KEGG   Homo sapiens (human): 22800Help
Entry
22800             CDS       T01001                                 

Gene name
RRAS2, TC21
Definition
(RefSeq) RAS related 2
  KO
K07830  
Ras-related protein R-Ras2
Organism
hsa  Homo sapiens (human)
Pathway
MAPK signaling pathway
Ras signaling pathway
cAMP signaling pathway
Phospholipase D signaling pathway
Mitophagy - animal
Autophagy - animal
Cellular senescence
Apelin signaling pathway
Regulation of actin cytoskeleton
HTLV-I infection
Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    22800 (RRAS2)
   04010 MAPK signaling pathway
    22800 (RRAS2)
   04371 Apelin signaling pathway
    22800 (RRAS2)
   04072 Phospholipase D signaling pathway
    22800 (RRAS2)
   04024 cAMP signaling pathway
    22800 (RRAS2)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    22800 (RRAS2)
   04137 Mitophagy - animal
    22800 (RRAS2)
  Cell growth and death
   04218 Cellular senescence
    22800 (RRAS2)
  Cell motility
   04810 Regulation of actin cytoskeleton
    22800 (RRAS2)
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    22800 (RRAS2)
  Infectious diseases
   05166 HTLV-I infection
    22800 (RRAS2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   22800 (RRAS2)
  Exosomal proteins of bladder cancer cells
   22800 (RRAS2)
GTP-binding proteins [BR:hsa04031]
 Small (Monomeric) G-proteins
  Ras Family
   Ras [OT]
    22800 (RRAS2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
P62070(Tbio)
UniProt: 
Structure
PDB: 

Jmol
Position
11p15.2
AA seq 204 aa AA seqDB search
MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDR
AARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEF
PMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQE
QECPPSPEPTRKEKDKKGCHCVIF
NT seq 615 nt NT seq  +upstreamnt  +downstreamnt
atggccgcggccggctggcgggacggctccggccaggagaagtaccggctcgtggtggtc
ggcgggggcggcgtgggcaagtcggcgctcaccatccagttcatccagtcctattttgta
acggattatgatccaaccattgaagattcttacacaaagcagtgtgtgatagatgacaga
gcagcccggctagatattttggatacagcaggacaagaagagtttggagccatgagagaa
cagtatatgaggactggcgaaggcttcctgttggtcttttcagtcacagatagaggcagt
tttgaagaaatctataagtttcaaagacagattctcagagtaaaggatcgtgatgagttc
ccaatgattttaattggtaataaagcagatctggatcatcaaagacaggtaacacaggaa
gaaggacaacagttagcacggcagcttaaggtaacatacatggaggcatcagcaaagatt
aggatgaatgtagatcaagctttccatgaacttgtccgggttatcaggaaatttcaagag
caggaatgtcctccttcaccagaaccaacacggaaagaaaaagacaagaaaggctgccat
tgtgtcattttctag

KEGG   Homo sapiens (human): 22808Help
Entry
22808             CDS       T01001                                 

Gene name
MRAS, M-RAs, R-RAS3, RRAS3
Definition
(RefSeq) muscle RAS oncogene homolog
  KO
K07831  
Ras-related protein M-Ras
Organism
hsa  Homo sapiens (human)
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Phospholipase D signaling pathway
Mitophagy - animal
Autophagy - animal
Cellular senescence
Apelin signaling pathway
Regulation of actin cytoskeleton
HTLV-I infection
Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    22808 (MRAS)
   04015 Rap1 signaling pathway
    22808 (MRAS)
   04010 MAPK signaling pathway
    22808 (MRAS)
   04371 Apelin signaling pathway
    22808 (MRAS)
   04072 Phospholipase D signaling pathway
    22808 (MRAS)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    22808 (MRAS)
   04137 Mitophagy - animal
    22808 (MRAS)
  Cell growth and death
   04218 Cellular senescence
    22808 (MRAS)
  Cell motility
   04810 Regulation of actin cytoskeleton
    22808 (MRAS)
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    22808 (MRAS)
  Infectious diseases
   05166 HTLV-I infection
    22808 (MRAS)
GTP-binding proteins [BR:hsa04031]
 Small (Monomeric) G-proteins
  Ras Family
   Ras [OT]
    22808 (MRAS)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
O14807(Tbio)
UniProt: 
Position
3q22.3
AA seq 208 aa AA seqDB search
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQW
AILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFP
MILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIP
EKSQKKKKKTKWRGDRATGTHKLQCVIL
NT seq 627 nt NT seq  +upstreamnt  +downstreamnt
atggcaaccagcgccgtccccagtgacaacctccccacatacaagctggtggtggtgggg
gatgggggtgtgggcaaaagtgccctcaccatccagtttttccagaagatctttgtgcct
gactatgaccccaccattgaagactcctacctgaaacatacggagattgacaatcaatgg
gccatcttggacgttctggacacagctgggcaggaggaattcagcgccatgcgggagcaa
tacatgcgcacgggggatggcttcctcatcgtctactccgtcactgacaaggccagcttt
gagcacgtggaccgcttccaccagcttatcctgcgcgtcaaagacagggagtcattcccg
atgatcctcgtggccaacaaggtcgatttgatgcacttgaggaagatcaccagggagcaa
ggaaaagaaatggcgaccaaacacaatattccgtacatagaaaccagtgccaaggaccca
cctctcaatgtcgacaaagccttccatgacctcgttagagtaattaggcaacagattccg
gaaaaaagccagaagaagaagaagaaaaccaaatggcggggagaccgggccacaggcacc
cacaaactgcaatgtgtgatcttgtga

