KEGG   Homo sapiens (human): 2145
Entry
2145              CDS       T01001                                 
Symbol
EZH1, KMT6B
Name
(RefSeq) enhancer of zeste 1 polycomb repressive complex 2 subunit
  KO
K17451  [histone H3]-lysine27 N-trimethyltransferase EZH1 [EC:2.1.1.356]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00310  Lysine degradation
hsa01100  Metabolic pathways
hsa03083  Polycomb repressive complex
Network
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01577  Gene silencing by methylation of H3K27 and ubiquitination of H2AK119
N01586  Activation of PRC2.2 by ubiquitination of H2AK119
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Drug target
Valemetostat (DG03075): D11551 D11662<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    2145 (EZH1)
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    2145 (EZH1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    2145 (EZH1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.356  [histone H3]-lysine27 N-trimethyltransferase
     2145 (EZH1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     2145 (EZH1)
   Polycomb repressive complex (PRC) and associated proteins
    PRC2.1
     2145 (EZH1)
    PRC2.2
     2145 (EZH1)
SSDB
Motif
Pfam: Ezh2_MCSS PRC2_HTH_1 SET EZH2_WD-Binding preSET_CXC Myb_DNA-binding
Other DBs
NCBI-GeneID: 2145
NCBI-ProteinID: NP_001982
OMIM: 601674
HGNC: 3526
Ensembl: ENSG00000108799
UniProt: Q92800
Structure
Position
17:complement(42700275..42745040)
AA seq 747 aa
MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
KKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAI
ASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCR
RCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGR
RRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPP
QLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILK
LPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMT
QNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVV
SCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYD
KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAG
EELFFDYRYSQADALKYVGIERETDVL
NT seq 2244 nt   +upstreamnt  +downstreamnt
atggaaataccaaatccccctacctccaaatgtatcacttactggaaaagaaaagtgaaa
tctgaatacatgcgacttcgacaacttaaacggcttcaggcaaatatgggtgcaaaggct
ttgtatgtggcaaattttgcaaaggttcaagaaaaaacccagatcctcaatgaagaatgg
aagaagcttcgtgtccaacctgttcagtcaatgaagcctgtgagtggacacccttttctc
aaaaagtgtaccatagagagcattttcccgggatttgcaagccaacatatgttaatgagg
tcactgaacacagttgcattggttcccatcatgtattcctggtcccctctccaacagaac
tttatggtagaagatgagacggttttgtgcaatattccctacatgggagatgaagtgaaa
gaagaagatgagacttttattgaggagctgatcaataactatgatgggaaagtccatggt
gaagaagagatgatccctggatccgttctgattagtgatgctgtttttctggagttggtc
gatgccctgaatcagtactcagatgaggaggaggaagggcacaatgacacctcagatgga
aagcaggatgacagcaaagaagatctgccagtaacaagaaagagaaagcgacatgctatt
gaaggcaacaaaaagagttccaagaaacagttcccaaatgacatgatcttcagtgcaatt
gcctcaatgttccctgagaatggtgtcccagatgacatgaaggagaggtatcgagaacta
acagagatgtcagaccccaatgcacttccccctcagtgcacacccaacatcgatggcccc
aatgccaagtctgtgcagcgggagcaatctctgcactccttccacacacttttttgccgg
cgctgctttaaatacgactgcttccttcacccttttcatgccacccctaatgtatataaa
cgcaagaataaagaaatcaagattgaaccagaaccatgtggcacagactgcttccttttg
ctggaaggagcaaaggagtatgccatgctccacaacccccgctccaagtgctctggtcgt
cgccggagaaggcaccacatagtcagtgcttcctgctccaatgcctcagcctctgctgtg
gctgagactaaagaaggagacagtgacagggacacaggcaatgactgggcctccagttct
tcagaggctaactctcgctgtcagactcccacaaaacagaaggctagtccagccccacct
caactctgcgtagtggaagcaccctcggagcctgtggaatggactggggctgaagaatct
ctttttcgagtcttccatggcacctacttcaacaacttctgttcaatagccaggcttctg
gggaccaagacgtgcaagcaggtctttcagtttgcagtcaaagaatcacttatcctgaag
ctgccaacagatgagctcatgaacccctcacagaagaagaaaagaaagcacagattgtgg
gctgcacactgcaggaagattcagctgaagaaagataactcttccacacaagtgtacaac
taccaaccctgcgaccacccagaccgcccctgtgacagcacctgcccctgcatcatgact
cagaatttctgtgagaagttctgccagtgcaacccagactgtcagaatcgtttccctggc
tgtcgctgtaagacccagtgcaataccaagcaatgtccttgctatctggcagtgcgagaa
tgtgaccctgacctgtgtctcacctgtggggcctcagagcactgggactgcaaggtggtt
tcctgtaaaaactgcagcatccagcgtggacttaagaagcacctgctgctggccccctct
gatgtggccggatggggcaccttcataaaggagtctgtgcagaagaacgaattcatttct
gaatactgtggtgagctcatctctcaggatgaggctgatcgacgcggaaaggtctatgac
aaatacatgtccagcttcctcttcaacctcaataatgattttgtagtggatgctactcgg
aaaggaaacaaaattcgatttgcaaatcattcagtgaatcccaactgttatgccaaagtg
gtcatggtgaatggagaccatcggattgggatctttgccaagagggcaattcaagctggc
gaagagctcttctttgattacaggtacagccaagctgatgctctcaagtacgtggggatc
gagagggagaccgacgtcctttag

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