| Entry |
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| Gene name |
DNMT3B, ICF, ICF1, M.HsaIIIB
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| Definition |
DNA (cytosine-5-)-methyltransferase 3 beta (EC:2.1.1.37)
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| Orthology |
| DNA (cytosine-5-)-methyltransferase [EC: 2.1.1.37] |
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| Organism |
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| Pathway |
| Cysteine and methionine metabolism | | Metabolic pathways |
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| Module |
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| Disease |
| Other humoral immunodeficiencies |
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| Drug target |
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| Class |
Metabolism; Amino acid metabolism; Cysteine and methionine metabolism [PATH: hsa00270]
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| SSDB |
   |
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| Motif |
 |
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| Other DBs |
NCBI-GI: NCBI-GeneID: OMIM: HGNC: HPRD: Ensembl: Vega: UniProt: |
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| Structure |
PDB: |
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| Position |
20q11.2
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| AA seq |
728 aa  
MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPASLRRRATASAGTPWPSPP
SSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKE
FGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGL
FSQHFNLATFNKLVSYRKAMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKP
TGIEGLKPNNTQPENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQMAS
DVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCC
EGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDW
NVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYV
ASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARK
GLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMID
AIKVSAAHRARYFWGNLPGMNRIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAP
LKDYFACE |
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| NT seq |
2187 nt  +upstreamnt +downstreamnt
atgaagggagacaccaggcatctcaatggagaggaggacgccggcgggagggaagactcg
atcctcgtcaacggggcctgcagcgaccagtcctccgactcgcccccaatcctggaggct
atccgcaccccggagatcagaggccgaagatcaagctcgcgactctccaagagggaggtg
tccagtctgctaagctacacacaggacttgacaggcgatggcgacggggaagatggggat
ggctctgacaccccagtcatgccaaagctcttccgggaaaccaggactcgttcagaaagc
ccagcttccctgagacggcgggcaacagcatcggcaggaacgccatggccgtcccctccc
agctcttaccttaccatcgacctcacagacgacacagaggacacacatgggacgccccag
agcagcagtaccccctacgcccgcctagcccaggacagccagcaggggggcatggagtcc
ccgcaggtggaggcagacagtggagatggagacagttcagagtatcaggatgggaaggag
tttggaataggggacctcgtgtggggaaagatcaagggcttctcctggtggcccgccatg
gtggtgtcttggaaggccacctccaagcgacaggctatgtctggcatgcggtgggtccag
tggtttggcgatggcaagttctccgaggtctctgcagacaaactggtggcactggggctg
ttcagccagcactttaatttggccaccttcaataagctcgtctcctatcgaaaagccatg
taccatgctctggagaaagctagggtgcgagctggcaagaccttccccagcagccctgga
gactcattggaggaccagctgaagcccatgttggagtgggcccacgggggcttcaagccc
actgggatcgagggcctcaaacccaacaacacgcaaccagagaacaagactcgaagacgc
acagctgacgactcagccacctctgactactgccccgcacccaagcgcctcaagacaaat
tgctataacaacggcaaagaccgaggggatgaagatcagagccgagaacaaatggcttca
gatgttgccaacaacaagagcagcctggaagatggctgtttgtcttgtggcaggaaaaac
cccgtgtccttccaccctctctttgagggggggctctgtcagacatgccgggatcgcttc
cttgagctgttttacatgtatgatgacgatggctatcagtcttactgcactgtgtgctgc
gagggccgagagctgctgctttgcagcaacacgagctgctgccggtgtttctgtgtggag
tgcctggaggtgctggtgggcacaggcacagcggccgaggccaagcttcaggagccctgg
agctgttacatgtgtctcccgcagcgctgtcatggcgtcctgcggcgccggaaggactgg
aacgtgcgcctgcaggccttcttcaccagtgacacggggcttgaatatgaagcccccaag
ctgtaccctgccattcccgcagcccgaaggcggcccattcgagtcctgtcattgtttgat
ggcatcgcgacaggctacctagtcctcaaagagttgggcataaaggtaggaaagtacgtc
gcttctgaagtgtgtgaggagtccattgctgttggaaccgtgaagcacgaggggaatatc
aaatacgtgaacgacgtgaggaacatcacaaagaaaaatattgaagaatggggcccattt
gacttggtgattggcggaagcccatgcaacgatctctcaaatgtgaatccagccaggaaa
ggcctgtatgagggtacaggccggctcttcttcgaattttaccacctgctgaattactca
cgccccaaggagggtgatgaccggccgttcttctggatgtttgagaatgttgtagccatg
aaggttggcgacaagagggacatctcacggttcctggagtgtaatccagtgatgattgat
gccatcaaagtttctgctgctcacagggcccgatacttctggggcaacctacccgggatg
aacaggatctttggctttcctgtgcactacacagacgtgtccaacatgggccgtggtgcc
cgccagaagctgctgggaaggtcctggagcgtgcctgtcatccgacacctcttcgcccct
ctgaaggactactttgcatgtgaatag |
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