KEGG   Homo sapiens (human): 1128Help
Entry
1128              CDS       T01001                                 

Gene name
CHRM1, HM1, M1, M1R
Definition
(RefSeq) cholinergic receptor muscarinic 1
  KO
K04129  
muscarinic acetylcholine receptor M1
Organism
hsa  Homo sapiens (human)
Pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
Drug target
Pirenzepine [DG:DG00026]: 
Mebeverine [DG:DG00030]: 
Trimebutine [DG:DG00031]: 
Dicycloverine [DG:DG00032]: 
Dihexyverine [DG:DG00033]: 
Piperidolate [DG:DG00034]: 
Propantheline [DG:DG00035]: 
Methantheline [DG:DG00036]: 
Tridihexethyl [DG:DG00037]: 
Isopropamide [DG:DG00038]: 
Hexocyclium [DG:DG00039]: 
Mepenzolate [DG:DG00040]: 
Tiemonium iodide: 
Prifinium bromide: 
Timepidium bromide [DG:DG00041]: 
Valethamate: 
Atropine [DG:DG00052]: 
Hyoscyamine [DG:DG00053]: 
Butylscopolamine: 
Methylatropine [DG:DG01242]: 
Methylscopolamine: 
Fentonium: 
Cimetropium bromide: 
Scopolamine [DG:DG00065]: 
Oxybutynin [DG:DG00478]: 
Propiverine [DG:DG00479]: 
Trospium: 
Fesoterodine [DG:DG00483]: 
Orphenadrine (citrate): 
Trihexyphenidyl [DG:DG00851]: 
Biperiden [DG:DG00852]: 
Metixene [DG:DG00853]: 
Procyclidine [DG:DG00854]: 
Profenamine [DG:DG00855]: 
Dexetimide [DG:DG00856]: 
Mazaticol [DG:DG00857]: 
Orphenadrine (chloride): 
Benzatropine [DG:DG00859]: 
Etybenzatropine: 
Chlorpromazine [DG:DG00867]: 
Carbachol: 
Bethanechol [DG:DG00991]: 
Pilocarpine [DG:DG00992]: 
Choline alfoscerate: 
Cevimeline [DG:DG00993]: 
Ipratropium bromide: 
Oxitropium bromide: 
Aclidinium bromide: 
Umeclidinium bromide: 
Aceclidine: 
Acetylcholine [DG:DG01133]: 
Cyclopentolate [DG:DG01141]: 
Homatropine [DG:DG01142]: 
Tropicamide: 
Other: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04020 Calcium signaling pathway
    1128 (CHRM1)
   04024 cAMP signaling pathway
    1128 (CHRM1)
   04151 PI3K-Akt signaling pathway
    1128 (CHRM1)
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1128 (CHRM1)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    1128 (CHRM1)
 Organismal Systems
  Nervous system
   04725 Cholinergic synapse
    1128 (CHRM1)
G protein-coupled receptors [BR:hsa04030]
 Class A. Rhodopsin family
  Biogenic amine [Fig]
   Acetylcholine (muscarinic) [OT]
    1128 (CHRM1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Position
11q13
AA seq 460 aa AA seqDB search
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
NT seq 1383 nt NT seq  +upstreamnt  +downstreamnt
atgaacacttcagccccacctgctgtcagccccaacatcaccgtcctggcaccaggaaag
ggtccctggcaagtggccttcattgggatcaccacgggcctcctgtcgctagccacagtg
acaggcaacctgctggtactcatctctttcaaggtcaacacggagctcaagacagtcaat
aactacttcctgctgagcctggcctgtgctgacctcatcatcggtaccttctccatgaac
ctctataccacgtacctgctcatgggccactgggctctgggcacgctggcttgtgacctc
tggctggccctggactatgtggccagcaatgcctccgtcatgaatctgctgctcatcagc
tttgaccgctacttctccgtgactcggcccctgagctaccgtgccaagcgcacaccccgc
cgggcagctctgatgatcggcctggcctggctggtttcctttgtgctctgggccccagcc
atcctcttctggcagtacctggtaggggagcggacagtgctagctgggcagtgctacatc
cagttcctctcccagcccatcatcacctttggcacagccatggctgccttctacctccct
gtcacagtcatgtgcacgctctactggcgcatctaccgggagacagagaaccgagcacgg
gagctggcagcccttcagggctccgagacgccaggcaaagggggtggcagcagcagcagc
tcagagaggtctcagccaggggctgagggctcaccagagactcctccaggccgctgctgt
cgctgctgccgggcccccaggctgctgcaggcctacagctggaaggaagaagaggaagag
gacgaaggctccatggagtccctcacatcctcagagggagaggagcctggctccgaagtg
gtgatcaagatgccaatggtggaccccgaggcacaggcccccaccaagcagcccccacgg
agctccccaaatacagtcaagaggccgactaagaaagggcgtgatcgagctggcaagggc
cagaagccccgtggaaaggagcagctggccaagcggaagaccttctcgctggtcaaggag
aagaaggcggctcggaccctgagtgccatcctcctggccttcatcctcacctggacaccg
tacaacatcatggtgctggtgtccaccttctgcaaggactgtgttcccgagaccctgtgg
gagctgggctactggctgtgctacgtcaacagcaccatcaaccccatgtgctacgcactc
tgcaacaaagccttccgggacacctttcgcctgctgctgctttgccgctgggacaagaga
cgctggcgcaagatccccaagcgccctggctccgtgcaccgcactccctcccgccaatgc
tga

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