KEGG T01001: 11200

Homo sapiens (human): 11200

Entry

11200 CDS T01001

Gene name

CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1

Definition

checkpoint kinase 2 (EC:2.7.11.1)

Orthology

K06641

serine/threonine-protein kinase Chk2 [EC:2.7.11.1]

Organism

hsa Homo sapiens (human)

Pathway

hsa04110	Cell cycle
hsa04115	p53 signaling pathway
hsa05166	HTLV-I infection

Disease

H00881

Li-Fraumeni syndrome

Class

Cellular Processes; Cell growth and death; Cell cycle [PATH:hsa04110]
Cellular Processes; Cell growth and death; p53 signaling pathway [PATH:hsa04115]
Human Diseases; Infectious diseases; HTLV-I infection [PATH:hsa05166]

SSDB

Motif

Pfam:

Pkinase Pkinase_Tyr FHA Kinase-like Pox_ser-thr_kin YrbL-PhoP_reg Kdo RIO1 DUF966

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

2YCF 2YIQ 2YCQ 2W0J 2W7X 2YIR 2WTJ 2YIT 2YCR 2CN5 2XBJ 2YCS 2XK9 4A9U 2XM9 2WTI 4A9S 4A9T 2WTD 4A9R 2WTC 3I6U 3I6W 2XM8 2CN8 1GXC

Position

22q12.1

AA seq 586 aa
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLETESGHVTQSDLEL
LLSSDPPASASQSAGIRGVRHHPRPVCSLKCVNDNYWFGRDKSCEYCFDEPLLKRTDKYR
TYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNK
VFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFA
IGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNK
RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGE
TSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLK
DQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQD
LLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL

NT seq 1761 nt +upstreamnt +downstreamnt
atgtctcgggagtcggatgttgaggctcagcagtctcatggcagcagtgcctgttcacag
ccccatggcagcgttacccagtcccaaggctcctcctcacagtcccagggcatatccagc
tcctctaccagcacgatgccaaactccagccagtcctctcactccagctctgggacactg
agctccttagagacagtgtccactcaggaactctattctattcctgaggaccaagaacct
gaggaccaagaacctgaggagcctacccctgccccctgggctcgattatgggcccttcag
gatggatttgccaatcttgagacagagtctggccatgttacccaatctgatcttgaactc
ctgctgtcatctgatcctcctgcctcagcctcccaaagtgctgggataagaggtgtgagg
caccatccccggccagtttgcagtctaaaatgtgtgaatgacaactactggtttgggagg
gacaaaagctgtgaatattgctttgatgaaccactgctgaaaagaacagataaataccga
acatacagcaagaaacactttcggattttcagggaagtgggtcctaaaaactcttacatt
gcatacatagaagatcacagtggcaatggaacctttgtaaatacagagcttgtagggaaa
ggaaaacgccgtcctttgaataacaattctgaaattgcactgtcactaagcagaaataaa
gtttttgtcttttttgatctgactgtagatgatcagtcagtttatcctaaggcattaaga
gatgaatacatcatgtcaaaaactcttggaagtggtgcctgtggagaggtaaagctggct
ttcgagaggaaaacatgtaagaaagtagccataaagatcatcagcaaaaggaagtttgct
attggttcagcaagagaggcagacccagctctcaatgttgaaacagaaatagaaattttg
aaaaagctaaatcatccttgcatcatcaagattaaaaacttttttgatgcagaagattat
tatattgttttggaattgatggaagggggagagctgtttgacaaagtggtggggaataaa
cgcctgaaagaagctacctgcaagctctatttttaccagatgctcttggctgtgcagtac
cttcatgaaaacggtattatacaccgtgacttaaagccagagaatgttttactgtcatct
caagaagaggactgtcttataaagattactgattttgggcactccaagattttgggagag
acctctctcatgagaaccttatgtggaacccccacctacttggcgcctgaagttcttgtt
tctgttgggactgctgggtataaccgtgctgtggactgctggagtttaggagttattctt
tttatctgccttagtgggtatccacctttctctgagcataggactcaagtgtcactgaag
gatcagatcaccagtggaaaatacaacttcattcctgaagtctgggcagaagtctcagag
aaagctctggaccttgtcaagaagttgttggtagtggatccaaaggcacgttttacgaca
gaagaagccttaagacacccgtggcttcaggatgaagacatgaagagaaagtttcaagat
cttctgtctgaggaaaatgaatccacagctctaccccaggttctagcccagccttctact
agtcgaaagcggccccgtgaaggggaagccgagggtgccgagaccacaaagcgcccagct
gtgtgtgctgctgtgttgtga

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (6)   
   KEGG DISEASE (1)   
   OMIM (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (36)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (27)   
   UniGene (2)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (4)   
DNA sequence (60)   
   RefSeq(nuc) (4)   
   GenBank (28)   
   EMBL (28)   
3D Structure (26)   
   PDB (26)   
Protein domain (9)   
   Pfam (9)   
All databases (148)   

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