KEGG T01001: 1786

Homo sapiens (human): 1786

Entry

1786 CDS T01001

Gene name

DNMT1, AIM, CXXC9, DNMT, HSN1E, MCMT

Definition

DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37)

Orthology

K00558

DNA (cytosine-5-)-methyltransferase [EC:2.1.1.37]

Organism

hsa Homo sapiens (human)

Pathway

hsa00270	Cysteine and methionine metabolism
hsa01100	Metabolic pathways

Module

hsa_M00035

Methionine degradation

Drug target

Azacitidine:

D03021

Decitabine:

D03665

Class

Metabolism; Amino acid metabolism; Cysteine and methionine metabolism [PATH:hsa00270]

SSDB

Motif

Pfam:

DNA_methylase BAH DNMT1-RFD DMAP_binding zf-CXXC

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

3EPZ 3SWR 3PTA

Position

19p13.2

AA seq 1632 aa
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQ
LCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSEARRV
GMADANSPPKPLSKPRTPRRSKSDGEAKRSRDPPASASQVTGIRAEPSPSPRITRKSTRQ
TTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPER
AKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEK
KHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKKMARAKTVM
NSKTHPPKCIQCGQYLDDPDLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQ
HKLTCFSVYCKHGHLCPIDTGLIEKNIELFFSGSAKPIYDDDPSLEGGVNGKNLGPINEW
WITGFDGGEKALIGFSTSFAEYILMDPSPEYAPIFGLMQEKIYISKIVVEFLQSNSDSTY
EDLINKIETTVPPSGLNLNRFTEDSLLRHAQFVVEQVESYDEAGDSDEQPIFLTPCMRDL
IKLAGVTLGQRRAQARRQTIRHSTREKDRGPTKATTTKLVYQIFDTFFAEQIEKDDREDK
ENAFKRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQACQERRCPNMAMKEADDDEE
VDDNIPEMPSPKKMHQGKKKKQNKNRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVS
VIPDDSSKPLYLARVTALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQ
LSYIHSKVKVIYKAPSENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQP
TEDNKFKFCVSCARLAEMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPE
AFTFNIKLSSPVKRPRKEPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKK
SNGRPNETDIKIRVNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEY
GEDLPECVQVYSMGGPNRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQA
CEPSEPEIEIKLPKLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGS
TVFTEDCNILLKLVMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFK
NSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQY
GVAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRT
ITVRDTMSDLPEVRNGASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAAR
MRHIPLAPGSDWRDLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGKA
CDPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQ
HRVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESA
SAKIKEEEAAKD