KEGG   Homo sapiens (human): 3265Help
Entry
3265              CDS       T01001                                 

Gene name
HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras
Definition
(RefSeq) HRas proto-oncogene, GTPase
  KO
K02833  
GTPase HRas
Organism
hsa  Homo sapiens (human)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Mitophagy - animal
Autophagy - animal
Endocytosis
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Longevity regulating pathway
Longevity regulating pathway - multiple species
Cellular senescence
Axon guidance
VEGF signaling pathway
Apelin signaling pathway
Focal adhesion
Gap junction
Signaling pathways regulating pluripotency of stem cells
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Relaxin signaling pathway
AGE-RAGE signaling pathway in diabetic complications
Alcoholism
Hepatitis C
Hepatitis B
Human papillomavirus infection
HTLV-I infection
Kaposi's sarcoma-associated herpesvirus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Central carbon metabolism in cancer
Choline metabolism in cancer
Disease
H00022  
Bladder cancer
H00025  
Penile cancer
H00030  
Cervical cancer
H00032  
Thyroid cancer
H00040  
Squamous cell carcinoma
H00523  
Noonan syndrome and related disorders
H01470  
Giant cell tumor of bone
H01555  
Merkel cell carcinoma
H01592  
Medullary thyroid cancer
H01666  
Angiosarcoma
H01747  
Costello syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    3265 (HRAS)
   04015 Rap1 signaling pathway
    3265 (HRAS)
   04010 MAPK signaling pathway
    3265 (HRAS)
   04012 ErbB signaling pathway
    3265 (HRAS)
   04370 VEGF signaling pathway
    3265 (HRAS)
   04371 Apelin signaling pathway
    3265 (HRAS)
   04630 Jak-STAT signaling pathway
    3265 (HRAS)
   04068 FoxO signaling pathway
    3265 (HRAS)
   04072 Phospholipase D signaling pathway
    3265 (HRAS)
   04071 Sphingolipid signaling pathway
    3265 (HRAS)
   04151 PI3K-Akt signaling pathway
    3265 (HRAS)
   04150 mTOR signaling pathway
    3265 (HRAS)
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    3265 (HRAS)
   04140 Autophagy - animal
    3265 (HRAS)
   04137 Mitophagy - animal
    3265 (HRAS)
  Cell growth and death
   04210 Apoptosis
    3265 (HRAS)
   04218 Cellular senescence
    3265 (HRAS)
  Cellular community - eukaryotes
   04510 Focal adhesion
    3265 (HRAS)
   04540 Gap junction
    3265 (HRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    3265 (HRAS)
  Cell motility
   04810 Regulation of actin cytoskeleton
    3265 (HRAS)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    3265 (HRAS)
   04660 T cell receptor signaling pathway
    3265 (HRAS)
   04662 B cell receptor signaling pathway
    3265 (HRAS)
   04664 Fc epsilon RI signaling pathway
    3265 (HRAS)
   04062 Chemokine signaling pathway
    3265 (HRAS)
  Endocrine system
   04910 Insulin signaling pathway
    3265 (HRAS)
   04912 GnRH signaling pathway
    3265 (HRAS)
   04915 Estrogen signaling pathway
    3265 (HRAS)
   04917 Prolactin signaling pathway
    3265 (HRAS)
   04921 Oxytocin signaling pathway
    3265 (HRAS)
   04926 Relaxin signaling pathway
    3265 (HRAS)
   04919 Thyroid hormone signaling pathway
    3265 (HRAS)
   04916 Melanogenesis
    3265 (HRAS)
  Nervous system
   04725 Cholinergic synapse
    3265 (HRAS)
   04726 Serotonergic synapse
    3265 (HRAS)
   04720 Long-term potentiation
    3265 (HRAS)
   04730 Long-term depression
    3265 (HRAS)
   04722 Neurotrophin signaling pathway
    3265 (HRAS)
  Development
   04360 Axon guidance
    3265 (HRAS)
  Aging
   04211 Longevity regulating pathway - mammal
    3265 (HRAS)
   04213 Longevity regulating pathway - multiple species
    3265 (HRAS)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    3265 (HRAS)
   05230 Central carbon metabolism in cancer
    3265 (HRAS)
   05231 Choline metabolism in cancer
    3265 (HRAS)
   05206 MicroRNAs in cancer
    3265 (HRAS)
   05205 Proteoglycans in cancer
    3265 (HRAS)
   05203 Viral carcinogenesis
    3265 (HRAS)
   05225 Hepatocellular carcinoma
    3265 (HRAS)
   05214 Glioma
    3265 (HRAS)
   05216 Thyroid cancer
    3265 (HRAS)
   05221 Acute myeloid leukemia
    3265 (HRAS)
   05220 Chronic myeloid leukemia
    3265 (HRAS)
   05218 Melanoma
    3265 (HRAS)
   05211 Renal cell carcinoma
    3265 (HRAS)
   05219 Bladder cancer
    3265 (HRAS)
   05215 Prostate cancer
    3265 (HRAS)
   05213 Endometrial cancer
    3265 (HRAS)
   05224 Breast cancer
    3265 (HRAS)
   05223 Non-small cell lung cancer
    3265 (HRAS)
  Substance dependence
   05034 Alcoholism
    3265 (HRAS)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    3265 (HRAS)
  Infectious diseases
   05166 HTLV-I infection
    3265 (HRAS)
   05161 Hepatitis B
    3265 (HRAS)
   05160 Hepatitis C
    3265 (HRAS)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    3265 (HRAS)
   05165 Human papillomavirus infection
    3265 (HRAS)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    3265 (HRAS)
   01522 Endocrine resistance
    3265 (HRAS)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    3265 (HRAS)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   3265 (HRAS)
  Exosomal proteins of colorectal cancer cells
   3265 (HRAS)
GTP-binding proteins [BR:hsa04031]
 Small (Monomeric) G-proteins
  Ras Family
   Ras [OT]
    3265 (HRAS)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
P01112(Tchem)
UniProt: 
Structure
PDB: 

