KEGG   Homo sapiens (human): 1571Help
Entry
1571              CDS       T01001                                 

Gene name
CYP2E1, CPE1, CYP2E, P450-J, P450C2E
Definition
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)
Orthology
K07415  
cytochrome P450, family 2, subfamily E, polypeptide 1 [EC:1.14.13.-]
Organism
hsa  Homo sapiens (human)
Pathway
Steroid hormone biosynthesis
Arachidonic acid metabolism
Linoleic acid metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Metabolic pathways
Non-alcoholic fatty liver disease (NAFLD)
Chemical carcinogenesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Lipid metabolism
   00140 Steroid hormone biosynthesis
    1571 (CYP2E1)
   00590 Arachidonic acid metabolism
    1571 (CYP2E1)
   00591 Linoleic acid metabolism
    1571 (CYP2E1)
  Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1571 (CYP2E1)
   00982 Drug metabolism - cytochrome P450
    1571 (CYP2E1)
 Human Diseases
  Cancers
   05204 Chemical carcinogenesis
    1571 (CYP2E1)
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    1571 (CYP2E1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors with incorporation of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-  
     1571 (CYP2E1)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1571 (CYP2E1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
10q26.3
AA seq 493 aa AA seqDB search
MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL
AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP
TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI
ADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA
EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG
TETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRF
ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK
FKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGC
IPPRYKLCVIPRS
NT seq 1482 nt NT seq  +upstreamnt  +downstreamnt
atgtctgccctcggagtcaccgtggccctgctggtgtgggcggccttcctcctgctggtg
tccatgtggaggcaggtgcacagcagctggaatctgcccccaggccctttcccgcttccc
atcatcgggaacctcttccagttggaattgaagaatattcccaagtccttcacccggttg
gcccagcgcttcgggccggtgttcacgctgtacgtgggctcgcagcgcatggtggtgatg
cacggctacaaggcggtgaaggaagcgctgctggactacaaggacgagttctcgggcaga
ggcgacctccccgcgttccatgcgcacagggacaggggaatcatttttaataatggacct
acctggaaggacatccggcggttttccctgaccaccctccggaactatgggatggggaaa
cagggcaatgagagccggatccagagggaggcccacttcctgctggaagcactcaggaag
acccaaggccagcctttcgaccccaccttcctcatcggctgcgcgccctgcaacgtcata
gccgacatcctcttccgcaagcattttgactacaatgatgagaagtttctaaggctgatg
tatttgtttaatgagaacttccacctactcagcactccctggctccagctttacaataat
tttcccagctttctacactacttgcctggaagccacagaaaagtcataaaaaatgtggct
gaagtaaaagagtatgtgtctgaaagggtgaaggagcaccatcaatctctggaccccaac
tgtccccgggacctcaccgactgcctgctcgtggaaatggagaaggaaaagcacagtgca
gagcgcttgtacacaatggacggtatcaccgtgactgtggccgacctgttctttgcgggg
acagagaccaccagcacaactctgagatatgggctcctgattctcatgaaataccctgag
atcgaagagaagctccatgaagaaattgacagggtgattgggccaagccgaatccctgcc
atcaaggataggcaagagatgccctacatggatgctgtggtgcatgagattcagcggttc
atcaccctcgtgccctccaacctgccccatgaagcaacccgagacaccattttcagagga
tacctcatccccaagggcacagtcgtagtgccaactctggactctgttttgtatgacaac
caagaatttcctgatccagaaaagtttaagccagaacacttcctgaatgaaaatggaaag
ttcaagtacagtgactatttcaagccattttccacaggaaaacgagtgtgtgctggagaa
ggcctggctcgcatggagttgtttcttttgttgtgtgccattttgcagcattttaatttg
aagcctctcgttgacccaaaggatatcgacctcagccctatacatattgggtttggctgt
atcccaccacgttacaaactctgtgtcattccccgctcatga

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