KEGG   Homo sapiens (human): 22894Help
Entry
22894             CDS       T01001                                 

Gene name
DIS3, 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p
Definition
(RefSeq) DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
  KO
K12585  
exosome complex exonuclease DIS3/RRP44 [EC:3.1.13.-]
Organism
hsa  Homo sapiens (human)
Pathway
RNA degradation
Module
Exosome, eukaryotes
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Genetic Information Processing
  Folding, sorting and degradation
   03018 RNA degradation
    22894 (DIS3)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.13  Exoribonucleases producing 5'-phosphomonoesters
    3.1.13.-  
     22894 (DIS3)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic Type
  mRNA degradation factors
   3'-5' decay
    Exosome cofactors
     22894 (DIS3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
UniProt: 
Position
13q22.1
AA seq 958 aa AA seqDB search
MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVC
PQPHYLLPDTNVLLHQIDVLEDPAIRNVIVLQTVLQEVRNRSAPVYKRIRDVTNNQEKHF
YTFTNEHHRETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRN
KEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQG
IKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKS
QWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGML
SKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNL
GDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDP
PGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMV
PELLSSNLCSLKCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSA
NMNDDITTSLRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETN
SMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAARSRNLEIKTDTAKS
LAESLDQAESPTFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIR
RYADVIVHRLLAVAIGADCTYPELTDKHKLADICKNLNFRHKMAQYAQRASVAFHTQLFF
KSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPNPQLIYDDEIPSLKIEDTV
FHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISIPTDTSNMDLNGPKKKKMKLGK
NT seq 2877 nt NT seq  +upstreamnt  +downstreamnt
atgctcaagtccaagacgttcttaaaaaagacccgggcgggcggcgtgatgaagatcgtg
cgcgagcactacctgcgagacgacatcggctgcggtgcgcccgggtgcgcagcgtgtgga
ggggcgcacgaggggccggccctggagccgcagccccaggacccggcgagcagcgtctgc
ccgcaaccgcactacttgctgcccgacactaatgtgttactgcaccagattgatgttctt
gaggaccctgccatcaggaatgtaattgtgctacaaacagttcttcaagaagtgagaaat
cgcagtgcccccgtatataaacgcatccgagatgtgactaataaccaagagaagcatttc
tatactttcactaatgagcaccatagagaaacctatgtagaacaagaacagggagaaaat
gctaatgacaggaatgatagagcgattcgagtagcagcaaaatggtacaatgaacatttg
aaaaaaatgtcagcagacaaccagctgcaagttatcttcataacaaatgacaggagaaac
aaagagaaagccatagaagaaggaataccagctttcacttgtgaagaatatgtaaagagc
ctaactgctaaccccgaactcatagatcgtcttgcttgtttgtctgaagaagggaatgaa
atagaaagtggaaaaataatattttcagagcatcttcccttaagtaagctacagcaaggc
ataaaatctggtacataccttcaaggaacatttagagctagcagggaaaattacttggaa
gctacagtatggattcatggcgacaatgaagaaaataaagagataatcttacagggactt
aaacatttaaacagagctgttcacgaagatattgtggctgtggagcttctccccaagagt
cagtgggtagcaccatcttctgtggttttacatgatgaaggtcaaaatgaagaagatgtg
gagaaagaagaagagacagaacgaatgcttaagactgctgtaagcgagaaaatgttgaag
cctacaggtagagttgtaggaataataaaaaggaattggagaccatattgtggcatgctt
tccaagtctgacattaaggagtcaagaagacatctctttacacctgctgataagagaatc
cctcgaattcgcatagaaaccagacaggcttccacattagaaggacggagaattattgtt
gctattgatggttggcccagaaattccagatatccaaatggacactttgtgagaaattta
ggtgatgttggagagaaagagactgaaacagaagttttgttacttgaacacgatgttccc
catcagcctttttcacaggctgttcttagttttctgccaaagatgccctggagcattact
gaaaaggacatgaaaaaccgagaagacctgaggcatctgtgtatttgtagtgtagaccca
ccaggatgtactgatatagacgatgctctacattgtcgagaactcgaaaatggaaatttg
gaggttggtgttcatattgctgatgtgagccattttattaggccaggaaatgccttggat
caagaatcagccagaagaggaacaactgtgtatctttgtgaaaagaggattgacatggtt
ccagagttgcttagctctaacttgtgttccttaaaatgtgacgtggacaggctggcattt
tcatgtatttgggaaatgaatcacaatgctgaaatcttaaaaacgaagtttaccaaaagt
gttattaattcaaaggcatctctgacgtatgctgaagctcagttgagaattgattcagca
aacatgaatgatgatattaccactagtctccgtggactgaataaactagccaaaattctg
aagaaaagaaggattgaaaaaggggctttgactctatcctctcctgaagttcgattccac
atggacagtgaaactcacgatcctatagatctgcagaccaaggaacttagggaaacaaat
tccatggttgaagaatttatgttacttgccaatatttctgttgcaaaaaaaattcatgag
gaattttctgaacatgctctgcttcgaaaacatcctgctccacctccatcaaattatgaa
attcttgttaaggcagccaggtcaaggaatttggaaattaagactgatacagccaagtct
ttggctgagtctttggatcaggccgaatctcctacttttccatatctaaacactctgttg
agaatattagccactcgctgtatgatgcaagctgtgtacttctgttctggaatggataat
gattttcatcactatggcttagcgtctccaatatacacacattttacttcacccattaga
agatacgcagatgtcattgttcatcggcttttggctgtggctattggggctgactgtact
tatccagagttgacagacaaacacaagcttgcagatatatgtaaaaatctaaatttccgg
cacaaaatggctcaatatgcccaacgtgcatcagtggcttttcatacccagttattcttc
aaaagcaaaggaatagtaagtgaagaagcctatattttatttgtaagaaagaatgccatt
gtggtattaattccaaagtatggtttagaagggacagtcttttttgaagaaaaggacaaa
ccaaacccacagcttatttatgatgatgagataccctcacttaaaatagaagatacagtg
ttccatgtatttgataaagttaaagtgaaaatcatgttagactcatctaatcttcaacat
cagaagatccgaatgtccctggtagaaccacagataccaggaataagcattcctactgat
acttcaaacatggaccttaatggaccaaagaaaaagaagatgaagcttggaaaatag

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