KEGG   Homo sapiens (human): 10000Help
Entry
10000             CDS       T01001                                 

Gene name
AKT3, MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2
Definition
(RefSeq) AKT serine/threonine kinase 3
  KO
K04456  
RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Platinum drug resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Longevity regulating pathway
Longevity regulating pathway - multiple species
Cellular senescence
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Apelin signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Neurotrophin signaling pathway
Cholinergic synapse
Dopaminergic synapse
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Glucagon signaling pathway
Regulation of lipolysis in adipocytes
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
AGE-RAGE signaling pathway in diabetic complications
Carbohydrate digestion and absorption
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Measles
Influenza A
Human papillomavirus infection
HTLV-I infection
Kaposi's sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Fluid shear stress and atherosclerosis
Module
PI3K-Akt signaling
Drug target
Afuresertib (DG01408): 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    10000 (AKT3)
   04015 Rap1 signaling pathway
    10000 (AKT3)
   04010 MAPK signaling pathway
    10000 (AKT3)
   04012 ErbB signaling pathway
    10000 (AKT3)
   04370 VEGF signaling pathway
    10000 (AKT3)
   04371 Apelin signaling pathway
    10000 (AKT3)
   04630 Jak-STAT signaling pathway
    10000 (AKT3)
   04668 TNF signaling pathway
    10000 (AKT3)
   04066 HIF-1 signaling pathway
    10000 (AKT3)
   04068 FoxO signaling pathway
    10000 (AKT3)
   04072 Phospholipase D signaling pathway
    10000 (AKT3)
   04071 Sphingolipid signaling pathway
    10000 (AKT3)
   04024 cAMP signaling pathway
    10000 (AKT3)
   04022 cGMP - PKG signaling pathway
    10000 (AKT3)
   04151 PI3K-Akt signaling pathway
    10000 (AKT3)
   04152 AMPK signaling pathway
    10000 (AKT3)
   04150 mTOR signaling pathway
    10000 (AKT3)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    10000 (AKT3)
  Cell growth and death
   04210 Apoptosis
    10000 (AKT3)
   04218 Cellular senescence
    10000 (AKT3)
  Cellular community - eukaryotes
   04510 Focal adhesion
    10000 (AKT3)
   04550 Signaling pathways regulating pluripotency of stem cells
    10000 (AKT3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    10000 (AKT3)
   04620 Toll-like receptor signaling pathway
    10000 (AKT3)
   04660 T cell receptor signaling pathway
    10000 (AKT3)
   04662 B cell receptor signaling pathway
    10000 (AKT3)
   04664 Fc epsilon RI signaling pathway
    10000 (AKT3)
   04666 Fc gamma R-mediated phagocytosis
    10000 (AKT3)
   04062 Chemokine signaling pathway
    10000 (AKT3)
  Endocrine system
   04910 Insulin signaling pathway
    10000 (AKT3)
   04922 Glucagon signaling pathway
    10000 (AKT3)
   04923 Regulation of lipolysis in adipocyte
    10000 (AKT3)
   04920 Adipocytokine signaling pathway
    10000 (AKT3)
   04915 Estrogen signaling pathway
    10000 (AKT3)
   04914 Progesterone-mediated oocyte maturation
    10000 (AKT3)
   04917 Prolactin signaling pathway
    10000 (AKT3)
   04919 Thyroid hormone signaling pathway
    10000 (AKT3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    10000 (AKT3)
  Digestive system
   04973 Carbohydrate digestion and absorption
    10000 (AKT3)
  Nervous system
   04725 Cholinergic synapse
    10000 (AKT3)
   04728 Dopaminergic synapse
    10000 (AKT3)
   04722 Neurotrophin signaling pathway
    10000 (AKT3)
  Development
   04380 Osteoclast differentiation
    10000 (AKT3)
  Aging
