KEGG T01001: 23020

Homo sapiens (human): 23020

Entry

23020 CDS T01001

Gene name

SNRNP200, ASCC3L1, BRR2, HELIC2, RP33, U5-200KD

Definition

small nuclear ribonucleoprotein 200kDa (U5) (EC:3.6.4.13)

Orthology

K12854

pre-mRNA-splicing helicase BRR2 [EC:3.6.4.13]

Organism

hsa Homo sapiens (human)

Pathway

hsa03040

Spliceosome

Module

hsa_M00355

Spliceosome, 35S U5-snRNP

Disease

H00527

Retinitis pigmentosa (RP)

Class

Genetic Information Processing; Transcription; Spliceosome [PATH:hsa03040]

SSDB

Motif

Pfam:

Sec63 DEAD ResIII Helicase_C AAA_22 PhoH

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

2Q0Z 4F92 4F91 4F93

Position

2q11.2

AA seq 2136 aa
MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLVGKLEGTRMGDKAQRTK
PQMQEERRAKRRKRDEDRHDINKMKGYTLLSEGIDEMVGIIYKPKTKETRETYEVLLSFI
QAALGDQPRDILCGAADEVLAVLKNEKLRDKERRKEIDLLLGQTDDTRYHVLVNLGKKIT
DYGGDKEIQNMDDNIDETYGVNVQFESDEEEGDEDVYGEVREEASDDDMEGDEAVVRCTL
SANLVASGELMSSKKKDLHPRDIDAFWLQRQLSRFYDDAIVSQKKADEVLEILKTASDDR
ECENQLVLLLGFNTFDFIKVLRQHRMMILYCTLLASAQSEAEKERIMGKMEADPELSKFL
YQLHETEKEDLIREERSRRERVRQSRMDTDLETMDLDQGGEALAPRQVLDLEDLVFTQGS
HFMANKRCQLPDGSFRRQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKT
LNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIY
IAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKG
GERTYTQLVRLIILDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYED
VATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQ
VLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPY
GFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGR
WTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDM
LNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTA
ALMLDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSL
SSEFKNITVREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMAD
MVYVTQSAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVV
KKIEKKNFPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKV
ELTITPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFE
PLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESL
YQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQSSEGRCVYIT
PMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWK
QRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDV
AHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITKHSPKKPVI
VFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYL
HEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQYYNGKIHAYVDYP
IYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEI
VTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSK
CISIEDEMDVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPI
RHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAI
RLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSKDSYLKQLPHFTSEHIKRCTDKGVE
SVFDIMEMEDEERNALLQLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQ
LEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATG
AHNYTLYFMSDAYMGCDQEYKFSVDVKEAETDSDSD

