KEGG   Homo sapiens (human): 1728Help
Entry
1728              CDS       T01001                                 

Gene name
NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1
Definition
(RefSeq) NAD(P)H quinone dehydrogenase 1
  KO
K00355  NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00130  Ubiquinone and other terpenoid-quinone biosynthesis
hsa05200  Pathways in cancer
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
Drug target
Acenocoumarol: D07064
Warfarin (DG00149): D00564 D01280 D08682
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    1728 (NQO1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    1728 (NQO1)
   05225 Hepatocellular carcinoma
    1728 (NQO1)
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    1728 (NQO1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.6  Acting on NADH or NADPH
   1.6.5  With a quinone or similar compound as acceptor
    1.6.5.2  NAD(P)H dehydrogenase (quinone)
     1728 (NQO1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Flavodoxin_2 FMN_red Flavodoxin_4
Motif
Other DBs
NCBI-GeneID: 1728
NCBI-ProteinID: NP_000894
OMIM: 125860
HGNC: 2874
Ensembl: ENSG00000181019
Vega: OTTHUMG00000137575
Pharos: P15559(Tchem)
UniProt: P15559
Structure
PDB: 

Jmol
Position
16q22.1
AA seq 274 aa AA seqDB search
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL
KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV
FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC
GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK
KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
NT seq 825 nt NT seq  +upstreamnt  +downstreamnt
atggtcggcagaagagcactgatcgtactggctcactcagagaggacgtccttcaactat
gccatgaaggaggctgctgcagcggctttgaagaagaaaggatgggaggtggtggagtcg
gacctctatgccatgaacttcaatcccatcatttccagaaaggacatcacaggtaaactg
aaggaccctgcgaactttcagtatcctgccgagtctgttctggcttataaagaaggccat
ctgagcccagatattgtggctgaacaaaagaagctggaagccgcagaccttgtgatattc
cagttccccctgcagtggtttggagtccctgccattctgaaaggctggtttgagcgagtg
ttcataggagagtttgcttacacttacgctgccatgtatgacaaaggacccttccggagt
aagaaggcagtgctttccatcaccactggtggcagtggctccatgtactctctgcaaggg
atccacggggacatgaatgtcattctctggccaattcagagtggcattctgcatttctgt
ggcttccaagtcttagaacctcaactgacatatagcattgggcacactccagcagacgcc
cgaattcaaatcctggaaggatggaagaaacgcctggagaatatttgggatgagacacca
ctgtattttgctccaagcagcctctttgacctaaacttccaggcaggattcttaatgaaa
aaagaggtacaggatgaggagaaaaacaagaaatttggcctttctgtgggccatcacttg
ggcaagtccatcccaactgacaaccagatcaaagctagaaaatga

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