KEGG   Homo sapiens (human): 3636Help
Entry
3636              CDS       T01001                                 

Gene name
INPPL1, OPSMD, SHIP2
Definition
inositol polyphosphate phosphatase-like 1 (EC:3.1.3.86)
Orthology
K15909  
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]
Organism
hsa  Homo sapiens (human)
Pathway
Inositol phosphate metabolism
Phosphatidylinositol signaling system
B cell receptor signaling pathway
Fc gamma R-mediated phagocytosis
Insulin signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    3636 (INPPL1)
 Environmental Information Processing
  Signal transduction
   04070 Phosphatidylinositol signaling system
    3636 (INPPL1)
 Organismal Systems
  Immune system
   04662 B cell receptor signaling pathway
    3636 (INPPL1)
   04666 Fc gamma R-mediated phagocytosis
    3636 (INPPL1)
  Endocrine system
   04910 Insulin signaling pathway
    3636 (INPPL1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.86  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
     3636 (INPPL1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
11q13
AA seq 1258 aa AA seqDB search
MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCV
LYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGE
REPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAPNGLST
VSHDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRLHSEVDKVLSGLEILSKVFDQQS
SPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPQPS
TRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFT
HDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDE
PDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDRE
WLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGN
KGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFT
HLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPT
YRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSP
VFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKS
FENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVA
LKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGAKS
KAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPR
LKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAIT
VPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGR
GGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGP
ARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRASGLGEAG
MSAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK
NT seq 3777 nt NT seq  +upstreamnt  +downstreamnt
atggcctcggcctgcggggcgccgggcccggggggcgccctgggcagccaggccccctcc
tggtaccaccgcgacctgagccgggcggccgcggaggagctgctggcccgggcgggccgc
gatggcagcttcctggtccgagacagcgagagcgtggcgggggccttcgcgctctgcgtc
ctgtatcagaagcatgtgcacacgtatcgcattctgcctgatggagaagatttcttggct
gtgcagacctcgcagggtgtgcctgtgcgccgcttccagaccctgggtgagctcatcggc
ctgtacgcccagcccaaccagggccttgtgtgcgccctgcttcttcctgtagagggtgag
cgagagccggacccaccggatgaccgggatgcctcagatggggaggatgagaagcccccg
ctgcccccgcgctctggctccaccagcatttctgcccccactgggcccagcagtcccctg
ccagctcctgagactcccacagctccagctgctgagagtgctcccaatgggctgagcacc
gtctcgcacgactacctgaaaggcagctatgggctggacctggaagctgtgaggggtgga
gccagccacctgccccacctcacccgtaccctcgctacctcatgccggaggctgcacagt
gaggtggacaaggtcctgtcaggcctggagatcctgtccaaggtgtttgaccagcagagc
