| Entry |
|
|---|
| Gene name |
CHRM4, HM4, M4R
|
|---|
| Definition |
cholinergic receptor, muscarinic 4
|
|---|
| Orthology |
| muscarinic acetylcholine receptor M4 |
|
|---|
| Organism |
|
|---|
| Pathway |
| Neuroactive ligand-receptor interaction | | Cholinergic synapse | | Regulation of actin cytoskeleton |
|
|---|
| Drug target |
Trimebutine: Piperidolate: Propantheline: Methantheline: Tridihexethyl: Isopropamide: Hexocyclium: Mepenzolate: Tiemonium iodide: Prifinium bromide: Timepidium bromide: Atropine: Hyoscyamine: Butylscopolamine: Methylatropine: Methylscopolamine: Fentonium: Cimetropium bromide: Scopolamine: Propiverine: Trospium: Fesoterodine: Orphenadrine (citrate): Trihexyphenidyl: Biperiden: Metixene: Procyclidine: Profenamine: Dexetimide: Mazaticol: Orphenadrine (chloride): Benzatropine: Etybenzatropine: Chlorpromazine: Carbachol: Bethanechol: Pilocarpine: Choline alfoscerate: Ipratropium bromide: Oxitropium bromide: Aclidinium bromide: Acetylcholine: Cyclopentolate: Homatropine: Tropicamide: Other: |
|---|
| Class |
Environmental Information Processing; Signaling molecules and interaction; Neuroactive ligand-receptor interaction [PATH: hsa04080]
Cellular Processes; Cell motility; Regulation of actin cytoskeleton [PATH: hsa04810]
Organismal Systems; Nervous system; Cholinergic synapse [PATH: hsa04725]
 |
|---|
| SSDB |
   |
|---|
| Motif |
 |
|---|
| Other DBs |
NCBI-GI: NCBI-GeneID: OMIM: HGNC: HPRD: Ensembl: Vega: UniProt: |
|---|
| Position |
11p12-p11.2
|
|---|
| AA seq |
479 aa  
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR |
|---|
| NT seq |
1440 nt  +upstreamnt +downstreamnt
atggccaacttcacacctgtcaatggcagctcgggcaatcagtccgtgcgcctggtcacg
tcatcatcccacaatcgctatgagacggtggaaatggtcttcattgccacagtgacaggc
tccctgagcctggtgactgtcgtgggcaacatcctggtgatgctgtccatcaaggtcaac
aggcagctgcagacagtcaacaactacttcctcttcagcctggcgtgtgctgatctcatc
ataggcgccttctccatgaacctctacaccgtgtacatcatcaagggctactggcccctg
ggcgccgtggtctgcgacctgtggctggccctggactacgtggtgagcaacgcctccgtc
atgaaccttctcatcatcagctttgaccgctacttctgcgtcaccaagcctctcacctac
cctgcccggcgcaccaccaagatggcaggcctcatgattgctgctgcctgggtactgtcc
ttcgtgctctgggcgcctgccatcttgttctggcagtttgtggtgggtaagcggacggtg
cccgacaaccagtgcttcatccagttcctgtccaacccagcagtgacctttggcacagcc
attgctgccttctacctgcctgtggtcatcatgacggtgctgtacatccacatctccctg
gccagtcgcagccgagtccacaagcaccggcccgagggcccgaaggagaagaaagccaag
acgctggccttcctcaagagcccactaatgaagcagagcgtcaagaagcccccgcccggg
gaggccgcccgggaggagctgcgcaatggcaagctggaggaggcccccccgccagcgctg
ccaccgccaccgcgccccgtggctgataaggacacttccaatgagtccagctcaggcagt
gccacccagaacaccaaggaacgcccagccacagagctgtccaccacagaggccaccacg
cccgccatgcccgcccctcccctgcagccgcgggccctcaacccagcctccagatggtcc
aagatccagattgtgacgaagcagacaggcaatgagtgtgtgacagccattgagattgtg
cctgccacgccggctggcatgcgccctgcggccaacgtggcccgcaagttcgccagcatc
gctcgcaaccaggtgcgcaagaagcggcagatggcggcccgggagcgcaaagtgacacga
acgatctttgccattctgctagccttcatcctcacctggacgccctacaacgtcatggtc
ctggtgaacaccttctgccagagctgcatccctgacacggtgtggtccattggctactgg
ctctgctacgtcaacagcaccatcaaccctgcctgctatgctctgtgcaacgccaccttt
aaaaagaccttccggcacctgctgctgtgccagtatcggaacatcggcactgccaggtag |
|---|