Jmol
Position
11p15.5
AA seq 189 aa AA seqDB search
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
NT seq 570 nt NT seq  +upstreamnt  +downstreamnt
atgacggaatataagctggtggtggtgggcgccggcggtgtgggcaagagtgcgctgacc
atccagctgatccagaaccattttgtggacgaatacgaccccactatagaggattcctac
cggaagcaggtggtcattgatggggagacgtgcctgttggacatcctggataccgccggc
caggaggagtacagcgccatgcgggaccagtacatgcgcaccggggagggcttcctgtgt
gtgtttgccatcaacaacaccaagtcttttgaggacatccaccagtacagggagcagatc
aaacgggtgaaggactcggatgacgtgcccatggtgctggtggggaacaagtgtgacctg
gctgcacgcactgtggaatctcggcaggctcaggacctcgcccgaagctacggcatcccc
tacatcgagacctcggccaagacccggcagggagtggaggatgccttctacacgttggtg
cgtgagatccggcagcacaagctgcggaagctgaaccctcctgatgagagtggccccggc
tgcatgagctgcaagtgtgtgctctcctga

KEGG   Homo sapiens (human): 3845Help
Entry
3845              CDS       T01001                                 

Gene name
KRAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, KI-RAS, KRAS1, KRAS2, NS, NS3, RALD, RASK2, c-Ki-ras2
Definition
(RefSeq) KRAS proto-oncogene, GTPase
  KO
K07827  
GTPase Kras
Organism
hsa  Homo sapiens (human)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Mitophagy - animal
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Longevity regulating pathway
Longevity regulating pathway - multiple species
Cellular senescence
Axon guidance
VEGF signaling pathway
Apelin signaling pathway
Gap junction
Signaling pathways regulating pluripotency of stem cells
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Relaxin signaling pathway
AGE-RAGE signaling pathway in diabetic complications
Aldosterone-regulated sodium reabsorption
Alcoholism
Hepatitis C
Hepatitis B
Human papillomavirus infection
HTLV-I infection
Kaposi's sarcoma-associated herpesvirus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Central carbon metabolism in cancer
Choline metabolism in cancer
Disease
H00003  
Acute myeloid leukemia (AML)
H00010  
Multiple myeloma
H00014  
Non-small cell lung cancer
H00016  
Oral cancer
H00018  
Gastric cancer
H00019  
Pancreatic cancer
H00020  
Colorectal cancer
H00026  
Endometrial cancer
H00027  
Ovarian cancer
H00030  
Cervical cancer
H00032  
Thyroid cancer
H00040  
Squamous cell carcinoma
H00041  
Kaposi's sarcoma
H00046  
Cholangiocarcinoma
H00047  
Gallbladder cancer
H00458  
Craniosynostosis
H00523  
Noonan syndrome and related disorders
H01557  
Hepatic angiosarcoma
H01592  
Medullary thyroid cancer
H01666  
Angiosarcoma
H01738  
Noonan syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    3845 (KRAS)
   04015 Rap1 signaling pathway
    3845 (KRAS)
   04010 MAPK signaling pathway
    3845 (KRAS)
   04012 ErbB signaling pathway
    3845 (KRAS)
   04370 VEGF signaling pathway
    3845 (KRAS)
   04371 Apelin signaling pathway
    3845 (KRAS)
   04068 FoxO signaling pathway
    3845 (KRAS)
   04072 Phospholipase D signaling pathway
    3845 (KRAS)
   04071 Sphingolipid signaling pathway
    3845 (KRAS)
   04151 PI3K-Akt signaling pathway
    3845 (KRAS)
   04150 mTOR signaling pathway
    3845 (KRAS)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    3845 (KRAS)
   04137 Mitophagy - animal
    3845 (KRAS)
  Cell growth and death
   04210 Apoptosis
    3845 (KRAS)
   04218 Cellular senescence
