                                

Name
Epstein-Barr virus infection - Homo sapiens (human)
Description
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxic T cells, causing infectious mononucleosis during adolescence. Primary infection with EBV is followed by latent infection in which the reservoir B cells are immortalized. EBV tumorigenic potential in Burkitt lymphoma, nasopharyngeal carcinoma, Hodgkin lymphoma, and post-transplant B cell lymphomas has been well-documented. Distinct forms of EBV latency and patterns of latent gene expression can contribute to the different tumours.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
Epstein-Barr virus infection
hsa05169

All organismsOrtholog table
Disease
H00367  
Infectious mononucleosis
Organism
Homo sapiens (human) [GN:hsa]
Gene
1380  
CR2; complement component (3d/Epstein Barr virus) receptor 2 [KO:K04012]
5430  
POLR2A; polymerase (RNA) II (DNA directed) polypeptide A, 220kDa [KO:K03006] [EC:2.7.7.6]
5431  
POLR2B; polymerase (RNA) II (DNA directed) polypeptide B, 140kDa [KO:K03010] [EC:2.7.7.6]
5432  
POLR2C; polymerase (RNA) II (DNA directed) polypeptide C, 33kDa [KO:K03011]
5439  
POLR2J; polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa [KO:K03008]
548644  
POLR2J3; polymerase (RNA) II (DNA directed) polypeptide J3 [KO:K03008]
246721  
POLR2J2; polymerase (RNA) II (DNA directed) polypeptide J2 [KO:K03008]
5433  
POLR2D; polymerase (RNA) II (DNA directed) polypeptide D [KO:K03012]
5436  
POLR2G; polymerase (RNA) II (DNA directed) polypeptide G [KO:K03015]
5438  
POLR2I; polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa [KO:K03017]
5434  
POLR2E; polymerase (RNA) II (DNA directed) polypeptide E, 25kDa [KO:K03013]
5435  
POLR2F; polymerase (RNA) II (DNA directed) polypeptide F [KO:K03014]
5437  
POLR2H; polymerase (RNA) II (DNA directed) polypeptide H [KO:K03016]
5440  
POLR2K; polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa [KO:K03009]
5441  
POLR2L; polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa [KO:K03007]
11128  
POLR3A; polymerase (RNA) III (DNA directed) polypeptide A, 155kDa [KO:K03018] [EC:2.7.7.6]
55703  
POLR3B; polymerase (RNA) III (DNA directed) polypeptide B [KO:K03021] [EC:2.7.7.6]
9533  
POLR1C; polymerase (RNA) I polypeptide C, 30kDa [KO:K03027]
51082  
POLR1D; polymerase (RNA) I polypeptide D, 16kDa [KO:K03020]
10623  
POLR3C; polymerase (RNA) III (DNA directed) polypeptide C (62kD) [KO:K03023]
661  
POLR3D; polymerase (RNA) III (DNA directed) polypeptide D, 44kDa [KO:K03026]
55718  
POLR3E; polymerase (RNA) III (DNA directed) polypeptide E (80kD) [KO:K14721]
DNA-directed RNA polymerase III subunit RPC5-like; K14721 DNA-directed RNA polymerase III subunit RPC5 [KO:K14721]
10621  
POLR3F; polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa [KO:K03025]
84265  
POLR3GL; polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like [KO:K03024]
10622  
POLR3G; polymerase (RNA) III (DNA directed) polypeptide G (32kD) [KO:K03024]
171568  
POLR3H; polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) [KO:K03022]
51728  
POLR3K; polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa [KO:K03019]
7514  
XPO1; exportin 1 [KO:K14290]
5901  
RAN; RAN, member RAS oncogene family [KO:K07936]
8021  
NUP214; nucleoporin 214kDa [KO:K14317]
3105  
HLA-A; major histocompatibility complex, class I, A [KO:K06751]
3106  
HLA-B; major histocompatibility complex, class I, B [KO:K06751]
3107  
HLA-C; major histocompatibility complex, class I, C [KO:K06751]
3134  
HLA-F; major histocompatibility complex, class I, F [KO:K06751]
3135  
HLA-G; major histocompatibility complex, class I, G [KO:K06751]
3133  
HLA-E; major histocompatibility complex, class I, E [KO:K06751]
952  
CD38; CD38 molecule [KO:K01242] [EC:2.4.99.20 3.2.2.6]
6693  
SPN; sialophorin [KO:K06477]
leukosialin-like; K06477 sialophorin [KO:K06477]
983  
CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.23 2.7.11.22]
26993  
AKAP8L; A kinase (PRKA) anchor protein 8-like [KO:K15978]
3312  
HSPA8; heat shock 70kDa protein 8 [KO:K03283]
3303  
HSPA1A; heat shock 70kDa protein 1A [KO:K03283]
3306  
