KEGG   Homo sapiens (human): 1103Help
Entry
1103              CDS       T01001                                 

Gene name
CHAT, CHOACTASE, CMS1A, CMS1A2, CMS6
Definition
(RefSeq) choline O-acetyltransferase
  KO
K00623  choline O-acetyltransferase [EC:2.3.1.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse
Disease
H00770  Congenital myasthenic syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Lipid metabolism
   00564 Glycerophospholipid metabolism
    1103 (CHAT)
 Organismal Systems
  Nervous system
   04725 Cholinergic synapse
    1103 (CHAT)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.6  choline O-acetyltransferase
     1103 (CHAT)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Carn_acyltransf
Motif
Other DBs
NCBI-GeneID: 1103
NCBI-ProteinID: NP_065574
OMIM: 118490
HGNC: 1912
Ensembl: ENSG00000070748
Vega: OTTHUMG00000018198
Pharos: P28329(Tchem)
UniProt: P28329
Structure
PDB: 

Jmol
Position
10q11.23
AA seq 748 aa AA seqDB search
MGLRTAKKRGLGGGGKWKREEGGGTRGRREVRPACFLQSGGRGDPGDVGGPAGNPGCSPH
PRAATRPPPLPAHTPAHTPEWCGAASAEAAEPRRAGPHLCIPAPGLTKTPILEKVPRKMA
AKTPSSEESGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQ
QKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLIS
GVLSYKALLDSHSIPTDCAKGQLSGQPLCMKQYYGLFSSYRLPGHTQDTLVAQNSSIMPE
PEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNEDERLPPIGLLTSDGRSE
WAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANR
WYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMTQSSRKLIRADSVSELPAP
RRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQ
LAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLL
KDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCKELPEMFMDETYLMSNRFVLSTSQV
PTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCKETSSSKFAKAVEESLIDMRD
LCSLLPPTESKPLATKEKATRPSQGHQP
NT seq 2247 nt NT seq  +upstreamnt  +downstreamnt
atggggctgaggacagcgaagaagagggggcttgggggaggggggaaatggaagagagag
gagggaggaggtacaagaggaaggagagaagtgcggccagcttgctttctccagtcgggt
ggccgcggggacccgggcgacgtcggaggccctgccgggaacccaggctgcagcccccac
ccccgcgctgcgacacgccccccaccccttccggctcacacccccgcccacactcctgag
tggtgcggtgcagcgtcggccgaggcagcagagccgaggagagcaggtccacacctctgc
atccctgcaccaggactcaccaagacgcccatcctggaaaaggtcccccgtaagatggca
gcaaaaactcccagcagtgaggagtctgggctgcccaaactgcccgtgcccccgctgcag
cagaccctggccacgtacctgcagtgcatgcgacacttggtgtctgaggagcagttcagg
aagagccaggccattgtgcagcagtttggggcccctggtggcctcggcgagaccctgcag
cagaaactcctggagcggcaggagaagacagccaactgggtgtctgagtactggctgaat
gacatgtatctcaacaaccgcctggccctgcctgtcaactccagccctgccgtgatcttt
gctcggcagcacttccctggcaccgatgaccagctgaggtttgcagccagcctcatctct
ggtgtactcagctacaaggccctgctggacagccactccattcccactgactgtgccaaa
ggccagctgtcagggcagcccctttgcatgaagcaatactatgggctcttctcctcctac
cggctccccggccatacccaggacacgctggtggctcagaacagcagcatcatgccggag
cctgagcacgtcatcgtagcctgctgcaatcagttctttgtcttggatgttgtcattaat
ttccgccgtctcagtgagggggatctgttcactcagttgagaaagatagtcaaaatggct
tccaacgaggacgagcgtttgcctccaattggcctgctgacgtctgacgggaggagcgag
tgggccgaggccaggacggtcctcgtgaaagactccaccaaccgggactcgctggacatg
attgagcgctgcatctgccttgtatgcctggacgcgccaggaggcgtggagctcagcgac
acccacagggcactccagctccttcacggcggaggctacagcaagaacggggccaatcgc
tggtacgacaagtccctgcagtttgtggtgggccgagacggcacctgcggtgtggtgtgc
gaacactccccattcgatggcatcgtcctggtgcagtgcactgagcatctgctcaagcac
atgacgcagagcagcaggaagctgatccgagcagactccgtcagcgagctccccgccccc
cggaggctgcggtggaaatgctccccggaaattcaaggccacttagcctcctcggcagaa
aaacttcaacgaatagtaaagaaccttgacttcattgtctataagtttgacaactatggg
aaaacattcattaagaagcagaaatgcagccctgatgccttcatccaggtggccctccag
ctggccttctacaggctccatcgaagactggtgcccacctacgagagcgcgtccatccgc
cgattccaggagggacgcgtggacaacatcagatcggccactccagaggcactggctttt
gtgagagccgtgactgaccacaaggctgctgtgccagcttctgagaagcttctgctcctg
aaggatgccatccgtgcccagactgcatacacagtcatggccataacagggatggccatt
gacaaccacctgctggcactgcgggagctggcccgggccatgtgcaaggagctgcccgag
atgttcatggatgaaacctacctgatgagcaaccggtttgtcctctccactagccaggtg
cccacaaccacggagatgttctgctgctatggtcctgtggtcccaaatgggtatggtgcc
tgctacaacccccagccagagaccatccttttctgcatctctagctttcacagctgcaaa
gagacttcttctagcaagtttgcaaaagctgtggaagaaagcctcattgacatgagagac
ctctgcagtctgctgccgcctactgagagcaagccattggcaacaaaggaaaaagccacg
aggcccagccagggacaccaaccttga

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