   04211 Longevity regulating pathway - mammal
    10000 (AKT3)
   04213 Longevity regulating pathway - multiple species
    10000 (AKT3)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    10000 (AKT3)
   05230 Central carbon metabolism in cancer
    10000 (AKT3)
   05231 Choline metabolism in cancer
    10000 (AKT3)
   05205 Proteoglycans in cancer
    10000 (AKT3)
   05210 Colorectal cancer
    10000 (AKT3)
   05212 Pancreatic cancer
    10000 (AKT3)
   05214 Glioma
    10000 (AKT3)
   05221 Acute myeloid leukemia
    10000 (AKT3)
   05220 Chronic myeloid leukemia
    10000 (AKT3)
   05218 Melanoma
    10000 (AKT3)
   05211 Renal cell carcinoma
    10000 (AKT3)
   05215 Prostate cancer
    10000 (AKT3)
   05213 Endometrial cancer
    10000 (AKT3)
   05224 Breast cancer
    10000 (AKT3)
   05222 Small cell lung cancer
    10000 (AKT3)
   05223 Non-small cell lung cancer
    10000 (AKT3)
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    10000 (AKT3)
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    10000 (AKT3)
   04931 Insulin resistance
    10000 (AKT3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    10000 (AKT3)
  Infectious diseases
   05152 Tuberculosis
    10000 (AKT3)
   05166 HTLV-I infection
    10000 (AKT3)
   05162 Measles
    10000 (AKT3)
   05164 Influenza A
    10000 (AKT3)
   05161 Hepatitis B
    10000 (AKT3)
   05160 Hepatitis C
    10000 (AKT3)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    10000 (AKT3)
   05169 Epstein-Barr virus infection
    10000 (AKT3)
   05165 Human papillomavirus infection
    10000 (AKT3)
   05145 Toxoplasmosis
    10000 (AKT3)
   05142 Chagas disease (American trypanosomiasis)
    10000 (AKT3)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    10000 (AKT3)
   01524 Platinum drug resistance
    10000 (AKT3)
   01522 Endocrine resistance
    10000 (AKT3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     10000 (AKT3)
Protein kinases [BR:hsa01001]
 Serine/threonine protein kinases: AGC group
  AKT/PKB family
   10000 (AKT3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
Q9Y243(Tchem)
UniProt: 
Structure
PDB: 

Jmol
Position
1q43-q44
AA seq 479 aa AA seqDB search
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
NT seq 1440 nt NT seq  +upstreamnt  +downstreamnt
atgagcgatgttaccattgtgaaagaaggttgggttcagaagaggggagaatatataaaa
aactggaggccaagatacttccttttgaagacagatggctcattcataggatataaagag
aaacctcaagatgtggatttaccttatcccctcaacaacttttcagtggcaaaatgccag
ttaatgaaaacagaacgaccaaagccaaacacatttataatcagatgtctccagtggact
actgttatagagagaacatttcatgtagatactccagaggaaagggaagaatggacagaa
gctatccaggctgtagcagacagactgcagaggcaagaagaggagagaatgaattgtagt
ccaacttcacaaattgataatataggagaggaagagatggatgcctctacaacccatcat
aaaagaaagacaatgaatgattttgactatttgaaactactaggtaaaggcacttttggg
aaagttattttggttcgagagaaggcaagtggaaaatactatgctatgaagattctgaag
aaagaagtcattattgcaaaggatgaagtggcacacactctaactgaaagcagagtatta
aagaacactagacatccctttttaacatccttgaaatattccttccagacaaaagaccgt
ttgtgttttgtgatggaatatgttaatgggggcgagctgtttttccatttgtcgagagag
cgggtgttctctgaggaccgcacacgtttctatggtgcagaaattgtctctgccttggac
tatctacattccggaaagattgtgtaccgtgatctcaagttggagaatctaatgctggac
aaagatggccacataaaaattacagattttggactttgcaaagaagggatcacagatgca
gccaccatgaagacattctgtggcactccagaatatctggcaccagaggtgttagaagat
aatgactatggccgagcagtagactggtggggcctaggggttgtcatgtatgaaatgatg
tgtgggaggttacctttctacaaccaggaccatgagaaactttttgaattaatattaatg
gaagacattaaatttcctcgaacactctcttcagatgcaaaatcattgctttcagggctc
ttgataaaggatccaaataaacgccttggtggaggaccagatgatgcaaaagaaattatg
agacacagtttcttctctggagtaaactggcaagatgtatatgataaaaagcttgtacct
ccttttaaacctcaagtaacatctgagacagatactagatattttgatgaagaatttaca
gctcagactattacaataacaccacctgaaaaatatgatgaggatggtatggactgcatg
