KEGG T01001: 1742

Homo sapiens (human): 1742

Entry

1742 CDS T01001

Gene name

DLG4, PSD95, SAP-90, SAP90

Definition

discs, large homolog 4 (Drosophila)

Orthology

K11828

discs large protein 4

Organism

hsa Homo sapiens (human)

Pathway

hsa04390	Hippo signaling pathway
hsa04724	Glutamatergic synapse
hsa05016	Huntington's disease
hsa05030	Cocaine addiction

Class

Environmental Information Processing; Signal transduction; Hippo signaling pathway [PATH:hsa04390]
Organismal Systems; Nervous system; Glutamatergic synapse [PATH:hsa04724]
Human Diseases; Neurodegenerative diseases; Huntington's disease [PATH:hsa05016]
Human Diseases; Substance dependence; Cocaine addiction [PATH:hsa05030]

SSDB

Motif

Pfam:

Guanylate_kin PDZ PDZ_assoc PDZ_2 MAGUK_N_PEST SH3_1 SH3_2 SH3_9

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

3I4W 3K82 3ZRT 1KEF

Position

17p13.1

AA seq 721 aa
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEY
EEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEV
DVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHI
PGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV
AKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLG
EEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVN
GVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASL
RSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETD
DIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPT
KDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQ
YNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINK
RITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARER
L

NT seq 2166 nt +upstreamnt +downstreamnt
atggactgtctctgtatagtgacaaccaagaaataccgctaccaagatgaagacacgccc
cctctggagcacagcccggcccacctccccaaccaggccaattctcccccagtgattgtc
aacacagataccctagaagccccaggatatgtgaacgggaccgagggggagatggaatac
gaggaaatcacattggaaaggggtaactcaggtctgggcttcagcatcgcaggtggcact
gacaacccacacatcggtgacgacccatccattttcatcaccaagatcattcctggtggg
gctgcggcccaggatggccgcctcagggtcaacgacagcatcctgtttgtaaatgaagtg
gacgtgcgcgaggtgacccactcagcggcggtggaagccctcaaagaggcaggctccatc
gttcgcctctatgtcatgcgccggaagcccccggctgagaaggtcatggagatcaagctc
atcaaggggcctaaaggtcttggcttcagcatcgcagggggcgtagggaaccagcacatc
ccaggagataatagcatctatgtaacaaagatcatcgaagggggtgctgcccacaaggat
gggaggttgcagattggagacaagatcctggcggtcaacagtgtggggctagaggacgtc
atgcatgaagatgctgtggcagccctgaagaacacgtatgatgttgtctacctaaaggtg
gccaagcccagcaatgcctacctgagtgacagctatgctcccccagacatcacaacctct
tattcccagcacctggacaatgagatcagtcacagcagctacctgggcaccgactacccc
acagccatgacccccacttcccctcggcgctactctccagtggccaaggacctgctcggg
gaggaagacattccccgagaaccgaggcgaattgtgatccaccggggctccacgggcctg
ggcttcaacatcgtgggtggcgaggacggtgaaggcatcttcatctcctttatcctggcc
gggggccctgcagacctcagtggggagctgcggaagggggaccagatcctgtcggtcaac
ggtgtggacctccgaaatgccagccatgagcaggctgccattgccctgaagaatgcgggt
cagacggtcacgatcatcgctcagtataaaccagaagagtacagccgattcgaggccaag
atccacgaccttcgggaacagctcatgaacagcagcctgggctcagggactgcgtccctg
cggagcaaccccaaaaggggtttctacatcagggccctgtttgattacgacaagaccaag
gactgcggcttcctgagccaggccctgagcttccgctttggggatgtgctgcatgtcatc
gatgctagtgatgaggagtggtggcaggcacggcgggtccactctgacagtgagaccgac
gacattgggttcatccccagcaaacggcgggttgagcgacgagagtggtcaaggttaaag
gccaaggactggggctccagctctggatcgcagggtcgagaagactcggttctgagctac
gagacagtgacgcagatggaagtgcactatgctcgccccatcatcatccttgggcccacc
aaggaccgcgccaacgatgatcttctctccgagttccccgacaagtttggatcctgtgtt
ccccatacgacacggcccaagcgggagtatgagatagatggccgggattaccactttgtg
tcgtcccgggagaaaatggagaaggacattcaggcgcacaagttcattgaggccggccag
tacaacagccacctctatgggaccagcgtccagtccgtgcgagaggtggcagagcagggg
aagcactgcatcctcgatgtctcggccaatgccgtgcggcggctgcaggcggcccacctg
caccccatcgccatcttcatccgcccccgctccctggagaatgtgctagagattaacaag
cggatcacagaggagcaagcccgcaaagccttcgacagagccaccaagctggagcaggag
ttcacagagtgcttctcagccatcgtggagggtgacagctttgaggagatctaccacaag
gtgaagcgtgtcatcgaggacctctcaggcccctacatctgggttccagcccgagagaga
ctctga

All links

Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (11)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (2)   
   RefSeq(pep) (2)   
DNA sequence (32)   
   RefSeq(nuc) (2)   
   GenBank (15)   
   EMBL (15)   
3D Structure (4)   
   PDB (4)   
Protein domain (8)   
   Pfam (8)   
All databases (73)   

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