    3845 (KRAS)
  Cellular community - eukaryotes
   04540 Gap junction
    3845 (KRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    3845 (KRAS)
  Cell motility
   04810 Regulation of actin cytoskeleton
    3845 (KRAS)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    3845 (KRAS)
   04660 T cell receptor signaling pathway
    3845 (KRAS)
   04662 B cell receptor signaling pathway
    3845 (KRAS)
   04664 Fc epsilon RI signaling pathway
    3845 (KRAS)
   04062 Chemokine signaling pathway
    3845 (KRAS)
  Endocrine system
   04910 Insulin signaling pathway
    3845 (KRAS)
   04912 GnRH signaling pathway
    3845 (KRAS)
   04915 Estrogen signaling pathway
    3845 (KRAS)
   04914 Progesterone-mediated oocyte maturation
    3845 (KRAS)
   04917 Prolactin signaling pathway
    3845 (KRAS)
   04921 Oxytocin signaling pathway
    3845 (KRAS)
   04926 Relaxin signaling pathway
    3845 (KRAS)
   04919 Thyroid hormone signaling pathway
    3845 (KRAS)
   04916 Melanogenesis
    3845 (KRAS)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    3845 (KRAS)
  Nervous system
   04725 Cholinergic synapse
    3845 (KRAS)
   04726 Serotonergic synapse
    3845 (KRAS)
   04720 Long-term potentiation
    3845 (KRAS)
   04730 Long-term depression
    3845 (KRAS)
   04722 Neurotrophin signaling pathway
    3845 (KRAS)
  Development
   04360 Axon guidance
    3845 (KRAS)
  Aging
   04211 Longevity regulating pathway - mammal
    3845 (KRAS)
   04213 Longevity regulating pathway - multiple species
    3845 (KRAS)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    3845 (KRAS)
   05230 Central carbon metabolism in cancer
    3845 (KRAS)
   05231 Choline metabolism in cancer
    3845 (KRAS)
   05206 MicroRNAs in cancer
    3845 (KRAS)
   05205 Proteoglycans in cancer
    3845 (KRAS)
   05203 Viral carcinogenesis
    3845 (KRAS)
   05210 Colorectal cancer
    3845 (KRAS)
   05212 Pancreatic cancer
    3845 (KRAS)
   05225 Hepatocellular carcinoma
    3845 (KRAS)
   05214 Glioma
    3845 (KRAS)
   05216 Thyroid cancer
    3845 (KRAS)
   05221 Acute myeloid leukemia
    3845 (KRAS)
   05220 Chronic myeloid leukemia
    3845 (KRAS)
   05218 Melanoma
    3845 (KRAS)
   05211 Renal cell carcinoma
    3845 (KRAS)
   05219 Bladder cancer
    3845 (KRAS)
   05215 Prostate cancer
    3845 (KRAS)
   05213 Endometrial cancer
    3845 (KRAS)
   05224 Breast cancer
    3845 (KRAS)
   05223 Non-small cell lung cancer
    3845 (KRAS)
  Substance dependence
   05034 Alcoholism
    3845 (KRAS)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    3845 (KRAS)
  Infectious diseases
   05166 HTLV-I infection
    3845 (KRAS)
   05161 Hepatitis B
    3845 (KRAS)
   05160 Hepatitis C
    3845 (KRAS)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    3845 (KRAS)
   05165 Human papillomavirus infection
    3845 (KRAS)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    3845 (KRAS)
   01522 Endocrine resistance
    3845 (KRAS)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    3845 (KRAS)
GTP-binding proteins [BR:hsa04031]
 Small (Monomeric) G-proteins
  Ras Family
   Ras [OT]
    3845 (KRAS)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
P01116(Tbio)
UniProt: 
Structure
PDB: 