gacaatgagaggcggccgcatttccctcaattttcctactctgcaagtggacgagaataa

KEGG   Homo sapiens (human): 207Help
Entry
207               CDS       T01001                                 

Gene name
AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
Definition
(RefSeq) AKT serine/threonine kinase 1
  KO
K04456  
RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Platinum drug resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Longevity regulating pathway
Longevity regulating pathway - multiple species
Cellular senescence
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Apelin signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Neurotrophin signaling pathway
Cholinergic synapse
Dopaminergic synapse
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Glucagon signaling pathway
Regulation of lipolysis in adipocytes
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
AGE-RAGE signaling pathway in diabetic complications
Carbohydrate digestion and absorption
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Measles
Influenza A
Human papillomavirus infection
HTLV-I infection
Kaposi's sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Fluid shear stress and atherosclerosis
Module
PI3K-Akt signaling
Disease
H00539  
PTEN hamartoma tumor syndrome (PHTS)
H01556  
Meningioma
H01649  
Schizophrenia
Drug target
Afuresertib (DG01408): 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    207 (AKT1)
   04015 Rap1 signaling pathway
    207 (AKT1)
   04010 MAPK signaling pathway
    207 (AKT1)
   04012 ErbB signaling pathway
    207 (AKT1)
   04370 VEGF signaling pathway
    207 (AKT1)
   04371 Apelin signaling pathway
    207 (AKT1)
   04630 Jak-STAT signaling pathway
    207 (AKT1)
   04668 TNF signaling pathway
    207 (AKT1)
   04066 HIF-1 signaling pathway
    207 (AKT1)
   04068 FoxO signaling pathway
    207 (AKT1)
   04072 Phospholipase D signaling pathway
    207 (AKT1)
   04071 Sphingolipid signaling pathway
    207 (AKT1)
   04024 cAMP signaling pathway
    207 (AKT1)
   04022 cGMP - PKG signaling pathway
    207 (AKT1)
   04151 PI3K-Akt signaling pathway
    207 (AKT1)
   04152 AMPK signaling pathway
    207 (AKT1)
   04150 mTOR signaling pathway
    207 (AKT1)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    207 (AKT1)
  Cell growth and death
   04210 Apoptosis
    207 (AKT1)
   04218 Cellular senescence
    207 (AKT1)
  Cellular community - eukaryotes
   04510 Focal adhesion
    207 (AKT1)
   04550 Signaling pathways regulating pluripotency of stem cells
    207 (AKT1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    207 (AKT1)
   04620 Toll-like receptor signaling pathway
    207 (AKT1)
   04660 T cell receptor signaling pathway
    207 (AKT1)
   04662 B cell receptor signaling pathway
    207 (AKT1)
   04664 Fc epsilon RI signaling pathway
    207 (AKT1)
   04666 Fc gamma R-mediated phagocytosis
    207 (AKT1)
   04062 Chemokine signaling pathway
    207 (AKT1)
  Endocrine system
   04910 Insulin signaling pathway
    207 (AKT1)
   04922 Glucagon signaling pathway
    207 (AKT1)
   04923 Regulation of lipolysis in adipocyte
    207 (AKT1)
   04920 Adipocytokine signaling pathway
    207 (AKT1)
   04915 Estrogen signaling pathway
    207 (AKT1)
   04914 Progesterone-mediated oocyte maturation
    207 (AKT1)
   04917 Prolactin signaling pathway
    207 (AKT1)
   04919 Thyroid hormone signaling pathway
    207 (AKT1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    207 (AKT1)
  Digestive system
   04973 Carbohydrate digestion and absorption
    207 (AKT1)
  Nervous system
   04725 Cholinergic synapse
    207 (AKT1)
   04728 Dopaminergic synapse
    207 (AKT1)
   04722 Neurotrophin signaling pathway
    207 (AKT1)
  Development
   04380 Osteoclast differentiation
