KEGG T01001: 2889

Homo sapiens (human): 2889

Entry

2889 CDS T01001

Gene name

RAPGEF1, C3G, GRF2

Definition

Rap guanine nucleotide exchange factor (GEF) 1

Orthology

K06277

Rap guanine nucleotide exchange factor (GEF) 1

Organism

hsa Homo sapiens (human)

Pathway

hsa04510	Focal adhesion
hsa04722	Neurotrophin signaling pathway
hsa04910	Insulin signaling pathway
hsa05211	Renal cell carcinoma

Class

Cellular Processes; Cell communication; Focal adhesion [PATH:hsa04510]
Organismal Systems; Endocrine system; Insulin signaling pathway [PATH:hsa04910]
Organismal Systems; Nervous system; Neurotrophin signaling pathway [PATH:hsa04722]
Human Diseases; Cancers; Renal cell carcinoma [PATH:hsa05211]

SSDB

Motif

Pfam:

RasGEF RasGEF_N

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Position

9q34.3

AA seq 1077 aa
MDTDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKEATDRFLPEG
YPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKV
LEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSE
DKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGPAELPLTDRE
VEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSPTRV
AVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGGESPRLSPCSSIGKLSKS
DEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNLSPLPESLGE
SGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRSAASQTADGSGCRVSYER
HPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPVEFVGDFTAPESTGDPEKP
PPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQKNKLLMEVYGFSDSFSGVD
SVQELAPPPALPPKQRQLEPPAGKDGHPRDPSAVSGVPGKDSRDGSERAPKSPDALESAQ
SEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFL
TTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILK
LLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHDFH
SHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ
EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTL
IDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILD
SMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT

NT seq 3234 nt +upstreamnt +downstreamnt
atggacacagactctcagcgttctcatctctcttccttcaccatgaagctgatggacaaa
ttccactcacccaaaatcaagagaacgccatcaaagaagggaaaaccagctgaggtgtcc
gtaaagattccagagaagcctgtgaacaaagaggcaacagacagatttctaccagagggc
taccctctccccttggatctggagcagcaggcagtagaatttatgtccaccagtgctgtg
gcttccaggtctcaaaggcagaagaacctgagctggctggaggagaaagagaaggaagtt
gtcagtgccctgcgctactttaagaccattgtggacaaaatggcaattgataagaaggta
ctggagatgcttccagggtcagccagcaaggtgctggaggccatcttacccctggtgcag
aacgatcctcgaattcagcacagctcagccctctcttcctgctatagccgagtgtaccaa
agcctcgccaacctcattcgctggtctgaccaagtgatgctggaaggcgtgaactcagaa
gacaaggagatggtgacgactgtgaagggggtcatcaaggctgtgctggatggagtgaag
gagctggtcaggctcaccatcgagaagcagggacgtccgtctccgacgagccccgtgaag
cccagttcccctgccagcaagcctgatggcccagcagagctccccctgacagaccgcgag
gtagagatcctaaacaagacgactgggatgtcacagtcaactgagctcctcccagatgcc
acggatgaagaggtcgcgccccccaagcctcctctgcctggcattcgggtggttgataat
agtcctccaccagcattgccacccaagaaaagacagtcggcgccgtcccctacccgagtg
gctgtggtggcccccatgagccgagccaccagtggctccagtttgcctgttggaatcaat
aggcaggattttgatgttgactgttacgcacagaggcgactgtcaggaggcagccactca
tatggtggagagtcgccccgcctctccccctgcagcagcataggcaagctcagcaagtca
gacgagcagctgtcctctctggacagggacagtgggcagtgctcccggaacacaagctgt
gaaacactagaccactatgatcccgactatgaattcctccagcaagacctctctaacgca
gaccagatacctcagcagacggcctggaaccttagcccgttgccagagtctttgggggag
tctgggtctccatttcttggccctcctttccagctgcctcttggcggccatccccagcca
gacggacctctggccccagggcagcagacagatacgccacctgctctccccgagaagaag
cgcaggagcgcagcctcccagacggcggacggctctggctgcagggtgtcctacgagcgg
catccctcgcagtatgacaacatctctggggaggacctgcagagcacagccccgatccca
tccgtcccctacgcgccctttgctgctattctgccctttcagcatggaggttcctcagcc
cctgtcgaatttgtgggtgattttactgctcctgagtcaaccggtgacccagaaaaacca
cctcctctaccagagaagaaaaacaaacacatgctggcctacatgcagttgctggaggac
tactcggagccgcagccctctatgttctaccagacgccacagaacgagcacatctaccag
cagaagaacaagctcctcatggaggtatacggcttcagcgactccttcagtggggtggac
tccgtgcaggagctggccccgccgcccgccctaccccccaagcagcggcagctggagcca
ccggctgggaaagacggacatcccagagatccctcagcggtcagcggcgtccctgggaag
gacagcagagacggcagtgagagggccccaaagtcaccagatgctctggagtcggctcag
tcggaggaggaagtggacgagctgtccctcattgaccacaacgaaattatgtccaggctg
acgctcaagcaggagggtgatgacgggccggacgtccgcggaggatctggggacatctta
ctggtccatgctactgagactgacaggaaagatttggtgttgtactgcgaggcattcctg
accacctacaggaccttcatctccccagaggagctcatcaagaagctgcagtacagatat
gagaaattctctccctttgccgacacattcaagaagcgcgtcagcaagaacacgttcttc
gtgctggtacgggtggtggatgagctctgcctggtggagttgacagaagagatcctgaag
ctgctgatggaactggtcttccgcctggtgtgcaatggggagctgagcctggcccgtgtg
ctccggaagaacatcctggacaaggtggaccagaagaagctactcaggtgtgccacctcc
agccagcccctggcagcccggggggtagcagccaggccggggaccttgcacgactttcac
agccatgagatagcggagcagctaacgctgctggatgctgagctcttctataaaatagag
attcctgaggttttgctttgggcaaaagagcagaatgaggagaagagccccaacttgacc
cagttcacggagcacttcaacaacatgtcctactgggtccggtccataatcatgttacag
gaaaaggcccaggacagggaacggctgctcttgaagttcatcaagatcatgaagcacttg
cggaagctgaataacttcaactcctacttggccatcctctctgccctggactcggcgccc
atccgcaggctggagtggcagaagcagacttcagagggcctggccgagtactgcacactg
atcgacagctcgtcctccttccgagcctaccgggccgccctctcggaggtggaaccgccg
tgcatcccgtacctggggctgatcctgcaggacctgaccttcgttcacctgggaaaccca
gactacatcgacgggaaagtgaacttctccaagcggtggcagcagttcaacatcctcgac
agcatgcgctgcttccagcaggcgcactatgacatgcggaggaacgacgacattataaac
ttcttcaatgacttcagtgaccacctggctgaggaggccctatgggaactgtctctgaaa
attaaacccaggaacataacaaggagaaaaacagaccgggaagagaagacctag

All links

Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (16)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (46)   
   RefSeq(nuc) (2)   
   GenBank (22)   
   EMBL (22)   
Protein domain (2)   
   Pfam (2)   
All databases (81)   

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