KEGG   Homo sapiens (human): 2159Help
Entry
2159              CDS       T01001                                 

Gene name
F10, FX, FXA
Definition
(RefSeq) coagulation factor X
  KO
K01314  coagulation factor X [EC:3.4.21.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
Drug target
Antithrombin alfa: D08858
Apixaban: D03213
Betrixaban: D08873
Darexaban maleate: D09817
Edoxaban (DG01398): D09546 D09710
Eribaxaban: D08913
Fidexaban: D04183
Fondaparinux: D01844
Idraparinux sodium: D10471
Letaxaban: D09923
Razaxaban hydrochloride: D04029
Rivaroxaban: D07086
Tifacogin: D06142
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Organismal Systems
  Immune system
   04610 Complement and coagulation cascades
    2159 (F10)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.6  coagulation factor Xa
     2159 (F10)
Peptidases [BR:hsa01002]
 Serine Peptidases
  Family S1: chymotrypsin family
   2159 (F10)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate/Haparin
  Coagulation and fibrinolysis (General comment) Coagulation, inflammation, complement control
   2159 (F10)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Trypsin Gla FXa_inhibition EGF hEGF Trypsin_2 cEGF DUF1986 EGF_2 EGF_3 Fusion_gly
Motif
Other DBs
NCBI-GeneID: 2159
NCBI-ProteinID: NP_000495
OMIM: 613872
HGNC: 3528
Ensembl: ENSG00000126218
Vega: OTTHUMG00000017374
Pharos: P00742(Tclin)
UniProt: P00742 Q5JVE7
Structure
PDB: 

Jmol
Position
13q34
AA seq 488 aa AA seqDB search
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
NT seq 1467 nt NT seq  +upstreamnt  +downstreamnt
atggggcgcccactgcacctcgtcctgctcagtgcctccctggctggcctcctgctgctc
ggggaaagtctgttcatccgcagggagcaggccaacaacatcctggcgagggtcacgagg
gccaattcctttcttgaagagatgaagaaaggacacctcgaaagagagtgcatggaagag
acctgctcatacgaagaggcccgcgaggtctttgaggacagcgacaagacgaatgaattc
tggaataaatacaaagatggcgaccagtgtgagaccagtccttgccagaaccagggcaaa
tgtaaagacggcctcggggaatacacctgcacctgtttagaaggattcgaaggcaaaaac
tgtgaattattcacacggaagctctgcagcctggacaacggggactgtgaccagttctgc
cacgaggaacagaactctgtggtgtgctcctgcgcccgcgggtacaccctggctgacaac
ggcaaggcctgcattcccacagggccctacccctgtgggaaacagaccctggaacgcagg
aagaggtcagtggcccaggccaccagcagcagcggggaggcccctgacagcatcacatgg
aagccatatgatgcagccgacctggaccccaccgagaaccccttcgacctgcttgacttc
aaccagacgcagcctgagaggggcgacaacaacctcaccaggatcgtgggaggccaggaa
tgcaaggacggggagtgtccctggcaggccctgctcatcaatgaggaaaacgagggtttc
tgtggtggaaccattctgagcgagttctacatcctaacggcagcccactgtctctaccaa
gccaagagattcaaggtgagggtaggggaccggaacacggagcaggaggagggcggtgag
gcggtgcacgaggtggaggtggtcatcaagcacaaccggttcacaaaggagacctatgac
ttcgacatcgccgtgctccggctcaagacccccatcaccttccgcatgaacgtggcgcct
gcctgcctccccgagcgtgactgggccgagtccacgctgatgacgcagaagacggggatt
gtgagcggcttcgggcgcacccacgagaagggccggcagtccaccaggctcaagatgctg
gaggtgccctacgtggaccgcaacagctgcaagctgtccagcagcttcatcatcacccag
aacatgttctgtgccggctacgacaccaagcaggaggatgcctgccagggggacagcggg
ggcccgcacgtcacccgcttcaaggacacctacttcgtgacaggcatcgtcagctgggga
gagggctgtgcccgtaaggggaagtacgggatctacaccaaggtcaccgccttcctcaag
tggatcgacaggtccatgaaaaccaggggcttgcccaaggccaagagccatgccccggag
gtcataacgtcctctccattaaagtga

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