    207 (AKT1)
  Aging
   04211 Longevity regulating pathway - mammal
    207 (AKT1)
   04213 Longevity regulating pathway - multiple species
    207 (AKT1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    207 (AKT1)
   05230 Central carbon metabolism in cancer
    207 (AKT1)
   05231 Choline metabolism in cancer
    207 (AKT1)
   05205 Proteoglycans in cancer
    207 (AKT1)
   05210 Colorectal cancer
    207 (AKT1)
   05212 Pancreatic cancer
    207 (AKT1)
   05214 Glioma
    207 (AKT1)
   05221 Acute myeloid leukemia
    207 (AKT1)
   05220 Chronic myeloid leukemia
    207 (AKT1)
   05218 Melanoma
    207 (AKT1)
   05211 Renal cell carcinoma
    207 (AKT1)
   05215 Prostate cancer
    207 (AKT1)
   05213 Endometrial cancer
    207 (AKT1)
   05224 Breast cancer
    207 (AKT1)
   05222 Small cell lung cancer
    207 (AKT1)
   05223 Non-small cell lung cancer
    207 (AKT1)
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    207 (AKT1)
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    207 (AKT1)
   04931 Insulin resistance
    207 (AKT1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    207 (AKT1)
  Infectious diseases
   05152 Tuberculosis
    207 (AKT1)
   05166 HTLV-I infection
    207 (AKT1)
   05162 Measles
    207 (AKT1)
   05164 Influenza A
    207 (AKT1)
   05161 Hepatitis B
    207 (AKT1)
   05160 Hepatitis C
    207 (AKT1)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    207 (AKT1)
   05169 Epstein-Barr virus infection
    207 (AKT1)
   05165 Human papillomavirus infection
    207 (AKT1)
   05145 Toxoplasmosis
    207 (AKT1)
   05142 Chagas disease (American trypanosomiasis)
    207 (AKT1)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    207 (AKT1)
   01524 Platinum drug resistance
    207 (AKT1)
   01522 Endocrine resistance
    207 (AKT1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     207 (AKT1)
Protein kinases [BR:hsa01001]
 Serine/threonine protein kinases: AGC group
  AKT/PKB family
   207 (AKT1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
P31749(Tchem)
UniProt: 
Structure
PDB: 

Jmol
Position
14q32.33
AA seq 480 aa AA seqDB search
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
NT seq 1443 nt NT seq  +upstreamnt  +downstreamnt
atgagcgacgtggctattgtgaaggagggttggctgcacaaacgaggggagtacatcaag
acctggcggccacgctacttcctcctcaagaatgatggcaccttcattggctacaaggag
cggccgcaggatgtggaccaacgtgaggctcccctcaacaacttctctgtggcgcagtgc
cagctgatgaagacggagcggccccggcccaacaccttcatcatccgctgcctgcagtgg
accactgtcatcgaacgcaccttccatgtggagactcctgaggagcgggaggagtggaca
accgccatccagactgtggctgacggcctcaagaagcaggaggaggaggagatggacttc
cggtcgggctcacccagtgacaactcaggggctgaagagatggaggtgtccctggccaag
cccaagcaccgcgtgaccatgaacgagtttgagtacctgaagctgctgggcaagggcact
ttcggcaaggtgatcctggtgaaggagaaggccacaggccgctactacgccatgaagatc
ctcaagaaggaagtcatcgtggccaaggacgaggtggcccacacactcaccgagaaccgc
gtcctgcagaactccaggcaccccttcctcacagccctgaagtactctttccagacccac
gaccgcctctgctttgtcatggagtacgccaacgggggcgagctgttcttccacctgtcc
cgggagcgtgtgttctccgaggaccgggcccgcttctatggcgctgagattgtgtcagcc
ctggactacctgcactcggagaagaacgtggtgtaccgggacctcaagctggagaacctc
atgctggacaaggacgggcacattaagatcacagacttcgggctgtgcaaggaggggatc
aaggacggtgccaccatgaagaccttttgcggcacacctgagtacctggcccccgaggtg
ctggaggacaatgactacggccgtgcagtggactggtgggggctgggcgtggtcatgtac
gagatgatgtgcggtcgcctgcccttctacaaccaggaccatgagaagctttttgagctc
atcctcatggaggagatccgcttcccgcgcacgcttggtcccgaggccaagtccttgctt
tcagggctgctcaagaaggaccccaagcagaggcttggcgggggctccgaggacgccaag
gagatcatgcagcatcgcttctttgccggtatcgtgtggcagcacgtgtacgagaagaag
ctcagcccacccttcaagccccaggtcacgtcggagactgacaccaggtattttgatgag
gagttcacggcccagatgatcaccatcacaccacctgaccaagatgacagcatggagtgt
gtggacagcgagcgcaggccccacttcccccagttctcctactcggccagcggcacggcc
tga

