KEGG T01001: 1326

Homo sapiens (human): 1326

Entry

1326 CDS T01001

Gene name

MAP3K8, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT

Definition

mitogen-activated protein kinase kinase kinase 8 (EC:2.7.11.25)

Orthology

K04415

mitogen-activated protein kinase kinase kinase 8 [EC:2.7.11.25]

Organism

hsa Homo sapiens (human)

Pathway

hsa04010	MAPK signaling pathway
hsa04620	Toll-like receptor signaling pathway
hsa04660	T cell receptor signaling pathway

Class

Environmental Information Processing; Signal transduction; MAPK signaling pathway [PATH:hsa04010]
Environmental Information Processing; Signal transduction; TNF signaling pathway
Organismal Systems; Immune system; Toll-like receptor signaling pathway [PATH:hsa04620]
Organismal Systems; Immune system; T cell receptor signaling pathway [PATH:hsa04660]

SSDB

Motif

Pfam:

Pkinase Pkinase_Tyr HTH_8 APH

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Position

10p11.23

AA seq 467 aa
MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERS
KSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGR
YQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE
IQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKG
LDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL
CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPG
MRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELP
ENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG

NT seq 1404 nt +upstreamnt +downstreamnt
atggagtacatgagcactggaagtgacaataaagaagagattgatttattaattaaacat
ttaaatgtgtctgatgtaatagacattatggaaaatctttatgcaagtgaagagccagca
gtttatgaacccagtctaatgaccatgtgtcaagacagtaatcaaaacgatgagcgttct
aagtctctgctgcttagtggccaagaggtaccatggttgtcatcagtcagatatggaact
gtggaggatttgcttgcttttgcaaaccatatatccaacactgcaaagcatttttatgga
caacgaccacaggaatctggaattttattaaacatggtcatcactccccaaaatggacgt
taccaaatagattccgatgttctcctgatcccctggaagctgacttacaggaatattggt
tctgattttattcctcggggcgcctttggaaaggtatacttggcacaagatataaagacg
aagaaaagaatggcgtgtaaactgatcccagtagatcaatttaagccatctgatgtggaa
atccaggcttgcttccggcacgagaacatcgcagagctgtatggcgcagtcctgtggggt
gaaactgtccatctctttatggaagcaggcgagggagggtctgttctggagaaactggag
agctgtggaccaatgagagaatttgaaattatttgggtgacaaagcatgttctcaaggga
cttgattttctacactcaaagaaagtgatccatcatgatattaaacctagcaacattgtt
ttcatgtccacaaaagctgttttggtggattttggcctaagtgttcaaatgaccgaagat
gtctattttcctaaggacctccgaggaacagagatttacatgagcccagaggtcatcctg
tgcaggggccattcaaccaaagcagacatctacagcctgggggccacgctcatccacatg
cagacgggcaccccaccctgggtgaagcgctaccctcgctcagcctatccctcctacctg
tacataatccacaagcaagcacctccactggaagacattgcagatgactgcagtccaggg
atgagagagctgatagaagcttccctggagagaaaccccaatcaccgcccaagagccgca
gacctactaaaacatgaggccctgaacccgcccagagaggatcagccacgctgtcagagt
ctggactctgccctcttggagcgcaagaggctgctgagtaggaaggagctggaacttcct
gagaacattgctgattcttcgtgcacaggaagcaccgaggaatctgagatgctcaagagg
caacgctctctctacatcgacctcggcgctctggctggctacttcaatcttgttcgggga
ccaccaacgcttgaatatggctga

All links

Pathway (3)   
   KEGG PATHWAY (3)   
Disease (2)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (10)   
   UniGene (2)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (28)   
   RefSeq(nuc) (2)   
   GenBank (13)   
   EMBL (13)   
Protein domain (4)   
   Pfam (4)   
All databases (61)   

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