KEGG   Homo sapiens (human): 3416Help
Entry
3416              CDS       T01001                                 

Gene name
IDE, INSULYSIN
Definition
(RefSeq) insulin degrading enzyme (EC:3.4.24.56)
  KO
K01408  
insulysin [EC:3.4.24.56]
Organism
hsa  Homo sapiens (human)
Pathway
Alzheimer's disease
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    3416 (IDE)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.56  insulysin
     3416 (IDE)
Peptidases [BR:hsa01002]
 Metallo Peptidases
  Family M16: pitrilysin family
   3416 (IDE)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
10q23-q25
AA seq 1019 aa AA seqDB search
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
NT seq 3060 nt NT seq  +upstreamnt  +downstreamnt
atgcggtaccggctagcgtggcttctgcaccccgcactgcccagcaccttccgctcagtc
ctcggcgcccgcctgccgcctccggagcgcctgtgtggtttccaaaaaaagacttacagc
aaaatgaataatccagccatcaagagaataggaaatcacattaccaagtctcctgaagac
aagcgagaatatcgagggctagagctggccaatggtatcaaagtacttcttatcagtgat
cccaccacggataagtcatcagcagcacttgatgtgcacataggttcattgtcggatcct
ccaaatattgctggcttaagtcatttttgtgaacatatgctttttttgggaacaaagaaa
taccctaaagaaaatgaatacagccagtttctcagtgagcatgcaggaagttcaaatgcc
tttactagtggagagcataccaattactattttgatgtttctcatgaacacctagaaggt
gccctagacaggtttgcacagttttttctgtgccccttgttcgatgaaagttgcaaagac
agagaggtgaatgcagttgattcagaacatgagaagaatgtgatgaatgatgcctggaga
ctctttcaattggaaaaagctacagggaatcctaaacaccccttcagtaaatttgggaca
ggtaacaaatatactctggagactagaccaaaccaagaaggcattgatgtaagacaagag
ctactgaaattccattctgcttactattcatccaacttaatggctgtttgtgttttaggt
cgagaatctttagatgacttgactaatctggtggtaaagttattttctgaagtagagaac
aaaaatgttccattgccagaatttcctgaacaccctttccaagaagaacatcttaaacaa
ctttacaaaatagtacccattaaagatattaggaatctctatgtgacatttcccatacct
gaccttcagaaatactacaaatcaaatcctggtcattatcttggtcatctcattgggcat
gaaggtcctggaagtctgttatcagaacttaagtcaaagggctgggttaatactcttgtt
ggtgggcagaaggaaggagcccgaggttttatgttttttatcattaatgtggacttgacc
gaggaaggattattacatgttgaagatataattttgcacatgtttcaatacattcagaag
ttacgtgcagaaggacctcaagaatgggttttccaagagtgcaaggacttgaatgctgtt
gcttttaggtttaaagacaaagagaggccacggggctatacatctaagattgcaggaata
ttgcattattatcccctagaagaggtgctcacagcggaatatttactggaagaatttaga
cctgacttaatagagatggttctcgataaactcagaccagaaaatgtccgggttgccata
gtttctaaatcttttgaaggaaaaactgatcgcacagaagagtggtatggaacccagtac
aaacaagaagctataccggatgaagtcatcaagaaatggcaaaatgctgacctgaatggg
aaatttaaacttcctacaaagaatgaatttattcctacgaattttgagattttaccgtta
gaaaaagaggcgacaccataccctgctcttattaaggatacagctatgagcaaactttgg
ttcaaacaagatgataagttttttttgccgaaggcttgtctcaactttgaatttttcagc
ccatttgcttatgtggaccccttgcactgtaacatggcctatttgtaccttgagctcctc
aaagactcactcaacgagtatgcatatgcagcagagctagcaggcttgagctatgatctc
caaaataccatctatgggatgtatctttcagtgaaaggttacaatgacaagcagccaatt
ttactaaagaagattattgagaaaatggctacctttgagattgatgaaaaaagatttgaa
attatcaaagaagcatatatgcgatctcttaacaatttccgggctgaacagcctcaccag
catgccatgtactacctccgcttgctgatgactgaagtggcctggactaaagatgagtta
aaagaagctctggatgatgtaacccttcctcgccttaaggccttcatacctcagctcctg
tcacggctgcacattgaagcccttctccatggaaacataacaaagcaggctgcattagga
attatgcagatggttgaagacaccctcattgaacatgctcataccaaacctctccttcca
agtcagctggttcggtatagagaagttcagctccctgacagaggatggtttgtttatcag
cagagaaatgaagttcacaataactgtggcatcgagatatactaccaaacagacatgcaa
agcacctcagagaatatgtttctggagctcttctgtcagattatctcggaaccttgcttc
aacaccctgcgcaccaaggagcagttgggctatatcgtcttcagcgggccacgtcgagct
aatggcatacagggcttgagattcatcatccagtcagaaaagccacctcactacctagaa
agcagagtggaagctttcttaattaccatggaaaagtccatagaggacatgacagaagag
gccttccaaaaacacattcaggcattagcaattcgtcgactagacaaaccaaagaagcta
tctgctgagtgtgctaaatactggggagaaatcatctcccagcaatataattttgacaga
gataacactgaggttgcatatttaaagacacttaccaaggaagatatcatcaaattctac
aaggaaatgttggcagtagatgctccaaggagacataaggtatccgtccatgttcttgcc
agggaaatggattcttgtcctgttgttggagagttcccatgtcaaaatgacataaatttg
tcacaagcaccagccttgccacaacctgaagtgattcagaacatgaccgaattcaagcgt
ggtctgccactgtttccccttgtgaaaccacatattaacttcatggctgcaaaactctga

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