KEGG T01001: 1719

Homo sapiens (human): 1719

Entry

1719 CDS T01001

Gene name

DHFR, DHFRP1, DYR

Definition

dihydrofolate reductase (EC:1.5.1.3)

Orthology

K00287

dihydrofolate reductase [EC:1.5.1.3]

Organism

hsa Homo sapiens (human)

Pathway

hsa00670	One carbon pool by folate
hsa00790	Folate biosynthesis
hsa01100	Metabolic pathways

Disease

H01197

Dihydrofolate reductase (DHFR) deficiency

Drug target

Methotrexate:

Pralatrexate:

Trimetrexate:

Other:

Class

Metabolism; Metabolism of cofactors and vitamins; Folate biosynthesis [PATH:hsa00790]
Metabolism; Metabolism of cofactors and vitamins; One carbon pool by folate [PATH:hsa00670]

SSDB

Motif

Pfam:

DHFR_1

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

1KMV 1KMS 3FS6 3GHW 2W3B 3GHV 3GHC 3NXO 3NXR 3NXX 3NTZ 3NU0 3F8Y 2W3A 2C2T 3S3V 3GI2 2W3M 3OAF 3NXT 3GYF 3EIG 3S7A 3NZD 1S3V 1MVT 3NXV 3NXY 3F91 1U72 1S3W 1MVS 3N0H 3L3R 1DRF 3F8Z 4DDR 1PD8 1BOZ 1HFP 1HFQ 1HFR 1U71 1PD9 1PDB 1DLR 1DLS 1DHF 2DHF 1S3U 1OHJ 1OHK 2C2S 1YHO

Position

5q11.2-q13.2

AA seq 187 aa
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND

NT seq 564 nt +upstreamnt +downstreamnt
atggttggttcgctaaactgcatcgtcgctgtgtcccagaacatgggcatcggcaagaac
ggggacctgccctggccaccgctcaggaatgaattcagatatttccagagaatgaccaca
acctcttcagtagaaggtaaacagaatctggtgattatgggtaagaagacctggttctcc
attcctgagaagaatcgacctttaaagggtagaattaatttagttctcagcagagaactc
aaggaacctccacaaggagctcattttctttccagaagtctagatgatgccttaaaactt
actgaacaaccagaattagcaaataaagtagacatggtctggatagttggtggcagttct
gtttataaggaagccatgaatcacccaggccatcttaaactatttgtgacaaggatcatg
caagactttgaaagtgacacgttttttccagaaattgatttggagaaatataaacttctg
ccagaatacccaggtgttctctctgatgtccaggaggagaaaggcattaagtacaaattt
gaagtatatgagaagaatgattaa

All links

Ontology (5)   
   KEGG BRITE (5)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (6)   
   KEGG DRUG (6)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (7)   
   KEGG ENZYME (1)   
   KEGG REACTION (6)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (13)   
   UniGene (2)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (2)   
   RefSeq(pep) (1)   
DNA sequence (33)   
   RefSeq(nuc) (1)   
   GenBank (16)   
   EMBL (16)   
3D Structure (54)   
   PDB (54)   
Protein domain (1)   
   Pfam (1)   
All databases (146)   

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