NT seq 4899 nt +upstreamnt +downstreamnt
atgccggcgcgtaccgccccagcccgggtgcccacactggccgtcccggccatctcgctg
cccgacgatgtccgcaggcggctcaaagatttggaaagagacagcttaacagaaaaggaa
tgtgtgaaggagaaattgaatctcttgcacgaatttctgcaaacagaaataaagaatcag
ttatgtgacttggaaaccaaattacgtaaagaagaattatccgaggagggctacctggct
aaagtcaaatcccttttaaataaagatttgtccttggagaacggtgctcatgcttacaac
cgggaagtgaatggacgtctagaaaacgggaaccaagcaagaagtgaagcccgtagagtg
ggaatggcagatgccaacagcccccccaaacccctttccaaacctcgcacgcccaggagg
agcaagtccgatggagaggctaagcgttcaagagaccctcctgcctcagcctcccaagta
actgggattagagctgaaccttcacctagccccaggattacaaggaaaagcaccaggcaa
accaccatcacatctcattttgcaaagggccctgccaaacggaaacctcaggaagagtct
gaaagagccaaatcggatgagtccatcaaggaagaagacaaagaccaggatgagaagaga
cgtagagttacatccagagaacgagttgctagaccgcttcctgcagaagaacctgaaaga
gcaaaatcaggaacgcgcactgaaaaggaagaagaaagagatgaaaaagaagaaaagaga
ctccgaagtcaaaccaaagaaccaacacccaaacagaaactgaaggaggagccggacaga
gaagccagggcaggcgtgcaggctgacgaggacgaagatggagacgagaaagatgagaag
aagcacagaagtcaacccaaagatctagctgccaaacggaggcccgaagaaaaagaacct
gaaaaagtaaatccacagatttctgatgaaaaagacgaggatgaaaaggaggagaagaga
cgcaaaacgacccccaaagaaccaacggagaaaaaaatggctcgcgccaaaacagtcatg
aactccaagacccaccctcccaagtgcattcagtgcgggcagtacctggacgaccctgac
ctcaaatatgggcagcacccaccagacgcggtggatgagccacagatgctgacaaatgag
aagctgtccatctttgatgccaacgagtctggctttgagagttatgaggcgcttccccag
cacaaactgacctgcttcagtgtgtactgtaagcacggtcacctgtgtcccatcgacacc
ggcctcatcgagaagaatatcgaactcttcttttctggttcagcaaaaccaatctatgat
gatgacccatctcttgaaggtggtgttaatggcaaaaatcttggccccataaatgaatgg
tggatcactggctttgatggaggtgaaaaggccctcatcggcttcagcacctcatttgcc
gaatacattctgatggatcccagtcccgagtatgcgcccatatttgggctgatgcaggag
aagatctacatcagcaagattgtggtggagttcctgcagagcaattccgactcgacctat
gaggacctgatcaacaagatcgagaccacggttcctccttctggcctcaacttgaaccgc
ttcacagaggactccctcctgcgacacgcgcagtttgtggtggagcaggtggagagttat
gacgaggccggggacagtgatgagcagcccatcttcctgacaccctgcatgcgggacctg
atcaagctggctggggtcacgctgggacagaggcgagcccaggcgaggcggcagaccatc
aggcattctaccagggagaaggacaggggacccacgaaagccaccaccaccaagctggtc
taccagatcttcgatactttcttcgcagagcaaattgaaaaggatgacagagaagacaag
gagaacgcctttaagcgccggcgatgtggcgtctgtgaggtgtgtcagcagcctgagtgt
gggaaatgtaaagcctgcaaggacatggttaaatttggtggcagtggacggagcaagcag
gcttgccaagagcggaggtgtcccaatatggccatgaaggaggcagatgacgatgaggaa
gtcgatgataacatcccagagatgccgtcacccaaaaaaatgcaccaggggaagaagaag
aaacagaacaagaatcgcatctcttgggtcggagaagccgtcaagactgatgggaagaag
agttactataagaaggtgtgcattgatgcggaaaccctggaagtgggggactgtgtctct
gttattccagatgattcctcaaaaccgctgtatctagcaagggtcacggcgctgtgggag
gacagcagcaacgggcagatgtttcacgcccactggttctgcgctgggacagacacagtc
ctcggggccacgtcggaccctctggagctgttcttggtggatgaatgtgaggacatgcag
ctttcatatatccacagcaaagtgaaagtcatctacaaagccccctccgaaaactgggcc
atggagggaggcatggatcccgagtccctgctggagggggacgacgggaagacctacttc
taccagctgtggtatgatcaagactacgcgagattcgagtcccctccaaaaacccagcca
acagaggacaacaagttcaaattctgtgtgagctgtgcccgtctggctgagatgaggcaa
aaagaaatccccagggtcctggagcagctcgaggacctggatagccgggtcctctactac
tcagccaccaagaacggcatcctgtaccgagttggtgatggtgtgtacctgccccctgag
gccttcacgttcaacatcaagctgtccagtcccgtgaaacgcccacggaaggagcccgtg
gatgaggacctgtacccagagcactaccggaaatactccgactacatcaaaggcagcaac
ctggatgcccctgagccctaccgaattggccggatcaaagagatcttctgtcccaagaag
agcaacggcaggcccaatgagactgacatcaaaatccgggtcaacaagttctacaggcct
gagaacacccacaagtccactccagcgagctaccacgcagacatcaacctgctctactgg
agcgacgaggaggccgtggtggacttcaaggctgtgcagggccgctgcaccgtggagtat
ggggaggacctgcccgagtgcgtccaggtgtactccatgggcggccccaaccgcttctac
ttcctcgaggcctataatgcaaagagcaaaagctttgaagatcctcccaaccatgcccgt
agccctggaaacaaagggaagggcaagggaaaagggaagggcaagcccaagtcccaagcc
tgtgagccgagcgagccagagatagagatcaagctgcccaagctgcggaccctggatgtg
ttttctggctgcggggggttgtcggagggattccaccaagcaggcatctctgacacgctg
tgggccatcgagatgtgggaccctgcggcccaggcgttccggctgaacaaccccggctcc
acagtgttcacagaggactgcaacatcctgctgaagctggtcatggctggggagaccacc
aactcccgcggccagcggctgccccagaagggagacgtggagatgctgtgcggcgggccg
ccctgccagggcttcagcggcatgaaccgcttcaattcgcgcacctactccaagttcaaa
aactctctggtggtttccttcctcagctactgcgactactaccggccccggttcttcctc
ctggagaatgtcaggaactttgtctccttcaagcgctccatggtcctgaagctcaccctc
cgctgcctggtccgcatgggctatcagtgcaccttcggcgtgctgcaggccggtcagtac
ggcgtggcccagactaggaggcgggccatcatcctggccgcggcccctggagagaagctc
cctctgttcccggagccactgcacgtgtttgctccccgggcctgccagctgagcgtggtg
gtggatgacaagaagtttgtgagcaacataaccaggttgagctcgggtcctttccggacc
atcacggtgcgagacacgatgtccgacctgccggaggtgcggaatggagcctcggcactg
gagatctcctacaacggggagcctcagtcctggttccagaggcagctccggggcgcacag
taccagcccatcctcagggaccacatctgtaaggacatgagtgcattggtggctgcccgc
atgcggcacatccccttggccccagggtcagactggcgcgatctgcccaacatcgaggtg
cggctctcagacggcaccatggccaggaagctgcggtatacccaccatgacaggaagaac
ggccgcagcagctctggggccctccgtggggtctgctcctgcgtggaagccggcaaagcc
tgcgaccccgcagccaggcagttcaacaccctcatcccctggtgcctgccccacaccggg
aaccggcacaaccactgggctggcctctatggaaggctcgagtgggacggcttcttcagc
acaaccgtcaccaaccccgagcccatgggcaagcagggccgcgtgctccacccagagcag
caccgtgtggtgagcgtgcgggagtgtgcccgctcccagggcttccctgacacctaccgg
ctcttcggcaacatcctggacaagcaccggcaggtgggcaatgccgtgccaccgcccctg
gccaaagccattggcttggagatcaagctttgtatgttggccaaagcccgagagagtgcc
tcagctaaaataaaggaggaggaagctgctaaggactag

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (2)   
   KEGG MODULE (1)   
Disease (2)   
   OMIM (2)   
Drug (2)   
   KEGG DRUG (2)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (8)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (2)   
   RefSeq(pep) (2)   
DNA sequence (20)   
   RefSeq(nuc) (2)   
   GenBank (9)   
   EMBL (9)   
3D Structure (3)   
   PDB (3)   
Protein domain (5)   
   Pfam (5)   
All databases (65)   

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