Jmol
Position
12p12.1
AA seq 189 aa AA seqDB search
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
NT seq 570 nt NT seq  +upstreamnt  +downstreamnt
atgactgaatataaacttgtggtagttggagctggtggcgtaggcaagagtgccttgacg
atacagctaattcagaatcattttgtggacgaatatgatccaacaatagaggattcctac
aggaagcaagtagtaattgatggagaaacctgtctcttggatattctcgacacagcaggt
caagaggagtacagtgcaatgagggaccagtacatgaggactggggagggctttctttgt
gtatttgccataaataatactaaatcatttgaagatattcaccattatagagaacaaatt
aaaagagttaaggactctgaagatgtacctatggtcctagtaggaaataaatgtgatttg
ccttctagaacagtagacacaaaacaggctcaggacttagcaagaagttatggaattcct
tttattgaaacatcagcaaagacaagacagagagtggaggatgctttttatacattggtg
agggagatccgacaatacagattgaaaaaaatcagcaaagaagaaaagactcctggctgt
gtgaaaattaaaaaatgcattataatgtaa

KEGG   Homo sapiens (human): 4893Help
Entry
4893              CDS       T01001                                 

Gene name
NRAS, ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6
Definition
(RefSeq) NRAS proto-oncogene, GTPase
  KO
K07828  
GTPase NRas
Organism
hsa  Homo sapiens (human)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Mitophagy - animal
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Longevity regulating pathway
Longevity regulating pathway - multiple species
Cellular senescence
Axon guidance
VEGF signaling pathway
Apelin signaling pathway
Gap junction
Signaling pathways regulating pluripotency of stem cells
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Relaxin signaling pathway
AGE-RAGE signaling pathway in diabetic complications
Alcoholism
Hepatitis C
Hepatitis B
Human papillomavirus infection
HTLV-I infection
Kaposi's sarcoma-associated herpesvirus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Central carbon metabolism in cancer
Choline metabolism in cancer
Disease
H00003  
Acute myeloid leukemia (AML)
H00010  
Multiple myeloma
H00016  
Oral cancer
H00032  
Thyroid cancer
H00033  
Adrenal carcinoma
H00038  
Malignant melanoma
H00108  
Autoimmune lymphoproliferative syndromes (ALPS)
H00523  
Noonan syndrome and related disorders
H01481  
Myelodysplastic syndrome
H01666  
Angiosarcoma
H01738  
Noonan syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    4893 (NRAS)
   04015 Rap1 signaling pathway
    4893 (NRAS)
   04010 MAPK signaling pathway
    4893 (NRAS)
   04012 ErbB signaling pathway
    4893 (NRAS)
   04370 VEGF signaling pathway
    4893 (NRAS)
   04371 Apelin signaling pathway
    4893 (NRAS)
   04068 FoxO signaling pathway
    4893 (NRAS)
   04072 Phospholipase D signaling pathway
    4893 (NRAS)
   04071 Sphingolipid signaling pathway
    4893 (NRAS)
   04151 PI3K-Akt signaling pathway
    4893 (NRAS)
   04150 mTOR signaling pathway
    4893 (NRAS)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    4893 (NRAS)
   04137 Mitophagy - animal
    4893 (NRAS)
  Cell growth and death
   04210 Apoptosis
    4893 (NRAS)
   04218 Cellular senescence
    4893 (NRAS)
  Cellular community - eukaryotes
   04540 Gap junction
    4893 (NRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    4893 (NRAS)
  Cell motility
   04810 Regulation of actin cytoskeleton
