KEGG T01001: 1642

Homo sapiens (human): 1642

Entry

1642 CDS T01001

Gene name

DDB1, DDBA, UV-DDB1, XAP1, XPCE, XPE, XPE-BF

Definition

damage-specific DNA binding protein 1, 127kDa

Orthology

K10610

DNA damage-binding protein 1

Organism

hsa Homo sapiens (human)

Pathway

hsa03420	Nucleotide excision repair
hsa04120	Ubiquitin mediated proteolysis
hsa05161	Hepatitis B
hsa05203	Viral carcinogenesis

Module

hsa_M00385	Cul4-DDB1-DDB2 complex
hsa_M00386	Cul4-DDB1-CSA complex

Disease

H00403

Disorders of nucleotide excision repair

Class

Genetic Information Processing; Folding, sorting and degradation; Ubiquitin mediated proteolysis [PATH:hsa04120]
Genetic Information Processing; Replication and repair; Nucleotide excision repair [PATH:hsa03420]
Human Diseases; Cancers; Viral carcinogenesis [PATH:hsa05203]
Human Diseases; Infectious diseases; Hepatitis B [PATH:hsa05161]

SSDB

Motif

Pfam:

MMS1_N CPSF_A Beta_propel

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

3EI3 3E0C 3EI2 3I8C 3I7K 3I7L 3I7N 3I7O 3EI1 2B5N 4E54 2B5L 3I7H 2B5M 4A08 3I89 3I7P 4A09 2HYE 4E5Z 3EI4 4A11 3I8E 4A0A 4A0B 4A0K 4A0L

Position

11q12-q13

AA seq 1140 aa
MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGK
IAVMELFRPKGESKDLLFILTAKYNACILEYKQSGESIDIITRAHGNVQDRIGRPSETGI
IGIIDPECRMIGLRLYDGLFKVIPLDRDNKELKAFNIRLEELHVIDVKFLYGCQAPTICF
VYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYH
NGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDL
RVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIV
DMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDPNRE
TDDTLVLSFVGQTRVLMLNGEEVEETELMGFVDDQQTFFCGNVAHQQLIQITSASVRLVS
QEPKALVSEWKEPQAKNISVASCNSSQVVVAVGRALYYLQIHPQELRQISHTEMEHEVAC
LDITPLGDSNGLSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSH
YLLCALGDGALFYFGLNIETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIY
SSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYES
PRKICYQEVSQCFGVLSSRIEVQDTSGGTTALRPSASTQALSSSVSSSKLFSSSTAPHET
SFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEE
AEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKELR
TECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEIL
DDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGET
STPTQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTER
KTEPATGFIDGDLIESFLDISRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRIH

