KEGG T01001: 10014

Homo sapiens (human): 10014

Entry

10014 CDS T01001

Gene name

HDAC5, HD5, NY-CO-9

Definition

histone deacetylase 5 (EC:3.5.1.98)

Orthology

K11406

histone deacetylase 4/5 [EC:3.5.1.98]

Organism

hsa Homo sapiens (human)

Pathway

hsa05034	Alcoholism
hsa05169	Epstein-Barr virus infection
hsa05203	Viral carcinogenesis

Drug target

Romidepsin:

D06637

Panobinostat:

D10019

Valproic acid:

D00304 D00399 D00710 D08667

Other:

D08870 D10060 D10084 D10319

Class

Human Diseases; Cancers; Viral carcinogenesis [PATH:hsa05203]
Human Diseases; Substance dependence; Alcoholism [PATH:hsa05034]
Human Diseases; Infectious diseases; Epstein-Barr virus infection [PATH:hsa05169]

SSDB

Motif

Pfam:

Hist_deacetyl HDAC4_Gln Arb2

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Position

17q21

AA seq 1123 aa
MNSPNESADGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVEL
RGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQ
QQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIA
STEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYK
LPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVE
ITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPN
QFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMS
TSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVAT
SMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTG
ELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEE
DCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRT
QSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQ
ETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVL
PCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTA
MGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGN
FFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLV
SAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACV
SALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGE
TEEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL

NT seq 3372 nt +upstreamnt +downstreamnt
atgaactctcccaacgagtcggcagatgggatgtcaggtcgggaaccatccttggaaatc
ctgccgcggacttctctgcacagcatccctgtgacagtggaggtgaagccggtgctgcca
agagccatgcccagttccatggggggtgggggtggaggcagccccagccctgtggagcta
cggggggctctggtgggctctgtggaccccacactgcgggagcagcaactgcagcaggag
ctcctggcgctcaagcagcagcagcagctgcagaagcagctcctgttcgctgagttccag
aaacagcatgaccacctgacaaggcagcatgaggtccagctgcagaagcacctcaagcag
cagcaggagatgctggcagccaagcagcagcaggagatgctggcagccaagcggcagcag
gagctggagcagcagcggcagcgggagcagcagcggcaggaagagctggagaagcagcgg
ctggagcagcagctgctcatcctgcggaacaaggagaagagcaaagagagtgccattgcc
agcactgaggtaaagctgaggctccaggaattcctcttgtcgaagtcaaaggagcccaca
ccaggcggcctcaaccattccctcccacagcaccccaaatgctggggagcccaccatgct
tctttggaccagagttcccctccccagagcggcccccctgggacgcctccctcctacaaa
ctgcctttgcctgggccctacgacagtcgagacgacttccccctccgcaaaacagcctct
gaacccaacttgaaagtgcgttcaaggctaaaacagaaggtggctgagcggagaagcagt
cccctcctgcgtcgcaaggatgggactgttattagcacctttaagaagagagctgttgag
atcacaggtgccgggcctggggcgtcgtccgtgtgtaacagcgcacccggctccggcccc
agctctcccaacagctcccacagcaccatcgctgagaatggctttactggctcagtcccc
aacatccccactgagatgctccctcagcaccgagccctccctctggacagctcccccaac
cagttcagcctctacacgtctccttctctgcccaacatctccctagggctgcaggccacg
gtcactgtcaccaactcacacctcactgcctccccgaagctgtcgacacagcaggaggcc
gagaggcaggccctccagtccctgcggcagggtggcacgctgaccggcaagttcatgagc
acatcctctattcctggctgcctgctgggcgtggcactggagggcgacgggagcccccac
gggcatgcctccctgctgcagcatgtgctgttgctggagcaggcccggcagcagagcacc
ctcattgctgtgccactccacgggcagtccccactagtgacgggtgaacgtgtggccacc
agcatgcggacggtaggcaagctcccgcggcatcggcccctgagccgcactcagtcctca
ccgctgccgcagagtccccaggccctgcagcagctggtcatgcaacaacagcaccagcag
ttcctggagaagcagaagcagcagcagctacagctgggcaagatcctcaccaagacaggg
gagctgcccaggcagcccaccacccaccctgaggagacagaggaggagctgacggagcag
caggaggtcttgctgggggagggagccctgaccatgccccgggagggctccacagagagt
gagagcacacaggaagacctggaggaggaggacgaggaagacgatggggaggaggaggag
gattgcatccaggttaaggacgaggagggcgagagtggtgctgaggaggggcccgacttg
gaggagcctggtgctggatacaaaaaactgttctcagatgcccagccgctgcagcctttg
caggtgtaccaggcgcccctcagcctggccactgtgccccaccaggccctgggccgtacc
cagtcctcccctgctgcccctgggggcatgaagagccccccagaccagcccgtcaagcac
ctcttcaccacaggtgtggtctacgacacgttcatgctaaagcaccagtgcatgtgcggg
aacacacacgtgcaccctgagcatgctggccggatccagagcatctggtcccggctgcag
gagacaggcctgcttagcaagtgcgagcggatccgaggtcgcaaagccacgctagatgag
atccagacagtgcactctgaataccacaccctgctctatgggaccagtcccctcaaccgg
cagaagctagacagcaagaagttgctcggccccatcagccagaagatgtatgctgtgctg
ccttgtgggggcatcggggtggacagtgacaccgtgtggaatgagatgcactcctccagt
gctgtgcgcatggcagtgggctgcctgctggagctggccttcaaggtggctgcaggagag
ctcaagaatggatttgccatcatccggcccccaggacaccacgccgaggaatccacagcc
atgggattctgcttcttcaactctgtagccatcaccgcaaaactcctacagcagaagttg
aacgtgggcaaggtcctcatcgtggactgggacattcaccatggcaatggcacccagcag
gcgttctacaatgacccctctgtgctctacatctctctgcatcgctatgacaacgggaac
ttctttccaggctctggggctcctgaagaggttggtggaggaccaggcgtggggtacaat
gtgaacgtggcatggacaggaggtgtggacccccccattggagacgtggagtaccttaca
gccttcaggacagtggtgatgcccattgcccacgagttctcacctgatgtggtcctagtc
tccgccgggtttgatgctgttgaaggacatctgtctcctctgggtggctactctgtcacc
gccagatgttttggccacttgaccaggcagctgatgaccctggcagggggccgggtggtg
ctggccctggagggaggccatgacttgaccgccatctgtgatgcctctgaggcttgtgtc
tcggctctgctcagtgtagagctgcagcccttggatgaggcagtcttgcagcaaaagccc
aacatcaacgcagtggccacgctagagaaagtcatcgagatccagagcaaacactggagc
tgtgtgcagaagttcgccgctggtctgggccggtccctgcgagaggcccaagcaggtgag
accgaggaggccgagactgtgagcgccatggccttgctgtcggtgggggccgagcaggcc
caggctgcggcagcccgggaacacagccccaggccggcagaggagcccatggagcaggag
cctgccctgtga

All links

Ontology (4)   
   KEGG BRITE (4)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Drug (10)   
   KEGG DRUG (10)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (9)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (35)   
   RefSeq(nuc) (3)   
   GenBank (16)   
   EMBL (16)   
Protein domain (3)   
   Pfam (3)   
All databases (78)   

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