KEGG   Homo sapiens (human): 1129Help
Entry
1129              CDS       T01001                                 

Gene name
CHRM2, HM2
Definition
cholinergic receptor, muscarinic 2
Orthology
K04130  
muscarinic acetylcholine receptor M2
Organism
hsa  Homo sapiens (human)
Pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
Drug target
Mebeverine: 
Trimebutine: 
Dihexyverine: 
Piperidolate: 
Propantheline: 
Methantheline: 
Tridihexethyl: 
Isopropamide: 
Hexocyclium: 
Mepenzolate: 
Tiemonium iodide: 
Prifinium bromide: 
Timepidium bromide: 
Atropine: 
Hyoscyamine: 
Butylscopolamine: 
Methylatropine: 
Methylscopolamine: 
Fentonium: 
Cimetropium bromide: 
Scopolamine: 
Oxybutynin: 
Propiverine: 
Trospium: 
Fesoterodine: 
Orphenadrine (citrate): 
Trihexyphenidyl: 
Biperiden: 
Metixene: 
Procyclidine: 
Profenamine: 
Dexetimide: 
Mazaticol: 
Orphenadrine (chloride): 
Benzatropine: 
Etybenzatropine: 
Chlorpromazine: 
Carbachol: 
Bethanechol: 
Pilocarpine: 
Choline alfoscerate: 
Ipratropium bromide: 
Oxitropium bromide: 
Aclidinium bromide: 
Acetylcholine: 
Cyclopentolate: 
Homatropine: 
Tropicamide: 
Other: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04020 Calcium signaling pathway
    1129 (CHRM2)
   04024 cAMP signaling pathway
    1129 (CHRM2)
   04151 PI3K-Akt signaling pathway
    1129 (CHRM2)
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1129 (CHRM2)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    1129 (CHRM2)
 Organismal Systems
  Nervous system
   04725 Cholinergic synapse
    1129 (CHRM2)
G protein-coupled receptors [BR:hsa04030]
 Class A. Rhodopsin family
  Biogenic amine [Fig]
   Acetylcholine (muscarinic) [OT]
    1129 (CHRM2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
7q31-q35
AA seq 466 aa AA seqDB search
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
NT seq 1401 nt NT seq  +upstreamnt  +downstreamnt
atgaataactcaacaaactcctctaacaatagcctggctcttacaagtccttataagaca
tttgaagtggtgtttattgtcctggtggctggatccctcagtttggtgaccattatcggg
aacatcctagtcatggtttccattaaagtcaaccgccacctccagaccgtcaacaattac
tttttattcagcttggcctgtgctgaccttatcataggtgttttctccatgaacttgtac
accctctacactgtgattggttactggcctttgggacctgtggtgtgtgacctttggcta
gccctggactatgtggtcagcaatgcctcagttatgaatctgctcatcatcagctttgac
aggtacttctgtgtcacaaaacctctgacctacccagtcaagcggaccacaaaaatggca
ggtatgatgattgcagctgcctgggtcctctctttcatcctctgggctccagccattctc
ttctggcagttcattgtaggggtgagaactgtggaggatggggagtgctacattcagttt
ttttccaatgctgctgtcacctttggtacggctattgcagccttctatttgccagtgatc
atcatgactgtgctatattggcacatatcccgagccagcaagagcaggataaagaaggac
aagaaggagcctgttgccaaccaagaccccgtttctccaagtctggtacaaggaaggata
gtgaagccaaacaataacaacatgcccagcagtgacgatggcctggagcacaacaaaatc
cagaatggcaaagcccccagggatcctgtgactgaaaactgtgttcagggagaggagaag
gagagctccaatgactccacctcagtcagtgctgttgcctctaatatgagagatgatgaa
ataacccaggatgaaaacacagtttccacttccctgggccattccaaagatgagaactct
aagcaaacatgcatcagaattggcaccaagaccccaaaaagtgactcatgtaccccaact
aataccaccgtggaggtagtggggtcttcaggtcagaatggagatgaaaagcagaatatt
gtagcccgcaagattgtgaagatgactaagcagcctgcaaaaaagaagcctcctccttcc
cgggaaaagaaagtcaccaggacaatcttggctattctgttggctttcatcatcacttgg
gccccatacaatgtcatggtgctcattaacaccttttgtgcaccttgcatccccaacact
gtgtggacaattggttactggctttgttacatcaacagcactatcaaccctgcctgctat
gcactttgcaatgccaccttcaagaagacctttaaacaccttctcatgtgtcattataag
aacataggcgctacaaggtaa

DBGET integrated database retrieval system