KEGG T01001: 1513

Homo sapiens (human): 1513

Entry

1513 CDS T01001

Gene name

CTSK, CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD

Definition

cathepsin K (EC:3.4.22.38)

Orthology

K01371

cathepsin K [EC:3.4.22.38]

Organism

hsa Homo sapiens (human)

Pathway

hsa04142	Lysosome
hsa04380	Osteoclast differentiation
hsa04620	Toll-like receptor signaling pathway
hsa05323	Rheumatoid arthritis

Disease

H00273

Pycnodysostosis

Drug target

Other:

D06634 D08955

Class

Cellular Processes; Transport and catabolism; Lysosome [PATH:hsa04142]
Organismal Systems; Immune system; Toll-like receptor signaling pathway [PATH:hsa04620]
Organismal Systems; Development; Osteoclast differentiation [PATH:hsa04380]
Human Diseases; Immune diseases; Rheumatoid arthritis [PATH:hsa05323]

SSDB

Motif

Pfam:

Peptidase_C1 Inhibitor_I29 Peptidase_C1_2

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

3KWZ 3KX1 4DMY 3O1G 4DMX 1TU6 3O0U 3KW9 3C9E 1MEM 2R6N 2BDL 2ATO 3OVZ 3KWB 1U9X 1Q6K 1U9V 1AYU 1ATK 3H7D 2AUZ 1YT7 1U9W 1BGO 1AYV 1AU4 2AUX 1SNK 1NLJ 1AYW 1YK7 1AU3 1YK8 1BY8 1AU2 1AU0 1NL6 7PCK

Position

1q21

AA seq 329 aa
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM

NT seq 990 nt +upstreamnt +downstreamnt
atgtgggggctcaaggttctgctgctacctgtggtgagctttgctctgtaccctgaggag
atactggacacccactgggagctatggaagaagacccacaggaagcaatataacaacaag
gtggatgaaatctctcggcgtttaatttgggaaaaaaacctgaagtatatttccatccat
aaccttgaggcttctcttggtgtccatacatatgaactggctatgaaccacctgggggac
atgaccagtgaagaggtggttcagaagatgactggactcaaagtacccctgtctcattcc
cgcagtaatgacaccctttatatcccagaatgggaaggtagagccccagactctgtcgac
tatcgaaagaaaggatatgttactcctgtcaaaaatcagggtcagtgtggttcctgttgg
gcttttagctctgtgggtgccctggagggccaactcaagaagaaaactggcaaactctta
aatctgagtccccagaacctagtggattgtgtgtctgagaatgatggctgtggagggggc
tacatgaccaatgccttccaatatgtgcagaagaaccggggtattgactctgaagatgcc
tacccatatgtgggacaggaagagagttgtatgtacaacccaacaggcaaggcagctaaa
tgcagagggtacagagagatccccgaggggaatgagaaagccctgaagagggcagtggcc
cgagtgggacctgtctctgtggccattgatgcaagcctgacctccttccagttttacagc
aaaggtgtgtattatgatgaaagctgcaatagcgataatctgaaccatgcggttttggca
gtgggatatggaatccagaagggaaacaagcactggataattaaaaacagctggggagaa
aactggggaaacaaaggatatatcctcatggctcgaaataagaacaacgcctgtggcatt
gccaacctggccagcttccccaagatgtga

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (2)   
   KEGG DRUG (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (8)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (31)   
   RefSeq(nuc) (1)   
   GenBank (15)   
   EMBL (15)   
3D Structure (39)   
   PDB (39)   
Protein domain (3)   
   Pfam (3)   
All databases (104)   

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