    4893 (NRAS)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    4893 (NRAS)
   04660 T cell receptor signaling pathway
    4893 (NRAS)
   04662 B cell receptor signaling pathway
    4893 (NRAS)
   04664 Fc epsilon RI signaling pathway
    4893 (NRAS)
   04062 Chemokine signaling pathway
    4893 (NRAS)
  Endocrine system
   04910 Insulin signaling pathway
    4893 (NRAS)
   04912 GnRH signaling pathway
    4893 (NRAS)
   04915 Estrogen signaling pathway
    4893 (NRAS)
   04917 Prolactin signaling pathway
    4893 (NRAS)
   04921 Oxytocin signaling pathway
    4893 (NRAS)
   04926 Relaxin signaling pathway
    4893 (NRAS)
   04919 Thyroid hormone signaling pathway
    4893 (NRAS)
   04916 Melanogenesis
    4893 (NRAS)
  Nervous system
   04725 Cholinergic synapse
    4893 (NRAS)
   04726 Serotonergic synapse
    4893 (NRAS)
   04720 Long-term potentiation
    4893 (NRAS)
   04730 Long-term depression
    4893 (NRAS)
   04722 Neurotrophin signaling pathway
    4893 (NRAS)
  Development
   04360 Axon guidance
    4893 (NRAS)
  Aging
   04211 Longevity regulating pathway - mammal
    4893 (NRAS)
   04213 Longevity regulating pathway - multiple species
    4893 (NRAS)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    4893 (NRAS)
   05230 Central carbon metabolism in cancer
    4893 (NRAS)
   05231 Choline metabolism in cancer
    4893 (NRAS)
   05206 MicroRNAs in cancer
    4893 (NRAS)
   05205 Proteoglycans in cancer
    4893 (NRAS)
   05203 Viral carcinogenesis
    4893 (NRAS)
   05225 Hepatocellular carcinoma
    4893 (NRAS)
   05214 Glioma
    4893 (NRAS)
   05216 Thyroid cancer
    4893 (NRAS)
   05221 Acute myeloid leukemia
    4893 (NRAS)
   05220 Chronic myeloid leukemia
    4893 (NRAS)
   05218 Melanoma
    4893 (NRAS)
   05211 Renal cell carcinoma
    4893 (NRAS)
   05219 Bladder cancer
    4893 (NRAS)
   05215 Prostate cancer
    4893 (NRAS)
   05213 Endometrial cancer
    4893 (NRAS)
   05224 Breast cancer
    4893 (NRAS)
   05223 Non-small cell lung cancer
    4893 (NRAS)
  Substance dependence
   05034 Alcoholism
    4893 (NRAS)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    4893 (NRAS)
  Infectious diseases
   05166 HTLV-I infection
    4893 (NRAS)
   05161 Hepatitis B
    4893 (NRAS)
   05160 Hepatitis C
    4893 (NRAS)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    4893 (NRAS)
   05165 Human papillomavirus infection
    4893 (NRAS)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    4893 (NRAS)
   01522 Endocrine resistance
    4893 (NRAS)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    4893 (NRAS)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   4893 (NRAS)
  Exosomal proteins of other body fluids (saliva and urine)
   4893 (NRAS)
  Exosomal proteins of breast cancer cells
   4893 (NRAS)
  Exosomal proteins of colorectal cancer cells
   4893 (NRAS)
GTP-binding proteins [BR:hsa04031]
 Small (Monomeric) G-proteins
  Ras Family
   Ras [OT]
    4893 (NRAS)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
P01111(Tchem)
UniProt: 
Structure
PDB: 