KEGG   Homo sapiens (human): 208Help
Entry
208               CDS       T01001                                 

Gene name
AKT2, HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA
Definition
(RefSeq) AKT serine/threonine kinase 2
  KO
K04456  
RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Platinum drug resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Longevity regulating pathway
Longevity regulating pathway - multiple species
Cellular senescence
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Apelin signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Neurotrophin signaling pathway
Cholinergic synapse
Dopaminergic synapse
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Glucagon signaling pathway
Regulation of lipolysis in adipocytes
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
AGE-RAGE signaling pathway in diabetic complications
Carbohydrate digestion and absorption
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Measles
Influenza A
Human papillomavirus infection
HTLV-I infection
Kaposi's sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Fluid shear stress and atherosclerosis
Module
PI3K-Akt signaling
Disease
H00027  
Ovarian cancer
H00420  
Familial partial lipodystrophy (FPL)
Drug target
Afuresertib (DG01408): 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    208 (AKT2)
   04015 Rap1 signaling pathway
    208 (AKT2)
   04010 MAPK signaling pathway
    208 (AKT2)
   04012 ErbB signaling pathway
    208 (AKT2)
   04370 VEGF signaling pathway
    208 (AKT2)
   04371 Apelin signaling pathway
    208 (AKT2)
   04630 Jak-STAT signaling pathway
    208 (AKT2)
   04668 TNF signaling pathway
    208 (AKT2)
   04066 HIF-1 signaling pathway
    208 (AKT2)
   04068 FoxO signaling pathway
    208 (AKT2)
   04072 Phospholipase D signaling pathway
    208 (AKT2)
   04071 Sphingolipid signaling pathway
    208 (AKT2)
   04024 cAMP signaling pathway
    208 (AKT2)
   04022 cGMP - PKG signaling pathway
    208 (AKT2)
   04151 PI3K-Akt signaling pathway
    208 (AKT2)
   04152 AMPK signaling pathway
    208 (AKT2)
   04150 mTOR signaling pathway
    208 (AKT2)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    208 (AKT2)
  Cell growth and death
   04210 Apoptosis
    208 (AKT2)
   04218 Cellular senescence
    208 (AKT2)
  Cellular community - eukaryotes
   04510 Focal adhesion
    208 (AKT2)
   04550 Signaling pathways regulating pluripotency of stem cells
    208 (AKT2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    208 (AKT2)
   04620 Toll-like receptor signaling pathway
    208 (AKT2)
   04660 T cell receptor signaling pathway
    208 (AKT2)
   04662 B cell receptor signaling pathway
    208 (AKT2)
   04664 Fc epsilon RI signaling pathway
    208 (AKT2)
   04666 Fc gamma R-mediated phagocytosis
    208 (AKT2)
   04062 Chemokine signaling pathway
    208 (AKT2)
  Endocrine system
   04910 Insulin signaling pathway
    208 (AKT2)
   04922 Glucagon signaling pathway
    208 (AKT2)
   04923 Regulation of lipolysis in adipocyte
    208 (AKT2)
   04920 Adipocytokine signaling pathway
    208 (AKT2)
   04915 Estrogen signaling pathway
    208 (AKT2)
   04914 Progesterone-mediated oocyte maturation
    208 (AKT2)
   04917 Prolactin signaling pathway
    208 (AKT2)
   04919 Thyroid hormone signaling pathway
    208 (AKT2)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    208 (AKT2)
  Digestive system
   04973 Carbohydrate digestion and absorption
    208 (AKT2)
  Nervous system
   04725 Cholinergic synapse
    208 (AKT2)
   04728 Dopaminergic synapse
    208 (AKT2)
   04722 Neurotrophin signaling pathway
    208 (AKT2)
  Development
   04380 Osteoclast differentiation
    208 (AKT2)
  Aging