HSPA2; heat shock 70kDa protein 2 [KO:K03283]
3305  
HSPA1L; heat shock 70kDa protein 1-like [KO:K03283]
3304  
HSPA1B; heat shock 70kDa protein 1B [KO:K03283]
3310  
HSPA6; heat shock 70kDa protein 6 (HSP70B') [KO:K03283]
3315  
HSPB1; heat shock 27kDa protein 1 [KO:K04455]
3316  
HSPB2; heat shock 27kDa protein 2 [KO:K09543]
7534  
YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta [KO:K16197]
7529  
YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta [KO:K16197]
10971  
YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta [KO:K16197]
7531  
YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon [KO:K06630]
7533  
YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta [KO:K16198]
7532  
YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma [KO:K16198]
2959  
GTF2B; general transcription factor IIB [KO:K03124]
27044  
SND1; staphylococcal nuclease and tudor domain containing 1 [KO:K15979]
2960  
GTF2E1; general transcription factor IIE, polypeptide 1, alpha 56kDa [KO:K03136]
2961  
GTF2E2; general transcription factor IIE, polypeptide 2, beta 34kDa [KO:K03137]
9759  
HDAC4; histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
10014  
HDAC5; histone deacetylase 5 [KO:K11406] [EC:3.5.1.98]
22938  
SNW1; SNW domain containing 1 [KO:K06063]
9612  
NCOR2; nuclear receptor corepressor 2 [KO:K06065]
11317  
RBPJL; recombination signal binding protein for immunoglobulin kappa J region-like [KO:K06053]
3516  
RBPJ; recombination signal binding protein for immunoglobulin kappa J region [KO:K06053]
6688  
SPI1; spleen focus forming virus (SFFV) proviral integration oncogene [KO:K09438]
3065  
HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
3066  
HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
1387  
CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
2033  
EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
5757  
PTMA; prothymosin, alpha [KO:K13784]
2208  
FCER2; Fc fragment of IgE, low affinity II, receptor for (CD23) [KO:K06468]
2268  
FGR; feline Gardner-Rasheed sarcoma viral oncogene homolog [KO:K08891] [EC:2.7.10.2]
4609  
MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
7157  
TP53; tumor protein p53 [KO:K04451]
387332  
TBPL2; TATA box binding protein like 2 [KO:K03120]
9519  
TBPL1; TBP-like 1 [KO:K03120]
6908  
TBP; TATA box binding protein [KO:K03120]
1026  
CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) [KO:K06625]
4193  
MDM2; MDM2 oncogene, E3 ubiquitin protein ligase [KO:K06643] [EC:6.3.2.19]
5701  
PSMC2; proteasome (prosome, macropain) 26S subunit, ATPase, 2 [KO:K03061]
5700  
PSMC1; proteasome (prosome, macropain) 26S subunit, ATPase, 1 [KO:K03062]
5704  
PSMC4; proteasome (prosome, macropain) 26S subunit, ATPase, 4 [KO:K03063]
5706  
PSMC6; proteasome (prosome, macropain) 26S subunit, ATPase, 6 [KO:K03064]
5702  
PSMC3; proteasome (prosome, macropain) 26S subunit, ATPase, 3 [KO:K03065]
5705  
PSMC5; proteasome (prosome, macropain) 26S subunit, ATPase, 5 [KO:K03066]
5708  
PSMD2; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 [KO:K03028]
5707  
PSMD1; proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 [KO:K03032]
5709  
PSMD3; proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 [KO:K03033]
5718  
PSMD12; proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 [KO:K03035]
5717  
PSMD11; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 [KO:K03036]
9861  
PSMD6; proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [KO:K03037]
5713  
PSMD7; proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 [KO:K03038]
5719  
PSMD13; proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 [KO:K03039]
5710  
PSMD4; proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 [KO:K03029]
10213  
PSMD14; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 [KO:K03030]
5714  
PSMD8; proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 [KO:K03031]
7979  
SHFM1; split hand/foot malformation (ectrodactyly) type 1 [KO:K10881]
7874  
USP7; ubiquitin specific peptidase 7 (herpes virus-associated) [KO:K11838] [EC:3.1.2.15]
5566  
PRKACA; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
5567  