Jmol
Position
1p13.2
AA seq 189 aa AA seqDB search
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDL
PTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQG
CMGLPCVVM
NT seq 570 nt NT seq  +upstreamnt  +downstreamnt
atgactgagtacaaactggtggtggttggagcaggtggtgttgggaaaagcgcactgaca
atccagctaatccagaaccactttgtagatgaatatgatcccaccatagaggattcttac
agaaaacaagtggttatagatggtgaaacctgtttgttggacatactggatacagctgga
caagaagagtacagtgccatgagagaccaatacatgaggacaggcgaaggcttcctctgt
gtatttgccatcaataatagcaagtcatttgcggatattaacctctacagggagcagatt
aagcgagtaaaagactcggatgatgtacctatggtgctagtgggaaacaagtgtgatttg
ccaacaaggacagttgatacaaaacaagcccacgaactggccaagagttacgggattcca
ttcattgaaacctcagccaagaccagacagggtgttgaagatgctttttacacactggta
agagaaatacgccagtaccgaatgaaaaaactcaacagcagtgatgatgggactcagggt
tgtatgggattgccatgtgtggtgatgtaa

KEGG   Homo sapiens (human): 6237Help
Entry
6237              CDS       T01001                                 

Gene name
RRAS, R-Ras
Definition
(RefSeq) RAS related
  KO
K07829  
Ras-related protein R-Ras
Organism
hsa  Homo sapiens (human)
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Phospholipase D signaling pathway
Mitophagy - animal
Autophagy - animal
Cellular senescence
Axon guidance
Apelin signaling pathway
Regulation of actin cytoskeleton
HTLV-I infection
Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    6237 (RRAS)
   04015 Rap1 signaling pathway
    6237 (RRAS)
   04010 MAPK signaling pathway
    6237 (RRAS)
   04371 Apelin signaling pathway
    6237 (RRAS)
   04072 Phospholipase D signaling pathway
    6237 (RRAS)
   04024 cAMP signaling pathway
    6237 (RRAS)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    6237 (RRAS)
   04137 Mitophagy - animal
    6237 (RRAS)
  Cell growth and death
   04218 Cellular senescence
    6237 (RRAS)
  Cell motility
   04810 Regulation of actin cytoskeleton
    6237 (RRAS)
 Organismal Systems
  Development
   04360 Axon guidance
    6237 (RRAS)
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    6237 (RRAS)
  Infectious diseases
   05166 HTLV-I infection
    6237 (RRAS)
GTP-binding proteins [BR:hsa04031]
 Small (Monomeric) G-proteins
  Ras Family
   Ras [OT]
    6237 (RRAS)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
P10301(Tbio)
UniProt: 
Structure
PDB: 

Jmol
Position
19q13.33
AA seq 218 aa AA seqDB search
MSSGAASGTGRGRPRGGGPGPGDPPPSETHKLVVVGGGGVGKSALTIQFIQSYFVSDYDP
TIEDSYTKICSVDGIPARLDILDTAGQEEFGAMREQYMRAGHGFLLVFAINDRQSFNEVG
KLFTQILRVKDRDDFPVVLVGNKADLESQRQVPRSEASAFGASHHVAYFEASAKLRLNVD
EAFEQLVRAVRKYQEQELPPSPPSAPRKKGGGCPCVLL
NT seq 657 nt NT seq  +upstreamnt  +downstreamnt
atgagcagcggggcggcgtccgggacagggcgggggcggccccggggcgggggacctggg
cccggggaccccccgcccagcgagacacacaagctggtggtcgtgggcggcggcggcgtg
ggcaagagcgcgctgaccatccagttcatccagtcctacttcgtgtctgactacgacccc
actattgaggactcctacacgaagatctgcagtgtggatggcatcccagcccggctggac
atcctggacaccgcgggccaggaagagttcggggccatgagagagcagtacatgcgtgct
ggccacggcttcctgctggtgttcgccattaacgaccggcagagtttcaacgaggtgggc
aagctcttcacgcagattctgcgggtcaaggaccgcgacgacttccccgttgtgttggtc
gggaacaaggcagatctggagtcacagcgccaggtcccccgatcagaagcctctgccttc
ggcgcctcccaccacgtggcctactttgaggcctcggccaaactgcgtctcaacgtggac
gaggcttttgagcagctggtgcgggctgtccggaaataccaggaacaagagctcccaccg
agccctcccagtgcccccaggaagaagggcgggggctgcccctgcgtcctcctgtag

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