KEGG T01001: 3290

Homo sapiens (human): 3290

Entry

3290 CDS T01001

Gene name

HSD11B1, 11-DH, 11-beta-HSD1, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1

Definition

hydroxysteroid (11-beta) dehydrogenase 1 (EC:1.1.1.146)

Orthology

K15680

corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]

Organism

hsa Homo sapiens (human)

Pathway

hsa00140	Steroid hormone biosynthesis
hsa00980	Metabolism of xenobiotics by cytochrome P450
hsa01100	Metabolic pathways
hsa05204	Chemical carcinogenesis

Module

hsa_M00109

C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone

Disease

H01111

Cortisone reductase deficiency (CRD)

Drug target

Carbenoxolone:

D01899 D07615

Enoxolone:

D00156

Class

Metabolism; Lipid metabolism; Steroid hormone biosynthesis [PATH:hsa00140]
Metabolism; Xenobiotics biodegradation and metabolism; Metabolism of xenobiotics by cytochrome P450 [PATH:hsa00980]
Human Diseases; Cancers; Chemical carcinogenesis [PATH:hsa05204]

SSDB

Motif

Pfam:

adh_short adh_short_C2 KR THF_DHG_CYH_C Shikimate_DH NAD_binding_10 DUF1776 2-Hacid_dh_C NAD_binding_2 Epimerase SIS Eno-Rase_NADH_b ApbA AdoHcyase_NAD

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

1XU9 3TFQ 1XU7 2RBE 2BEL 4HX5 3H6K 4BB5 3BZU 3PDJ 3HFG 3FRJ 2ILT 3CZR 3CH6 3D4N 4BB6 3D5Q 3OQ1 3D3E 3FCO 3BYZ 3QQP 4HFR 3EY4 2IRW

Position

1q32-q41

AA seq 292 aa
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK

NT seq 879 nt +upstreamnt +downstreamnt
atggcttttatgaaaaaatatctcctccccattctggggctcttcatggcctactactac
tattctgcaaacgaggaattcagaccagagatgctccaaggaaagaaagtgattgtcaca
ggggccagcaaagggatcggaagagagatggcttatcatctggcgaagatgggagcccat
gtggtggtgacagcgaggtcaaaagaaactctacagaaggtggtatcccactgcctggag
cttggagcagcctcagcacactacattgctggcaccatggaagacatgaccttcgcagag
caatttgttgcccaagcaggaaagctcatgggaggactagacatgctcattctcaaccac
atcaccaacacttctttgaatctttttcatgatgatattcaccatgtgcgcaaaagcatg
gaagtcaacttcctcagttacgtggtcctgactgtagctgccttgcccatgctgaagcag
agcaatggaagcattgttgtcgtctcctctctggctgggaaagtggcttatccaatggtt
gctgcctattctgcaagcaagtttgctttggatgggttcttctcctccatcagaaaggaa
tattcagtgtccagggtcaatgtatcaatcactctctgtgttcttggcctcatagacaca
gaaacagccatgaaggcagtttctgggatagtccatatgcaagcagctccaaaggaggaa
tgtgccctggagatcatcaaagggggagctctgcgccaagaagaagtgtattatgacagc
tcactctggaccactcttctgatcagaaatccatgcaggaagatcctggaatttctctac
tcaacgagctataatatggacagattcataaacaagtag

All links

Ontology (4)   
   KEGG BRITE (4)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Disease (4)   
   KEGG DISEASE (1)   
   OMIM (3)   
Drug (3)   
   KEGG DRUG (3)   
Chemical substance (13)   
   KEGG COMPOUND (13)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (5)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (5)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (3)   
DNA sequence (23)   
   RefSeq(nuc) (3)   
   GenBank (10)   
   EMBL (10)   
3D Structure (26)   
   PDB (26)   
Protein domain (14)   
   Pfam (14)   
All databases (116)   

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