KEGG T01001: 25885

Homo sapiens (human): 25885

Entry

25885 CDS T01001

Gene name

POLR1A, A190, RPA1, RPA194, RPO1-4, RPO14

Definition

polymerase (RNA) I polypeptide A, 194kDa (EC:2.7.7.6)

Orthology

K02999

DNA-directed RNA polymerase I subunit RPA1 [EC:2.7.7.6]

Organism

hsa Homo sapiens (human)

Pathway

hsa00230	Purine metabolism
hsa00240	Pyrimidine metabolism
hsa01100	Metabolic pathways
hsa03020	RNA polymerase

Module

hsa_M00182

RNA polymerase I, eukaryotes

Class

Metabolism; Nucleotide metabolism; Purine metabolism [PATH:hsa00230]
Metabolism; Nucleotide metabolism; Pyrimidine metabolism [PATH:hsa00240]
Genetic Information Processing; Transcription; RNA polymerase [PATH:hsa03020]

SSDB

Motif

Pfam:

RNA_pol_Rpb1_5 RNA_pol_Rpb1_2 RNA_pol_Rpb1_3 RNA_pol_Rpb1_4 RNA_pol_Rpb1_1 Daxx

Other DBs

NCBI-GI:

NCBI-GeneID:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Position

2p11.2

AA seq 1720 aa
MLISKNMPWRRLQGISFGMYSAEELKKLSVKSITNPRYLDSLGNPSANGLYDLALGPADS
KEVCSTCVQDFSNCSGHLGHIELPLTVYNPLLFDKLYLLLRGSCLNCHMLTCPRAVIHLL
LCQLRVLEVGALQAVYELERILNRFLEENPDPSASEIREELEQYTTEIVQNNLLGSQGAH
VKNVCESKSKLIALFWKAHMNAKRCPHCKTGRSVVRKEHNSKLTITFPAMVHRTAGQKDS
EPLGIEEAQIGKRGYLTPTSAREHLSALWKNEGFFLNYLFSGMDDDGMESRFNPSVFFLD
FLVVPPSRYRPVSRLGDQMFTNGQTVNLQAVMKDVVLIRKLLALMAQEQKLPEEVATPTT
DEEKDSLIAIDRSFLSTLPGQSLIDKLYNIWIRLQSHVNIVFDSEMDKLMMDKYPGIRQI
LEKKEGLFRKHMMGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQEL
RQAVINGPNVHPGASMVINEDGSRTALSAVDMTQREAVAKQLLTPATGAPKPQGTKIVCR
HVKNGDILLLNRQPTLHRPSIQAHRARILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQ
SELGRAEAYVLACTDQQYLVPKDGQPLAGLIQDHMVSGASMTTRGCFFTREHYMELVYRG
LTDKVGRVKLLSPSILKPFPLWTGKQVVSTLLINIIPEDHIPLNLSGKAKITGKAWVKET
PRSVPGFNPDSMCESQVIIREGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGKVLTC
LARLFTAYLQLYRGFTLGVEDILVKPKADVKRQRIIEESTHCGPQAVRAALNLPEAASYD
EVRGKWQDAHLGKDQRDFNMIDLKFKEEVNHYSNEINKACMPFGLHRQFPENSLQMMVQS
GAKGSTVNTMQISCLLGQIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIK
PPEFFFHCMAGREGLVDTAVKTSRSGYLQRCIIKHLEGLVVQYDLTVRDSDGSVVQFLYG
EDGLDIPKTQFLQPKQFPFLASNYEVIMKSQHLHEVLSRADPKKALHHFRAIKKWQSKHP
NTLLRRGAFLSYSQKIQEAVKALKLESENRNGRSPGTQEMLRMWYELDEESRRKYQKKAA
ACPDPSLSVWRPDIYFASVSETFETKVDDYSQEWAAQTEKSYEKSELSLDRLRTLLQLKW
QRSLCEPGEAVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMVASANIK
TPMMSVPVLNTKKALKRVKSLKKQLTRVCLGEVLQKIDVQESFCMEEKQNKFQVYQLRFQ
FLPHAYYQQEKCLRPEDILRFMETRFFKLLMESIKKKNNKASAFRNVNTRRATQRDLDNA
GELGRSRGEQEGDEEEEGHIVDAEAEEGDADASDAKRKEKQEEEVDYESEEEEEREGEEN
DDEDMQEERNPHREGARKTQEQDEEVGLGTEEDPSLPALLTQPRKPTHSQEPQGPEAMER
RVQAVREIHPFIDDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKGIT
RCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRV
IEKEIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGIRSNSSPLQQMTFETSFQF
LKQATMLGSHDELRSPSACLVVGKVVRGGTGLFELKQPLR

