| Entry |
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| Gene name |
ALDH1A3, ALDH1A6, ALDH6, MCOP8, RALDH3
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| Definition |
(RefSeq) aldehyde dehydrogenase 1 family member A3
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| KO |
| aldehyde dehydrogenase (NAD(P)+) [EC: 1.2.1.5] |
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| Organism |
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| Pathway |
| Glycolysis / Gluconeogenesis | | Histidine metabolism | | Tyrosine metabolism | | Phenylalanine metabolism | | beta-Alanine metabolism | | Metabolism of xenobiotics by cytochrome P450 | | Drug metabolism - cytochrome P450 | | Metabolic pathways | | Chemical carcinogenesis |
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| Disease |
| Anophthalmia and microphthalmia (A/M) |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
Metabolism
Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
220 (ALDH1A3)
Amino acid metabolism
00340 Histidine metabolism
220 (ALDH1A3)
00350 Tyrosine metabolism
220 (ALDH1A3)
00360 Phenylalanine metabolism
220 (ALDH1A3)
Metabolism of other amino acids
00410 beta-Alanine metabolism
220 (ALDH1A3)
Xenobiotics biodegradation and metabolism
00980 Metabolism of xenobiotics by cytochrome P450
220 (ALDH1A3)
00982 Drug metabolism - cytochrome P450
220 (ALDH1A3)
Human Diseases
Cancers
05204 Chemical carcinogenesis
220 (ALDH1A3)
Enzymes [BR:hsa01000]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.1 With NAD+ or NADP+ as acceptor
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
220 (ALDH1A3)
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| SSDB |
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| Motif |
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| Other DBs |
NCBI-GeneID: NCBI-ProteinID: OMIM: HGNC: Ensembl: Vega: Pharos: UniProt: |
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| Structure |
PDB: |
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| Position |
15q26.3
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| AA seq |
512 aa  
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI
CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM
DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW
NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV
GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE
CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK
QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL
KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF
KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP |
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| NT seq |
1539 nt  +upstreamnt +downstreamnt
atggccaccgctaacggggccgtggaaaacgggcagccggacaggaagccgccggccctg
ccgcgccccatccgcaacctggaggtcaagttcaccaagatatttatcaacaatgaatgg
cacgaatccaagagtgggaaaaagtttgctacatgtaacccttcaactcgggagcaaata
tgtgaagtggaagaaggagataagcccgacgtggacaaggctgtggaggctgcacaggtt
gccttccagaggggctcgccatggcgccggctggatgccctgagtcgtgggcggctgctg
caccagctggctgacctggtggagagggaccgcgccaccttggccgccctggagacgatg
gatacagggaagccatttcttcatgcttttttcatcgacctggagggctgtattagaacc
ctcagatactttgcagggtgggcagacaaaatccagggcaagaccatccccacagatgac
aacgtcgtgtgcttcaccaggcatgagcccattggtgtctgtggggccatcactccatgg
aacttccccctgctgatgctggtgtggaagctggcacccgccctctgctgtgggaacacc
atggtcctgaagcctgcggagcagacacctctcaccgccctttatctcggctctctgatc
aaagaggccgggttccctccaggagtggtgaacattgtgccaggattcgggcccacagtg
ggagcagcaatttcttctcaccctcagatcaacaagatcgccttcaccggctccacagag
gttggaaaactggttaaagaagctgcgtcccggagcaatctgaagcgggtgacgctggag
ctgggggggaagaacccctgcatcgtgtgtgcggacgctgacttggacttggcagtggag
tgtgcccatcagggagtgttcttcaaccaaggccagtgttgcacggcagcctccagggtg
ttcgtggaggagcaggtctactctgagtttgtcaggcggagcgtggagtatgccaagaaa
cggcccgtgggagaccccttcgatgtcaaaacagaacaggggcctcagattgatcaaaag
cagttcgacaaaatcttagagctgatcgagagtgggaagaaggaaggggccaagctggaa
tgcgggggctcagccatggaagacaaggggctcttcatcaaacccactgtcttctcagaa
gtcacagacaacatgcggattgccaaagaggagattttcgggccagtgcaaccaatactg
aagttcaaaagtatcgaagaagtgataaaaagagcgaatagcaccgactatggactcaca
gcagccgtgttcacaaaaaatctcgacaaagccctgaagttggcttctgccttagagtct
ggaacggtctggatcaactgctacaacgccctctatgcacaggctccatttggtggcttt
aaaatgtcaggaaatggcagagaactaggtgaatacgctttggccgaatacacagaagtg
aaaactgtcaccatcaaacttggcgacaagaacccctga |
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