KEGG   Homo sapiens (human): 10606Help
Entry
10606             CDS       T01001                                 

Gene name
PAICS, ADE2, ADE2H1, AIRC, PAIS
Definition
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (EC:6.3.2.6 4.1.1.21)
Orthology
K01587  
phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:4.1.1.21 6.3.2.6]
Organism
hsa  Homo sapiens (human)
Pathway
Purine metabolism
Metabolic pathways
Module
Inosine monophosphate biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Nucleotide metabolism
   00230 Purine metabolism
    10606 (PAICS)
Enzymes [BR:hsa01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.21  phosphoribosylaminoimidazole carboxylase
     10606 (PAICS)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.6  phosphoribosylaminoimidazolesuccinocarboxamide synthase
     10606 (PAICS)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
4q12
AA seq 425 aa AA seqDB search
MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKI
TSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYK
FYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSW
LPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPE
GLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVT
SAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQ
DVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKI
RECNL
NT seq 1278 nt NT seq  +upstreamnt  +downstreamnt
atggcgacagctgaggtactgaacattggtaaaaaattatatgagggtaaaacaaaagaa
gtctacgaattgttagacagtccaggaaaagtcctcctgcagtccaaggaccagattaca
gcaggaaatgcagctagaaaaaaccacctggaaggaaaagctgcaatctcaaataaaatc
accagttgtatttttcagttattacaggaagcaggtattaaaactgccttcaccagaaaa
tgtggggagacagctttcattgcaccgcagtgtgaaatgattccaattgaatgggtttgc
agaagaatagcaactggttcttttctcaaaagaaatcctggtgtcaaggaaggatataag
ttttacccacctaaagtggagttgtttttcaaggatgatgccaataatgacccacagtgg
tctgaggaacagctgattgctgcaaaattttgctttgctggacttcttataggccagact
gaagtggatatcatgagtcatgctacacaggctatatttgaaatactggagaaatcctgg
ttgccccagaattgtacactggttgatatgaagattgaatttggtgttgatgtaaccacc
aaagaaattgttcttgctgatgttattgacaatgattcctggagactctggccatcagga
gatcgaagccaacagaaagacaaacagtcttatcgggacctcaaagaagtaactcctgaa
gggctccaaatggtaaagaaaaactttgagtgggttgcagagagagtagagttgcttttg
aaatcagaaagtcagtgcagggttgtagtgttgatgggctctacttctgatcttggtcac
tgtgaaaaaatcaagaaggcctgtggaaattttggcattccatgtgaacttcgagtaaca
tctgcgcataaaggaccagatgaaactctgaggattaaagctgagtatgaaggggatggc
attcctactgtatttgtggcagtggcaggcagaagtaatggtttgggaccagtgatgtct
gggaacactgcatatccagttatcagctgtcctcccctcacaccagactggggagttcag
gatgtgtggtcttctcttcgactacccagtggtcttggctgttcaaccgtactttctcca
gaaggatcagctcaatttgctgctcagatatttgggttaagcaaccatttggtatggagc
aaactgcgagcaagcattttgaacacatggatttccttgaagcaggctgacaagaaaatc
agagaatgtaatttataa

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