PRKACB; protein kinase, cAMP-dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
5568  
PRKACG; protein kinase, cAMP-dependent, catalytic, gamma [KO:K04345] [EC:2.7.11.11]
5613  
PRKX; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
1457  
CSNK2A1; casein kinase 2, alpha 1 polypeptide [KO:K03097] [EC:2.7.11.1]
1459  
CSNK2A2; casein kinase 2, alpha prime polypeptide [KO:K03097] [EC:2.7.11.1]
1460  
CSNK2B; casein kinase 2, beta polypeptide [KO:K03115]
1027  
CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1) [KO:K06624]
890  
CCNA2; cyclin A2 [KO:K06627]
8900  
CCNA1; cyclin A1 [KO:K06627]
1017  
CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
5925  
RB1; retinoblastoma 1 [KO:K06618]
6502  
SKP2; S-phase kinase-associated protein 2, E3 ubiquitin protein ligase [KO:K03875]
5290  
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294  
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
5295  
PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
23533  
PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
5296  
PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
8503  
PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO:K02649]
207  
AKT1; v-akt murine thymoma viral oncogene homolog 1 [KO:K04456] [EC:2.7.11.1]
208  
AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
10000  
AKT3; v-akt murine thymoma viral oncogene homolog 3 [KO:K04456] [EC:2.7.11.1]
2932  
GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
7185  
TRAF1; TNF receptor-associated factor 1 [KO:K03172]
7186  
TRAF2; TNF receptor-associated factor 2 [KO:K03173]
7187  
TRAF3; TNF receptor-associated factor 3 [KO:K03174]
7188  
TRAF5; TNF receptor-associated factor 5 [KO:K09849]
9020  
MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
1147  
CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
5971  
RELB; v-rel avian reticuloendotheliosis viral oncogene homolog B [KO:K09253]
4791  
NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) [KO:K04469]
8717  
TRADD; TNFRSF1A-associated via death domain [KO:K03171]
8737  
RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
8517  
IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [KO:K07210]
3551  
IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
4793  
NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta [KO:K02581]
4792  
NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [KO:K04734]
4794  
NFKBIE; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon [KO:K05872]
4790  
NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
5970  
RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A [KO:K04735]
3654  
IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
7189  
TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase [KO:K03175]
10454  
TAB1; TGF-beta activated kinase 1/MAP3K7 binding protein 1 [KO:K04403]
23118  
TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
6885  
MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
5606  
MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
5608  
MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
5600  
MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
6300  
MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
5603  
MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
1432  
MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
6416  
MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
5609  
MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
5599  
MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
5602  
MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
5601  
MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
3725  
JUN; jun proto-oncogene [KO:K04448]
1386  
ATF2; activating transcription factor 2 [KO:K04450]
3718  
JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
956  
ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
377841  
ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
953  
ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
958  
CD40; CD40 molecule, TNF receptor superfamily member 5 [KO:K03160]
960  
CD44; CD44 molecule (Indian blood group) [KO:K06256]
3683  
ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1 [KO:K05718]
965  
CD58; CD58 molecule [KO:K06492]
3383  
ICAM1; intercellular adhesion molecule 1 [KO:K06490]
7431  
VIM; vimentin [KO:K07606]
7128  
TNFAIP3; tumor necrosis factor, alpha-induced protein 3 [KO:K11859] [EC:6.3.2.19 3.4.19.12]
596  
BCL2; B-cell CLL/lymphoma 2 [KO:K02161]
4067  
LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog [KO:K05854] [EC:2.7.10.2]
6850  
SYK; spleen tyrosine kinase [KO:K05855] [EC:2.7.10.2]
5335  
PLCG1; phospholipase C, gamma 1 [KO:K01116] [EC:3.1.4.11]
5336  
PLCG2; phospholipase C, gamma 2 (phosphatidylinositol-specific) [KO:K05859] [EC:3.1.4.11]
930  
CD19; CD19 molecule [KO:K06465]
4734  
NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase [KO:K10591] [EC:6.3.2.19]
23586  
DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 [KO:K12646] [EC:3.6.3.14]
3458  
IFNG; interferon, gamma [KO:K04687]
29110  
TBK1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
3661  
IRF3; interferon regulatory factor 3 [KO:K05411]
3586  
IL10; interleukin 10 [KO:K05443]
27102  
EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
5610  
EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
9451  
EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
440275  
EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
3587  
IL10RA; interleukin 10 receptor, alpha [KO:K05134]
3588  
IL10RB; interleukin 10 receptor, beta [KO:K05135]
3716  
JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
7297  
TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
6774  
STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) [KO:K04692]
3113  
HLA-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
3115  
HLA-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
3117  
HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
3118  
HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
3119  
HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
3122  
HLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
3123  
HLA-DRB1; major histocompatibility complex, class II, DR beta 1 [KO:K06752]
3125  
HLA-DRB3; major histocompatibility complex, class II, DR beta 3 [KO:K06752]
3126  
HLA-DRB4; major histocompatibility complex, class II, DR beta 4 [KO:K06752]
3127  
HLA-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
Compound
C00076  
Calcium cation
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Kieff E, Rickinson AB.
  Title
Epstein-Barr virus and its replication.
  Journal
Fields Virology. New York, Lippincott-Raven
Reference
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
Reference
  Authors
Young LS, Murray PG
  Title
Epstein-Barr virus and oncogenesis: from latent genes to tumours.
  Journal
Oncogene 22:5108-21 (2003)
Reference
  Authors
Haan KM, Kwok WW, Longnecker R, Speck P
  Title
Epstein-Barr virus entry utilizing HLA-DP or HLA-DQ as a coreceptor.
  Journal
J Virol 74:2451-4 (2000)
Reference
  Authors
Knight JS, Sharma N, Robertson ES
  Title
Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase.
  Journal
Proc Natl Acad Sci U S A 102:18562-6 (2005)
Reference
  Authors
Knight JS, Sharma N, Kalman DE, Robertson ES
  Title
A cyclin-binding motif within the amino-terminal homology domain of EBNA3C binds  cyclin A and modulates cyclin A-dependent kinase activity in Epstein-Barr virus-infected cells.
  Journal
J Virol 78:12857-67 (2004)
Reference
  Authors
Cotter MA 2nd, Robertson ES
  Title
Modulation of histone acetyltransferase activity through interaction of epstein-barr nuclear antigen 3C with prothymosin alpha.
  Journal
Mol Cell Biol 20:5722-35 (2000)
Reference
  Authors
Eliopoulos AG, Caamano JH, Flavell J, Reynolds GM, Murray PG, Poyet JL, Young LS
  Title
Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-kappaB2 to p52 via an IKKgamma/NEMO-independent signalling  pathway.
  Journal
Oncogene 22:7557-69 (2003)
Reference
  Authors
Ikeda M, Ikeda A, Longan LC, Longnecker R
  Title
The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases.
  Journal
Virology 268:178-91 (2000)
Reference
  Authors
Masucci MG
  Title
Epstein-Barr virus oncogenesis and the ubiquitin-proteasome system.