   04211 Longevity regulating pathway - mammal
    208 (AKT2)
   04213 Longevity regulating pathway - multiple species
    208 (AKT2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    208 (AKT2)
   05230 Central carbon metabolism in cancer
    208 (AKT2)
   05231 Choline metabolism in cancer
    208 (AKT2)
   05205 Proteoglycans in cancer
    208 (AKT2)
   05210 Colorectal cancer
    208 (AKT2)
   05212 Pancreatic cancer
    208 (AKT2)
   05214 Glioma
    208 (AKT2)
   05221 Acute myeloid leukemia
    208 (AKT2)
   05220 Chronic myeloid leukemia
    208 (AKT2)
   05218 Melanoma
    208 (AKT2)
   05211 Renal cell carcinoma
    208 (AKT2)
   05215 Prostate cancer
    208 (AKT2)
   05213 Endometrial cancer
    208 (AKT2)
   05224 Breast cancer
    208 (AKT2)
   05222 Small cell lung cancer
    208 (AKT2)
   05223 Non-small cell lung cancer
    208 (AKT2)
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    208 (AKT2)
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    208 (AKT2)
   04931 Insulin resistance
    208 (AKT2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    208 (AKT2)
  Infectious diseases
   05152 Tuberculosis
    208 (AKT2)
   05166 HTLV-I infection
    208 (AKT2)
   05162 Measles
    208 (AKT2)
   05164 Influenza A
    208 (AKT2)
   05161 Hepatitis B
    208 (AKT2)
   05160 Hepatitis C
    208 (AKT2)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    208 (AKT2)
   05169 Epstein-Barr virus infection
    208 (AKT2)
   05165 Human papillomavirus infection
    208 (AKT2)
   05145 Toxoplasmosis
    208 (AKT2)
   05142 Chagas disease (American trypanosomiasis)
    208 (AKT2)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    208 (AKT2)
   01524 Platinum drug resistance
    208 (AKT2)
   01522 Endocrine resistance
    208 (AKT2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     208 (AKT2)
Protein kinases [BR:hsa01001]
 Serine/threonine protein kinases: AGC group
  AKT/PKB family
   208 (AKT2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
P31751(Tchem)
UniProt: 
Structure
PDB: 

Jmol
Position
19q13.2
AA seq 481 aa AA seqDB search
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
NT seq 1446 nt NT seq  +upstreamnt  +downstreamnt
atgaatgaggtgtctgtcatcaaagaaggctggctccacaagcgtggtgaatacatcaag
acctggaggccacggtacttcctgctgaagagcgacggctccttcattgggtacaaggag
aggcccgaggcccctgatcagactctaccccccttaaacaacttctccgtagcagaatgc
cagctgatgaagaccgagaggccgcgacccaacacctttgtcatacgctgcctgcagtgg
accacagtcatcgagaggaccttccacgtggattctccagacgagagggaggagtggatg
cgggccatccagatggtcgccaacagcctcaagcagcgggccccaggcgaggaccccatg
gactacaagtgtggctcccccagtgactcctccacgactgaggagatggaagtggcggtc
agcaaggcacgggctaaagtgaccatgaatgacttcgactatctcaaactccttggcaag
ggaacctttggcaaagtcatcctggtgcgggagaaggccactggccgctactacgccatg
aagatcctgcggaaggaagtcatcattgccaaggatgaagtcgctcacacagtcaccgag
agccgggtcctccagaacaccaggcacccgttcctcactgcgctgaagtatgccttccag
acccacgaccgcctgtgctttgtgatggagtatgccaacgggggtgagctgttcttccac
ctgtcccgggagcgtgtcttcacagaggagcgggcccggttttatggtgcagagattgtc
tcggctcttgagtacttgcactcgcgggacgtggtataccgcgacatcaagctggaaaac
ctcatgctggacaaagatggccacatcaagatcactgactttggcctctgcaaagagggc
atcagtgacggggccaccatgaaaaccttctgtgggaccccggagtacctggcgcctgag
gtgctggaggacaatgactatggccgggccgtggactggtgggggctgggtgtggtcatg
tacgagatgatgtgcggccgcctgcccttctacaaccaggaccacgagcgcctcttcgag
ctcatcctcatggaagagatccgcttcccgcgcacgctcagccccgaggccaagtccctg
cttgctgggctgcttaagaaggaccccaagcagaggcttggtggggggcccagcgatgcc
aaggaggtcatggagcacaggttcttcctcagcatcaactggcaggacgtggtccagaag
aagctcctgccacccttcaaacctcaggtcacgtccgaggtcgacacaaggtacttcgat
gatgaatttaccgcccagtccatcacaatcacaccccctgaccgctatgacagcctgggc
ttactggagctggaccagcggacccacttcccccagttctcctactcggccagcatccgc
gagtga

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