NT seq 3423 nt +upstreamnt +downstreamnt
atgtcgtacaactacgtggtaacggcccagaagcccaccgccgtgaacggctgcgtgacc
ggacactttacttcggccgaagacttaaacctgttgattgccaaaaacacgagattagag
atctatgtggtcaccgccgaggggcttcggcccgtcaaagaggtgggcatgtatgggaag
attgcggtcatggagcttttcaggcccaagggggagagcaaggacctgctgtttatcttg
acagcgaagtacaatgcctgcatcctggagtataaacagagtggcgagagcattgacatc
attacgcgagcccatggcaatgtccaggaccgcattggccgcccctcagagaccggcatt
attggcatcattgaccctgagtgccggatgattggcctgcgtctctatgatggccttttc
aaggttattccactagatcgcgataataaagaactcaaggccttcaacatccgcctggag
gagctgcatgtcattgatgtcaagttcctatatggttgccaagcacctactatttgcttt
gtctaccaggaccctcaggggcggcacgtaaaaacctatgaggtgtctctccgagaaaag
gaattcaataagggcccttggaaacaggaaaatgtcgaagctgaagcttccatggtgatc
gcagtcccagagccctttgggggggccatcatcattggacaggagtcaatcacctatcac
aatggtgacaaatacctggctattgcccctcctatcatcaagcaaagcacgattgtgtgc
cacaatcgagtggaccctaatggctcaagatacctgctgggagacatggaaggccggctc
ttcatgctgcttttggagaaggaggaacagatggatggcaccgtcactctcaaggatctc
cgtgtagaactccttggagagacctctattgctgagtgcttgacataccttgataatggt
gttgtgtttgtcgggtctcgcctgggtgactcccagcttgtgaagctcaacgttgacagt
aatgaacaaggctcctatgtagtggccatggaaacctttaccaacttaggacccattgtc
gatatgtgcgtggtggacctggagaggcaggggcaggggcagctggtcacttgctctggg
gctttcaaggaaggttctttgcggatcatccggaatggaattggaatccacgagcatgcc
agcattgacttaccaggcatcaaaggattatggccactgcggtctgaccctaatcgtgag
actgatgacactttggtgctctcttttgtgggccagacaagagttctcatgttaaatgga
gaggaggtagaagaaaccgaactgatgggtttcgtggatgatcagcagactttcttctgt
ggcaacgtggctcatcagcagcttatccagatcacttcagcatcggtgaggttggtctct
caagaacccaaagctctggtcagtgaatggaaggagcctcaggccaagaacatcagtgtg
gcctcctgcaatagcagccaggtggtggtggctgtaggcagggccctctactatctgcag
atccatcctcaggagctccggcagatcagccacacagagatggaacatgaagtggcttgc
ttggacatcaccccattaggagacagcaatggactgtcccctctttgtgccattggcctc
tggacggacatctcggctcgtatcttgaagttgccctcttttgaactactgcacaaggag
atgctgggtggagagatcattcctcgctccatcctgatgaccacctttgagagtagccat
tacctcctttgtgccttgggagatggagcgcttttctactttgggctcaacattgagaca
ggtctgttgagcgaccgtaagaaggtgactttgggcacccagcccaccgtattgaggact
tttcgttctctttctaccaccaacgtctttgcttgttctgaccgccccactgtcatctat
agcagcaaccacaaattggtcttctcaaatgtcaacctcaaggaagtgaactacatgtgt
cccctcaattcagatggctatcctgacagcctggcgctggccaacaatagcaccctcacc
attggcaccatcgatgagatccagaagctgcacattcgcacagttcccctctatgagtct
ccaaggaagatctgctaccaggaagtgtcccagtgtttcggggtcctctccagccgcatt
gaagtccaagacacgagtgggggcacgacagccttgaggcccagcgctagcacccaggct
ctgtccagcagtgtaagctccagcaagctgttctccagcagcactgctcctcatgagacc
tcctttggagaagaggtggaggtgcacaacctacttatcattgaccaacacacctttgaa
gtgcttcatgcccaccagtttctgcagaatgaatatgccctcagtctggtttcctgcaag
ctgggcaaagaccccaacacttacttcattgtgggcacagcaatggtgtatcctgaagag
gcagagcccaagcagggtcgcattgtggtctttcagtattcggatggaaaactacagact
gtggctgaaaaggaagtgaaaggggccgtgtactctatggtggaatttaacgggaagctg
ttagccagcatcaatagcacggtgcggctctatgagtggacaacagagaaggagctgcgc
actgagtgcaaccactacaacaacatcatggccctctacctgaagaccaagggcgacttc
atcctggtgggcgaccttatgcgctcagtgctgctgcttgcctacaagcccatggaagga
aactttgaagagattgctcgagactttaatcccaactggatgagtgctgtggaaatcttg
gatgatgacaattttctgggggctgaaaatgcctttaacttgtttgtgtgtcaaaaggat
agcgctgccaccactgacgaggagcggcagcacctccaggaggttggtcttttccacctg
ggcgagtttgtcaatgtcttttgccacggctctctggtaatgcagaatctgggtgagact
tccacccccacacaaggctcggtgctcttcggcacggtcaacggcatgatagggctggtg
acctcactgtcagagagctggtacaacctcctgctggacatgcagaatcgactcaataaa
gtcatcaaaagtgtggggaagatcgagcactccttctggagatcctttcacaccgagcgg
aagacagaaccagccacaggtttcatcgacggtgacttgattgagagtttcctggatatt
agccgccccaagatgcaggaggtggtggcaaacctacagtatgacgatggcagcggtatg
aagcgagaggccactgcagacgacctcatcaaggttgtggaggagctaactcggatccat
tag

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (6)   
   KEGG PATHWAY (4)   
   KEGG MODULE (2)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (14)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (41)   
   RefSeq(nuc) (1)   
   GenBank (20)   
   EMBL (20)   
3D Structure (27)   
   PDB (27)   
Protein domain (3)   
   Pfam (3)   
All databases (105)   

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