NT seq 6411 nt +upstreamnt +downstreamnt
atggcggatgtaaccgcccgtagtctgcaatacgagtacaaggcgaactcgaatcttgtg
ctccaagctgaccgttctctcattgaccggacccgccgggatgaacccacaggagaggtg
ctgtcccttgttgggaagctggagggcacccgtatgggagacaaggctcaacggaccaaa
ccgcagatgcaggaggaaagaagagccaagcgaagaaagcgtgatgaggaccggcatgac
atcaacaagatgaagggttatactctgctgtcggagggcattgatgagatggtgggcatc
atctacaagcccaaaactaaagagactcgggagacctatgaggtgctactcagcttcatc
caggctgctcttggggaccagccacgtgatatcctttgtggggcagctgatgaagttcta
gctgttctaaagaatgaaaagctgcgggacaaggaaaggcgaaaggagattgacctgctg
ctgggtcaaacagatgataccagataccatgtgctagtgaacctgggcaaaaagatcaca
gactatggtggagataaggaaatccaaaatatggatgacaacattgatgagacatacggt
gtgaatgtgcagtttgagtctgatgaggaggaaggtgatgaagacgtatacggggaggtt
cgagaagaggcatctgatgatgacatggaaggggacgaggctgtcgtgcgctgcaccctc
tcggctaatctcgtagcctcaggtgaactgatgagttccaagaagaaggatttgcaccct
cgggatattgatgcattttggctgcagcggcagctcagtcgtttctatgatgatgccatc
gtgtcgcagaagaaggcagatgaagtattggagattttgaagacggccagtgatgatcgg
gaatgtgaaaatcagctggttctgctgcttggtttcaacacctttgatttcattaaagtg
ttgcggcagcacaggatgatgattttatactgtaccttgctggccagtgcacaaagtgaa
gctgaaaaggaaaggattatgggaaagatggaagctgacccagagctatccaagttcctc
taccagcttcatgaaaccgagaaggaggatctgatccgagaggaaaggtcccggagagag
cgagtgcgtcagtctcgaatggacacagatctggaaaccatggatctcgaccagggtgga
gaggcactggctccacggcaggttctggacttggaggacctggtttttacccaagggagc
cactttatggccaataaacgctgtcagcttcctgatggatccttccgtcgccagcgtaag
ggctatgaagaggtgcatgtgcctgctctgaagcccaagccctttggctcagaagaacaa
ctgcttccagtggaaaagctgccaaagtatgcccaggctgggtttgagggcttcaaaaca
ctgaatcggatccagagtaagctctaccgtgctgcccttgagacggatgagaatctgctg
ctgtgtgctcctactggtgctgggaagaccaacgtggccctgatgtgcatgctccgagag
attgggaaacacataaacatggacggcaccatcaatgtggatgacttcaagattatctac
attgcccccatgcgctccttggtgcaggagatggtgggcagctttggaaagcgcctggcc
acttatggcatcactgttgctgaactgactggggaccaccagctgtgcaaagaagagatc
agtgccactcagatcatcgtctgcacccccgagaagtgggacatcatcacccgcaagggt
ggtgagcgcacctacacccagctggtgcggctcatcattctggatgagattcatcttctc
cacgatgacagaggtcctgtcttagaagctttagtggccagggccatccgaaacattgag
atgacccaagaggatgtccgactcattggtctcagtgccaccctacccaactatgaagat
gtagccacctttctacgtgttgaccctgccaagggtctcttttactttgacaacagcttc
cgtccagtgcctctggaacagacatatgtgggtatcacagagaaaaaagctatcaagcgt
ttccagatcatgaatgaaatcgtctatgaaaaaatcatggaacatgctggaaaaaatcag
gtgctggtgtttgtccactcccggaaggagactggaaagacagccagggccatccgggac
atgtgcctagaaaaggacactctgggtctgtttctgagggagggctcagcctccacagaa
gtcctgcgaacagaagctgagcagtgcaagaacctagagctgaaggatcttctgccttat
ggctttgctattcatcacgcaggcatgaccagggttgaccgaacactcgtggaggatctt
tttgctgataaacatattcaggttttagtttccacagcaactctagcttggggtgtgaat
ctccctgcacatacagtcatcatcaaaggcacccaggtgtacagtccagagaaggggcgt
tggacagaactgggagcactggacattctgcagatgctgggacgtgccggaagaccccag
tatgacaccaagggtgaaggcatactcatcacatctcatggggagctacagtactacctg
tccctcctcaatcaacaacttcctattgaaagccagatggtttcaaagcttcctgacatg
ctcaatgcagaaatcgtgctaggaaatgtccagaatgccaaggatgcggtgaactggctg
ggctatgcctacctctatatccgaatgctgcgatccccaaccctctatggcatctctcat
gatgacctcaagggagatcccctgctggaccagcgccgactagatctggttcatacagct
gccctgatgctggacaagaacaatctggtcaagtacgacaagaagacgggcaacttccag
gtgacagaactgggccgtatagccagccactactacatcaccaatgatacagtgcagact
tacaaccagctgctgaagcccaccctgagtgagattgagcttttcagggtcttctcattg
tcctctgagttcaagaacatcacagtgagagaggaggagaagctggagctgcagaagttg
ctggagagggtgcctatccctgtaaaggagagcattgaggaacccagtgctaagatcaac
gttcttctgcaagccttcatctcacagctgaaattggagggctttgcactgatggctgac
atggtgtatgtcacacagtcggctggccggttgatgcgagcgatatttgaaattgtcctg
aaccgaggttgggcacagcttacagacaagaccctgaacctctgcaagatgatcgacaaa
cgcatgtggcagtccatgtgtcctctgcgccagttccggaaactccctgaggaagtagtg
