KEGG   Homo sapiens (human): 1719Help
Entry
1719              CDS       T01001                                 

Gene name
DHFR, DHFRP1, DYR
Definition
dihydrofolate reductase (EC:1.5.1.3)
Orthology
K00287  
dihydrofolate reductase [EC:1.5.1.3]
Organism
hsa  Homo sapiens (human)
Pathway
One carbon pool by folate
Folate biosynthesis
Metabolic pathways
Disease
H01197  
Dihydrofolate reductase (DHFR) deficiency
Drug target
Methotrexate: 
Pralatrexate: 
Trimetrexate: 
Other: 
Class
Metabolism; Metabolism of cofactors and vitamins; Folate biosynthesis [PATH:hsa00790]
Metabolism; Metabolism of cofactors and vitamins; One carbon pool by folate [PATH:hsa00670]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
5q11.2-q13.2
AA seq 187 aa AA seqDB search
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
NT seq 564 nt NT seq  +upstreamnt  +downstreamnt
atggttggttcgctaaactgcatcgtcgctgtgtcccagaacatgggcatcggcaagaac
ggggacctgccctggccaccgctcaggaatgaattcagatatttccagagaatgaccaca
acctcttcagtagaaggtaaacagaatctggtgattatgggtaagaagacctggttctcc
attcctgagaagaatcgacctttaaagggtagaattaatttagttctcagcagagaactc
aaggaacctccacaaggagctcattttctttccagaagtctagatgatgccttaaaactt
actgaacaaccagaattagcaaataaagtagacatggtctggatagttggtggcagttct
gtttataaggaagccatgaatcacccaggccatcttaaactatttgtgacaaggatcatg
caagactttgaaagtgacacgttttttccagaaattgatttggagaaatataaacttctg
ccagaatacccaggtgttctctctgatgtccaggaggagaaaggcattaagtacaaattt
gaagtatatgagaagaatgattaa

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