KEGG   Homo sapiens (human): 3455Help
Entry
3455              CDS       T01001                                 

Gene name
IFNAR2, IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45
Definition
(RefSeq) interferon alpha and beta receptor subunit 2
  KO
K05131  
interferon receptor 2
Organism
hsa  Homo sapiens (human)
Pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Necroptosis
Osteoclast differentiation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
Hepatitis C
Measles
Influenza A
Human papillomavirus infection
Kaposi's sarcoma-associated herpesvirus infection
Herpes simplex infection
Pathways in cancer
Network
N00053  
Cytokine-Jak-STAT signaling pathway
N00150  
Type I IFN signaling pathway
Drug target
Albinterferon alfa-2b: 
Interferon alfa natural: 
Interferon alfa-2a: 
Interferon alfa-2b: 
Interferon alfa-n1: 
Interferon alfacon-1: 
Interferon beta natural: 
Interferon beta-1a: 
Interferon beta-1b: 
Peginterferon alfa-2a: 
Peginterferon alfa-2b: 
Peginterferon beta-1a: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    3455 (IFNAR2)
   04151 PI3K-Akt signaling pathway
    3455 (IFNAR2)
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3455 (IFNAR2)
 Cellular Processes
  Cell growth and death
   04217 Necroptosis
    3455 (IFNAR2)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    3455 (IFNAR2)
   04621 NOD-like receptor signaling pathway
    3455 (IFNAR2)
   04650 Natural killer cell mediated cytotoxicity
    3455 (IFNAR2)
  Development
   04380 Osteoclast differentiation
    3455 (IFNAR2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    3455 (IFNAR2)
  Infectious diseases
   05162 Measles
    3455 (IFNAR2)
   05164 Influenza A
    3455 (IFNAR2)
   05160 Hepatitis C
    3455 (IFNAR2)
   05168 Herpes simplex infection
    3455 (IFNAR2)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    3455 (IFNAR2)
   05165 Human papillomavirus infection
    3455 (IFNAR2)
Cytokine receptors [BR:hsa04050]
 Class II cytokine receptor (interferon/IL-10 family receptor)
  3455 (IFNAR2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
P48551(Tclin)
UniProt: 
Structure
PDB: 

Jmol
Position
21q22.11
AA seq 515 aa AA seqDB search
MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS
IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF
SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK
HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAE
SAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMD
MVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLI
DPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGR
ITFNVDLNSVFLRVLDDEDSDDLEAPLMLSSHLEEMVDPEDPDNVQSNHLLASGEGTQPT
FPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR
NT seq 1548 nt NT seq  +upstreamnt  +downstreamnt
atgcttttgagccagaatgccttcatcttcagatcacttaatttggttctcatggtgtat
atcagcctcgtgtttggtatttcatatgattcgcctgattacacagatgaatcttgcact
ttcaagatatcattgcgaaatttccggtccatcttatcatgggaattaaaaaaccactcc
attgtaccaactcactatacattgctgtatacaatcatgagtaaaccagaagatttgaag
gtggttaagaactgtgcaaataccacaagatcattttgtgacctcacagatgagtggaga
agcacacacgaggcctatgtcaccgtcctagaaggattcagcgggaacacaacgttgttc
agttgctcacacaatttctggctggccatagacatgtcttttgaaccaccagagtttgag
attgttggttttaccaaccacattaatgtgatggtgaaatttccatctattgttgaggaa
gaattacagtttgatttatctctcgtcattgaagaacagtcagagggaattgttaagaag
cataaacccgaaataaaaggaaacatgagtggaaatttcacctatatcattgacaagtta
attccaaacacgaactactgtgtatctgtttatttagagcacagtgatgagcaagcagta
ataaagtctcccttaaaatgcaccctccttccacctggccaggaatcagaatcagcagaa
tctgccaaaataggaggaataattactgtgtttttgatagcattggtcttgacaagcacc
atagtgacactgaaatggattggttatatatgcttaagaaatagcctccccaaagtcttg
aattttcataactttttagcctggccatttcctaacctgccaccgttggaagccatggat
atggtggaggtcatttacatcaacagaaagaagaaagtgtgggattataattatgatgat
gaaagtgatagcgatactgaggcagcgcccaggacaagtggcggtggctataccatgcat
ggactgactgtcaggcctctgggtcaggcctctgccacctctacagaatcccagttgata
gacccggagtccgaggaggagcctgacctgcctgaggttgatgtggagctccccacgatg
ccaaaggacagccctcagcagttggaactcttgagtgggccctgtgagaggagaaagagt
ccactccaggacccttttcccgaagaggactacagctccacggaggggtctgggggcaga
attaccttcaatgtggacttaaactctgtgtttttgagagttcttgatgacgaggacagt
gacgacttagaagcccctctgatgctatcgtctcatctggaagagatggttgacccagag
gatcctgataatgtgcaatcaaaccatttgctggccagcggggaagggacacagccaacc
tttcccagcccctcttcagagggcctgtggtccgaagatgctccatctgatcaaagtgac
acttctgagtcagatgttgaccttggggatggttatataatgagatga

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