aagaagattgagaagaagaatttcccctttgagcgtctgtacgacctgaatcataatgag
attggggagcttatccgcatgccaaagatggggaagaccatccacaaatatgtccatctg
tttcccaagttggagttgtcagtgcacctgcagcctatcacacgctccaccctgaaggtg
gagctgaccatcacgccagacttccagtgggatgaaaaggtgcatggttcatccgaggct
ttttggattctggtggaggatgtggacagcgaggtgattctgcaccatgagtattttctc
ctcaaggccaagtacgcccaggacgagcacctcattacattcttcgtgcctgtctttgaa
ccgctgccccctcagtacttcatccgagtggtgtctgaccgctggctctcttgtgagacc
cagctgcctgtctccttccggcacctgatcttgccggagaagtacccccctccaaccgaa
cttttggacctgcagcccttgcccgtgtctgctctgagaaacagtgcctttgagagtctt
taccaagataaatttcctttcttcaatcccatccagacccaggtgtttaacactgtatac
aacagtgacgacaacgtgtttgtgggggcccccacgggcagcgggaagactatttgtgca
gagtttgccatcctgcgaatgctgctgcagagctcggaggggcgctgtgtgtacatcacc
cccatggaggccctggcagagcaggtatacatggactggtacgagaagttccaggacagg
ctcaacaagaaggtggtactcctgacaggcgagaccagcacagacctgaagctgctgggc
aaagggaacattatcatcagcacccctgagaagtgggacatactttcccggcgatggaag
cagcgcaagaacgtgcagaacatcaacctcttcgtggtggatgaggtccaccttatcggg
ggcgagaatgggcctgtcttagaagtgatctgctcccgaatgcgctacatctcctcccag
attgagcggcccattcgcattgtggcactcagctcttcgctctccaatgccaaggatgtg
gcccactggctgggctgcagtgccacctccaccttcaacttccatcccaatgtgcgtccc
gtccccttggagctgcacatccagggcttcaacatcagccatacacaaacccgcctgctc
tccatggccaagcctgtgtaccatgctatcaccaagcactcgcccaagaagcctgtcatt
gtctttgtgccgtctcgcaagcagacccgcctcactgccattgacatcctcaccacctgt
gcagcagacatccaacggcagaggttcttgcactgcaccgagaaggatctgattccgtac
ctggagaagctaagtgacagcacgctcaaggaaacgctgctaaatggggtgggctacctg
catgaggggctcagccccatggagcgacgcctggtggagcagctcttcagctcaggggct
atccaggtggtggtggcttctcggagtctctgctggggcatgaacgtggctgcccacctg
gtaatcatcatggatacccagtactacaatggcaagatccacgcctatgtggattacccc
atctatgacgtgcttcagatggtgggccacgccaaccgccctttgcaggacgatgagggg
cgctgtgtcatcatgtgtcagggctccaagaaggatttcttcaagaagttcttatatgag
ccattgccagtagaatctcacctggaccactgtatgcatgaccacttcaatgctgagatc
gtcaccaagaccattgagaacaagcaggatgctgtggactacctcacctggacctttctg
taccgccgcatgacacagaaccccaattactacaacctgcagggcatctcccatcgtcac
ttgtcggaccacttgtcagagctggtggagcagaccctgagtgacctggagcagtccaag
tgcatcagcatcgaggacgagatggacgtggcgcctctgaacctaggcatgatcgccgcc
tactattacatcaactacaccaccattgagctcttcagcatgtccctcaatgccaagacc
aaggtgcgagggcttatcgagatcatctccaatgcagcagagtatgagaacattcccatc
cggcaccatgaagacaatctcctgaggcagttggctcagaaggtcccccacaagctgaat
aaccctaagttcaatgatccgcacgtcaagaccaacctgctcctgcaggctcacttgtct
cgcatgcagctgagtgctgagttgcagtcagatacggaggaaatccttagtaaggcaatc
cggctcatccaggcctgcgtggatgtcctttccagcaatgggtggctcagccctgctctg
gcagctatggaactggcccagatggtcacccaagccatgtggtccaaggactcatacctg
aagcagctgccacacttcacctctgagcatatcaaacgttgcacagacaagggagtggag
agtgttttcgacatcatggagatggaggatgaagaacggaacgcgttgcttcagctgact
gacagccagattgcagatgtggctcgcttttgtaaccgctaccctaatatcgaactatct
tatgaggtggtagataaggacagcatccgcagtggcgggccagttgtggtgctggtgcag
ctggagcgagaggaggaagtcacaggccctgtcattgcgcctctcttcccgcagaaacgt
gaagagggctggtgggtggtgattggagatgccaagtccaatagcctcatctccatcaag
aggctgaccttgcagcagaaggccaaggtgaagttggactttgtggccccagccactggt
gcccacaactacactctgtacttcatgagtgacgcttacatgggatgtgaccaggagtac
aaattcagcgtggatgtgaaagaagctgagacagacagtgattcagattga

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (2)   
   KEGG PATHWAY (1)   
   KEGG MODULE (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (16)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (47)   
   RefSeq(nuc) (1)   
   GenBank (23)   
   EMBL (23)   
3D Structure (4)   
   PDB (4)   
Protein domain (6)   
   Pfam (6)   
All databases (91)   

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