NT seq 5163 nt +upstreamnt +downstreamnt
atgttgatctccaagaacatgccctggcggcggctgcagggcatttccttcgggatgtat
tcggctgaagagctcaagaaattaagtgttaaatccattacgaaccctcgatacctggac
agcctggggaacccatcggcaaacggcctgtacgatttagctttgggccctgcagattcc
aaagaggtgtgctccacctgcgtgcaggacttcagcaactgttctgggcacctgggccac
attgagctcccactcacagtgtataaccctctcctcttcgataagctgtacctgctgctt
cggggctcttgtttaaactgccacatgctgacttgtccccgggccgtgattcacctctta
ctctgccagctgagggttctggaagtcggggccctacaagcagtctacgagcttgagaga
attctgaacaggtttctggaagaaaatcccgatccctctgcctctgaaattcgggaggaa
ttagaacaatacacaactgaaattgtgcagaacaacctcctggggtcccagggcgcacat
gtaaagaacgtgtgtgagagcaagagcaagctcattgctctcttctggaaggcacatatg
aatgctaagcgctgtccccactgcaagaccgggcgatccgttgtccgaaaggaacacaac
agcaagttgactatcacgtttccagccatggtgcacaggacagctggccagaaggactct
gagcccctgggaattgaggaagctcagataggaaaacgaggatacttaacacccaccagt
gcccgcgaacacctttctgccctgtggaagaatgaaggattctttctgaactaccttttt
tcgggaatggatgatgatggtatggaatccagattcaatcccagtgtgttctttctagat
ttcttggtggtgccgccctcaaggtatcgcccagtcagtcgcctaggagaccagatgttt
actaatggccagacggtgaacttgcaggctgtcatgaaggatgtagttctgattcgaaaa
cttctggcattgatggcccaagaacagaagttgccagaggaagtggccacacccactaca
gatgaggaaaaagactctttgattgctattgaccgatcctttttgagtacacttccaggc
cagtccctcatagacaaactttacaacatttggattcgccttcagagccacgtcaatatt
gtgtttgatagcgagatggacaaactaatgatggacaagtacccaggcattaggcagatc
ctggagaagaaagaaggcctgttccgaaaacacatgatgggaaagcgagtggactacgct
gcgcgctcagtcatctgcccagacatgtacatcaacaccaacgaaattggaattcccatg
gtgtttgccacaaaactgacctacccacagccagttaccccatggaatgttcaggaactt
aggcaagcggtcatcaacggccctaatgtgcacccaggagcctccatggtcatcaatgag
gacggcagccgcacagccctgagcgctgtggacatgacccagcgagaggccgtggccaag
cagcttctgaccccagccacgggggcacctaagccccaggggacaaaaattgtgtgccgg
catgtgaagaatggggacattctgctactgaaccgacagcccacactgcacagaccctcc
atccaggcccaccgtgcccgcatcctgcctgaagagaaagtgctgcggctccactatgcc
aactgcaaggcctataatgccgactttgatggagacgagatgaatgcccatttcccccag
agtgagctgggccgggccgaggcctacgtcctggcctgcactgatcagcagtaccttgtt
cccaaggatggccaaccattggcgggactgatccaggatcacatggtttcaggggcaagc
atgactactcggggttgctttttcacccgggagcactatatggagctggtgtaccgagga
ctcacggacaaagtggggcgcgtgaagctcctttctccttccatcctgaagccctttccg
ctgtggacaggaaaacaggttgtgtcaacgctgctcataaatataatcccagaggaccac
atcccactgaacttatctggaaaggcgaaaatcactgggaaagcctgggtgaaggaaact
cctcgatccgttcctggctttaaccctgactcgatgtgcgagtcccaggtgatcatcagg
gaaggggagctgctctgcggagtgctggacaaggcgcactatgggagctccgcctacggc
ctggtccactgctgctatgagatctatggaggcgagaccagcggcaaggttctaacctgc
ctggcccgcctcttcaccgcctacctgcagctctacagaggcttcaccttgggcgtggaa
gacattttggtgaagccaaaggcagatgtcaagaggcaacgtatcattgaagaatccacc
cactgcgggccccaggctgtcagggctgcattaaacctgccagaagccgcatcatatgat
gaggtccgaggaaaatggcaggatgcccatctgggcaaggaccagagggattttaacatg
attgatctgaagttcaaggaggaagtgaaccattacagcaatgagattaacaaggcatgc
atgccttttggcctacacagacagttcccagagaacagcctgcagatgatggtgcagtcg