  Journal
Oncogene 23:2107-15 (2004)
Reference
  Authors
Luftig M, Prinarakis E, Yasui T, Tsichritzis T, Cahir-McFarland E, Inoue J, Nakano H, Mak TW, Yeh WC, Li X, Akira S, Suzuki N, Suzuki S, Mosialos G, Kieff E
  Title
Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6.
  Journal
Proc Natl Acad Sci U S A 100:15595-600 (2003)
Reference
  Authors
Mainou BA, Everly DN Jr, Raab-Traub N
  Title
Epstein-Barr virus latent membrane protein 1 CTAR1 mediates rodent and human fibroblast transformation through activation of PI3K.
  Journal
Oncogene 24:6917-24 (2005)
Reference
  Authors
Young KA, Herbert AP, Barlow PN, Holers VM, Hannan JP
  Title
Molecular basis of the interaction between complement receptor type 2 (CR2/CD21)  and Epstein-Barr virus glycoprotein gp350.
  Journal
J Virol 82:11217-27 (2008)
Reference
  Authors
Portal D, Rosendorff A, Kieff E
  Title
Epstein-Barr nuclear antigen leader protein coactivates transcription through interaction with histone deacetylase 4.
  Journal
Proc Natl Acad Sci U S A 103:19278-83 (2006)
Reference
  Authors
Portal D, Zhao B, Calderwood MA, Sommermann T, Johannsen E, Kieff E
  Title
EBV nuclear antigen EBNALP dismisses transcription repressors NCoR and RBPJ from  enhancers and EBNA2 increases NCoR-deficient RBPJ DNA binding.
  Journal
Proc Natl Acad Sci U S A 108:7808-13 (2011)
Reference
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Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD
  Title
A role for SKIP in EBNA2 activation of CBF1-repressed promoters.
  Journal
J Virol 74:1939-47 (2000)
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Brinkmann MM, Schulz TF
  Title
Regulation of intracellular signalling by the terminal membrane proteins of members of the Gammaherpesvirinae.
  Journal
J Gen Virol 87:1047-74 (2006)
Reference
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Anderson LJ, Longnecker R
  Title
EBV LMP2A provides a surrogate pre-B cell receptor signal through constitutive activation of the ERK/MAPK pathway.
  Journal
J Gen Virol 89:1563-8 (2008)
Reference
PMID:1658397
  Authors
Flemington EK, Goldfeld AE, Speck SH
  Title
Efficient transcription of the Epstein-Barr virus immediate-early BZLF1 and BRLF1 genes requires protein synthesis.
  Journal
J Virol 65:7073-7 (1991)
Reference
  Authors
Mauser A, Saito S, Appella E, Anderson CW, Seaman WT, Kenney S
  Title
The Epstein-Barr virus immediate-early protein BZLF1 regulates p53 function through multiple mechanisms.
  Journal
J Virol 76:12503-12 (2002)
Reference
  Authors
Sato Y, Shirata N, Kudoh A, Iwahori S, Nakayama S, Murata T, Isomura H, Nishiyama Y, Tsurumi T
  Title
Expression of Epstein-Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2, leading to repression of p53-mediated transcription.
  Journal
Virology 388:204-11 (2009)
Reference
PMID:7895172
  Authors
Miller CL, Burkhardt AL, Lee JH, Stealey B, Longnecker R, Bolen JB, Kieff E
  Title
Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases.
  Journal
Immunity 2:155-66 (1995)
Reference
  Authors
Boyle SM, Ruvolo V, Gupta AK, Swaminathan S
  Title
Association with the cellular export receptor CRM 1 mediates function and intracellular localization of Epstein-Barr virus SM protein, a regulator of gene  expression.
  Journal
J Virol 73:6872-81 (1999)
Reference
PMID:9565632
  Authors
Callan MF, Tan L, Annels N, Ogg GS, Wilson JD, O'Callaghan CA, Steven N, McMichael AJ, Rickinson AB
  Title
Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo.
  Journal
J Exp Med 187:1395-402 (1998)
Reference
  Authors
Isobe Y.
  Title
EB virus and oncogenesis. [Japanese]
  Journal
Genomu Igaku. Tokyo, Medical Review Co. Ltd.
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