KEGG   Homo sapiens (human): 1025
Entry
1025              CDS       T01001                                 
Symbol
CDK9, C-2k, CDC2L4, CTK1, PITALRE, TAK
Name
(RefSeq) cyclin dependent kinase 9
  KO
K02211  cyclin-dependent kinase 9 [EC:2.7.11.22 2.7.11.23]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03250  Viral life cycle - HIV-1
hsa05202  Transcriptional misregulation in cancer
Network
nt06240  Transcription (cancer)
  Element
N00119  MLL-AF4 fusion to transcriptional activation
Drug target
Dinaciclib: D09604
Enitociclib: D12525
Istisociclib: D12868
Zotiraciclib (DG03058): D11599 D11600
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03250 Viral life cycle - HIV-1
    1025 (CDK9)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    1025 (CDK9)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    1025 (CDK9)
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    1025 (CDK9)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     1025 (CDK9)
    2.7.11.23  [RNA-polymerase]-subunit kinase
     1025 (CDK9)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  CDK family
   1025 (CDK9)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Super elongation complex (SEC)
     1025 (CDK9)
    Brd4/P-TEFb complex
     1025 (CDK9)
    7SK RNP complex
     1025 (CDK9)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Haspin_kinase ABC1
Other DBs
NCBI-GeneID: 1025
NCBI-ProteinID: NP_001252
OMIM: 603251
HGNC: 1780
Ensembl: ENSG00000136807
UniProt: P50750
Structure
Position
9:127786034..127790792
AA seq 372 aa
MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP
ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK
FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS
QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL
ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP
AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNP
ATTNQTEFERVF
NT seq 1119 nt   +upstreamnt  +downstreamnt
atggcaaagcagtacgactcggtggagtgccctttttgtgatgaagtttccaaatacgag
aagctcgccaagatcggccaaggcaccttcggggaggtgttcaaggccaggcaccgcaag
accggccagaaggtggctctgaagaaggtgctgatggaaaacgagaaggaggggttcccc
attacagccttgcgggagatcaagatccttcagcttctaaaacacgagaatgtggtcaac
ttgattgagatttgtcgaaccaaagcttccccctataaccgctgcaagggtagtatatac
ctggtgttcgacttctgcgagcatgaccttgctgggctgttgagcaatgttttggtcaag
ttcacgctgtctgagatcaagagggtgatgcagatgctgcttaacggcctctactacatc
cacagaaacaagatcctgcatagggacatgaaggctgctaatgtgcttatcactcgtgat
ggggtcctgaagctggcagactttgggctggcccgggccttcagcctggccaagaacagc
cagcccaaccgctacaccaaccgtgtggtgacactctggtaccggcccccggagctgttg
ctcggggagcgggactacggcccccccattgacctgtggggtgctgggtgcatcatggca
gagatgtggacccgcagccccatcatgcagggcaacacggagcagcaccaactcgccctc
atcagtcagctctgcggctccatcacccctgaggtgtggccaaacgtggacaactatgag
ctgtacgaaaagctggagctggtcaagggccagaagcggaaggtgaaggacaggctgaag
gcctatgtgcgtgacccatacgcactggacctcatcgacaagctgctggtgctggaccct
gcccagcgcatcgacagcgatgacgccctcaaccacgacttcttctggtccgaccccatg
ccctccgacctcaagggcatgctctccacccacctgacgtccatgttcgagtacttggca
ccaccgcgccggaagggcagccagatcacccagcagtccaccaaccagagtcgcaatccc
gccaccaccaaccagacggagtttgagcgcgtcttctga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (2)   
   KEGG PATHWAY (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Drug (5)   
   KEGG DRUG (5)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
3D Structure (27)   
   PDB (27)   
Protein domain (4)   
   Pfam (4)   
All databases (87)   

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