ggagccaaaggttcaactgtgaacacgatgcagatctcgtgcctgctgggccagattgaa
ctggaaggtcggagacccccgctgatggcgtctggcaagtcactgccctgctttgagcct
tatgagttcacccccagggctggtggctttgtcactggcaggttcctcaccggcatcaaa
cctcctgagttcttcttccactgcatggcaggacgagagggcctggtggacactgctgtg
aaaaccagccgctcaggctatctccaaaggtgcatcatcaagcacctagaggggctggtc
gtgcagtatgatctcacggtccgtgacagtgacggcagtgtggtgcagttcctgtatggg
gaggatggcctggacatccccaagacacagttcctgcagcccaagcagttccccttcctg
gccagcaactacgaggtgataatgaaatcacagcatctccatgaagttttatccagagca
gatcccaaaaaagctctccaccacttcagagctatcaaaaaatggcaaagcaagcacccc
aacaccctgctgagaagaggcgccttcttgagttattcccagaaaattcaggaagctgtg
aaagccctgaaacttgagagtgaaaaccgcaatggccgcagccctgggactcaggagatg
ctgaggatgtggtatgagttggatgaggaaagccgaaggaaataccagaagaaggcggcc
gcttgtcctgaccccagtctgtctgtctggcgtcctgacatctactttgcatcagtgtca
gaaacatttgaaacaaaggttgatgactacagtcaagagtgggcagctcaaacagagaag
agttatgagaaatcagagctttctctcgacaggttgaggaccttgctgcagctgaagtgg
cagcgctcactgtgtgagccgggcgaggctgtgggcctgctggctgcccagagcatcgga
gagccctccacccagatgaccctcaacaccttccactttgcaggcagaggcgagatgaac
gtcaccctgggcattccaaggttgcgggagattctcatggtggccagcgccaacatcaag
acacccatgatgagcgtgcccgtgctcaacaccaagaaagccctgaagagagtgaaaagc
ctgaagaagcaactcaccagggtgtgcttgggggaggtgttgcagaaaattgacgtccag
gagtccttctgtatggaagaaaaacagaacaaattccaggtgtaccagctgcggtttcag
ttcctgccacatgcatattaccagcaggagaagtgcctgagacccgaggacatcctgcgc
ttcatggaaacaagattctttaaacttctgatggaatccatcaaaaagaagaataataaa
gcatcagctttcaggaacgtaaacactcgaagagctacacagcgggatctggacaacgct
ggggagttggggaggagtcggggagagcaggagggtgatgaggaagaggaggggcacatt
gtggatgctgaagctgaggagggggacgccgatgcctctgatgccaaacgcaaggagaag
caggaggaggaggttgattatgagagtgaggaagaggaggagagggagggcgaggagaac
gacgatgaagacatgcaggaggaacgaaatccccacagggaaggtgctcgaaagacccaa
gagcaagatgaagaggtgggcttaggcactgaggaggacccgtcccttcccgccctcctg
acgcagccccggaaacccacccacagccaggagccccaggggcccgaggccatggagcgc
cgggtccaggctgtgcgtgagatccacccgttcatagatgactaccagtacgacaccgag
gagagcctgtggtgccaggtgacagtgaagctccctctgatgaagatcaactttgacatg
agctccctggtagtatctttggcccatggtgccgtcatctatgcgaccaagggcatcact
cggtgcctcctgaatgaaacaaccaacaataagaacgagaaggagcttgtgctaaacaca
gaaggaatcaacctcccagagctattcaagtatgcagaggtcctggatctgcgccgcctc
tactccaacgacatccacgccatagccaacacgtatggcattgaggccgcgctgcgggtg
atcgagaaggagatcaaggatgtgtttgccgtgtatggcatcgcggtcgaccctcgccat
ctctccctggttgctgattatatgtgcttcgagggtgtttacaagccactgaatcgcttt
gggatccggtcaaactcttccccgctacagcagatgacatttgaaaccagcttccagttt
ctgaagcaagccaccatgctgggatcccacgatgagctgaggtctccttctgcctgcctt
gtggtcgggaaggtcgtcaggggcgggacaggcctgttcgagctcaagcagcctctgaga
tag

All links

Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (11)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (2)   
   RefSeq(pep) (1)   
DNA sequence (27)   
   RefSeq(nuc) (1)   
   GenBank (13)   
   EMBL (13)   
Protein domain (6)   
   Pfam (6)   
All databases (72)   

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