tcgcccatggtgacccgccttttgcagcagcagaacctgccacagacaggggagcaggaa
ctagagagcctggtgctgaagctgtcagtgctaaaggacttcctgtcaggcatccagaag
aaggccctgaaggccctacaggacatgagctccacagcacccccagctccgcagccatcc
acacgtaaggccaagaccatccccgtgcaggcctttgaggtgaagctagatgtgaccctg
ggtgacctgaccaagattgggaagtcacagaagttcacgctgagcgtggatgtggagggt
gggcggctggtgctgctgcggagacagcgggactcccaggaggactggaccaccttcacg
cacgaccgcatccgccagctcattaagtcccagcgtgtccagaacaagctgggtgttgtg
tttgagaaggagaaggaccggactcagcgcaaggacttcatctttgtcagtgcccggaag
cgggaggccttctgccagctgttgcagctcatgaagaacaagcactccaagcaggacgag
cccgacatgatctcagtcttcataggcacctggaacatgggaagtgtaccacctccaaaa
aacgtgacatcctggttcacatcgaagggtctggggaagaccctggacgaggtcacagtg
accataccccatgacatctatgtctttgggacccaggagaactcagtgggcgaccgcgag
tggctggacctactgcgcgggggcctcaaggagcttacggatctggattaccgcccgatt
gccatgcaatcactgtggaatatcaaggtggcagtgctggtcaagccagagcacgagaac
cgtatcagccatgtcagtacgtccagtgtgaagactggcatcgccaacaccctggggaac
aagggggctgtgggcgtctccttcatgtttaatggcacctcatttggctttgtgaattgt
cacctcacctcgggaaatgagaagacggctcggaggaaccaaaactacttggacatcctg
cggctgctctcgctgggcgaccggcagctcaatgcctttgacatctctctgcgtttcaca
cacctcttctggtttggggacctcaactaccgcctggacatggatatccaggagatcctg
aactacatcagcaggaaagagtttgagcccctcctcagggtggaccagctcaacctggag
cgggagaagcacaaggtcttccttcgattcagtgaggaggagatctccttcccacccacc
taccgctatgagcggggttcccgggacacatatgcctggcacaagcagaagccaactggg
gtccggaccaatgtgccctcatggtgtgaccggattctgtggaaatcctaccctgaaact
cacatcatctgcaattcttatggttgcactgatgacatcgtcaccagcgaccattccccc
gtgtttgggacatttgaggttggagttacctcccagttcatctccaagaaagggctctca
aagacttcagaccaggcctacattgagtttgagagcatcgaggccattgtgaagacagcc
agccgcaccaagttcttcatcgagttctactctacctgcctggaggaatacaagaagagc
tttgagaatgatgcccagagcagtgacaacatcaacttcctcaaagtgcagtggtcttca
cgccagctgcccacgctcaaaccaattctggctgatatcgagtacctgcaggaccagcac
ctcctgctcacagtcaagtccatggatggctatgaatcctatggggagtgtgtggttgca
ctcaaatccatgatcggcagcacggcccaacagttcctgaccttcctatcccaccgtggc
gaggagacaggcaatatcagaggctccatgaaggtgcgggtgcccacggagcgcctgggc
acccgtgagcggctctacgagtggatcagcattgataaggatgaggcaggagcaaagagc
aaagccccctctgtgtcccgagggagccaggagcccaggtcagggagccgcaagccagcc
ttcacagaggcctcctgcccgctctccaggttatttgaagaaccagagaaaccgccacca
acggggaggcccccagccccaccccgagcagctccccgggaggagcccttgacccccagg
ttgaagccagagggagctcctgaaccagaaggggtggcggcccccccacccaagaacagc
ttcaataaccctgcctactacgtccttgaaggggtcccgcaccagctgctgcccccggag
ccaccctcgcctgccagggcccctgtcccatctgccaccaagaacaaagtggccattaca
gtgcctgctccacagcttgggcaccaccggcaccctcgtgtgggagaggggagttcttca
gatgaggagtctggaggcacactgccccctccagactttccacctccaccactgccggac
tcagccatcttcctgccccccagcctggatcctttaccagggccagtggtccggggccgt
ggtggggctgaggcccgtggcccaccacctcccaaggcccatccaaggcctccactgccc
ccaggcccctcaccagccagcactttcctgggggaagtggccagtggggatgaccggtcc
tgctcggtgctgcagatggccaagacgctgagcgaggtggactatgcccctgctgggcct
gcacgctcagcgctcctcccaggccccctggagctgcagcccccccggggactgccctcg
gactatggccggcccctcagcttccctccaccccgcatccgggagagcatccaggaagac
ctggcagaggaggctccgtgcctgcagggcgggcgggccagcgggctgggcgaggcaggc
atgagtgcctggctgcgggccatcggcttggagcgctatgaggagggcctggtgcataat
ggctgggacgacctggagtttctcagtgacatcaccgaggaggacttggaggaggctggg
gtgcaggacccggctcacaagcgcctccttctggacaccctgcagctcagcaagtga

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