KEGG   Homo sapiens (human): 3667Help
Entry
3667              CDS       T01001                                 

Gene name
IRS1, HIRS-1
Definition
insulin receptor substrate 1
Orthology
K16172  
insulin receptor substrate 1
Organism
hsa  Homo sapiens (human)
Pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Class
Environmental Information Processing; Signal transduction; PI3K-Akt signaling pathway [PATH:hsa04151]
Environmental Information Processing; Signal transduction; mTOR signaling pathway [PATH:hsa04150]
Organismal Systems; Endocrine system; Insulin signaling pathway [PATH:hsa04910]
Organismal Systems; Endocrine system; Adipocytokine signaling pathway [PATH:hsa04920]
Organismal Systems; Excretory system; Aldosterone-regulated sodium reabsorption [PATH:hsa04960]
Organismal Systems; Nervous system; Neurotrophin signaling pathway [PATH:hsa04722]
Human Diseases; Endocrine and metabolic diseases; Type II diabetes mellitus [PATH:hsa04930]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
UniProt: 
Structure
PDB: 

Jmol
Position
2q36
AA seq 1242 aa AA seqDB search
MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPN
GHYILSRGGNGHRCTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTRSYPEEGLEMHPLERRGGHHR
PDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN
GYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGTSYGKLWTNGVGGHHSHVLPHPKPPVES
SGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEP
EEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPH
LPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQPLLHPPEPKSPGEYVNIE
FGSDQSGYLSGPVAFHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQESTGV
EMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIA
AEEVSLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSPN
RNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSSSSEDVKR
HSSASFENVWLRPGELGGAPKEPAKLCGAAGGLENGLNYIDLDLVKDFKQCPQECTPEPQ
PPPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDRQ
NT seq 3729 nt NT seq  +upstreamnt  +downstreamnt
atggcgagccctccggagagcgatggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagcatgcacaaacgcttcttcgtactgcgcgcggccagcgaggctgggggc
ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatcccccttgagagctgcttcaacatcaacaagcgggctgactccaagaac
aagcacctggtggctctctacacccgggacgagcactttgccatcgcggcggacagcgag
gccgagcaagacagctggtaccaggctctcctacagctgcacaaccgtgctaagggccac
cacgacggagctgcggccctcggggcgggaggtggtgggggcagctgcagcggcagctcc
ggccttggtgaggctggggaggacttgagctacggtgacgtgcccccaggacccgcattc
aaagaggtctggcaagtgatcctgaagcccaagggcctgggtcagacaaagaacctgatt
ggtatctaccgcctttgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag
gcagcggccgtggtgctgcagctgatgaacatcaggcgctgtggccactcggaaaacttc
ttcttcatcgaggtgggccgttctgccgtgacggggcccggggagttctggatgcaggtg
gatgactctgtggtggcccagaacatgcacgagaccatcctggaggccatgcgggccatg
agtgatgagttccgccctcgcagcaagagccagtcctcgtccaactgctctaaccccatc
agcgtccccctgcgccggcaccatctcaacaatcccccgcccagccaggtggggctgacc
cgccgatcacgcactgagagcatcaccgccacctccccggccagcatggtgggcgggaag
ccaggctccttccgtgtccgcgcctccagtgacggcgaaggcaccatgtcccgcccagcc
tcggtggacggcagccctgtgagtcccagcaccaacagaacccacgcccaccggcatcgg
ggcagcgcccggctgcaccccccgctcaaccacagccgctccatccccatgccggcttcc
cgctgctcgccttcggccaccagcccggtcagtctgtcgtccagtagcaccagtggccat
ggctccacctcggattgtctcttcccacggcgatctagtgcttcggtgtctggttccccc
agcgatggcggtttcatctcctcggatgagtatggctccagtccctgcgatttccggagt
tccttccgcagtgtcactccggattccctgggccacaccccaccagcccgcggtgaggag
gagctaagcaactatatctgcatgggtggcaaggggccctccaccctgaccgcccccaac
ggtcactacattttgtctcggggtggcaatggccaccgctgcaccccaggaacaggcttg
ggcacgagtccagccttggctggggatgaagcagccagtgctgcagatctggataatcgg
ttccgaaagagaactcactcggcaggcacatcccctaccattacccaccagaagaccccg
tcccagtcctcagtggcttccattgaggagtacacagagatgatgcctgcctacccacca
ggaggtggcagtggaggccgactgccgggacacaggcactccgccttcgtgcccacccgc
tcctacccagaggagggtctggaaatgcaccccttggagcgtcggggggggcaccaccgc
ccagacagctccaccctccacacggatgatggctacatgcccatgtccccaggggtggcc
ccagtgcccagtggccgaaagggcagtggagactatatgcccatgagccccaagagcgta
tctgccccacagcagatcatcaatcccatcagacgccatccccagagagtggaccccaat
ggctacatgatgatgtcccccagcggtggctgctctcctgacattggaggtggccccagc
agcagcagcagcagcagcaacgccgtcccttccgggaccagctatggaaagctgtggaca
aacggggtagggggccaccactctcatgtcttgcctcaccccaaacccccagtggagagc
agcggtggtaagctcttaccttgcacaggtgactacatgaacatgtcaccagtgggggac
tccaacaccagcagcccctccgactgctactacggccctgaggacccccagcacaagcca
gtcctctcctactactcattgccaagatcctttaagcacacccagcgccccggggagccg
gaggagggtgcccggcatcagcacctccgcctttccactagctctggtcgccttctctat
gctgcaacagcagatgattcttcctcttccaccagcagcgacagcctgggtgggggatac
tgcggggctaggctggagcccagccttccacatccccaccatcaggttctgcagccccat
ctgcctcgaaaggtggacacagctgctcagaccaatagccgcctggcccggcccacgagg
ctgtccctgggggatcccaaggccagcaccttacctcgggcccgagagcagcagcagcag
cagcagcccttgctgcaccctccagagcccaagagcccgggggaatatgtcaatattgaa
tttgggagtgatcagtctggctacttgtctggcccggtggctttccacagctcaccttct
gtcaggtgtccatcccagctccagccagctcccagagaggaagagactggcactgaggag
tacatgaagatggacctggggccgggccggagggcagcctggcaggagagcactggggtc
gagatgggcagactgggccctgcacctcccggggctgctagcatttgcaggcctacccgg
gcagtgcccagcagccggggtgactacatgaccatgcagatgagttgtccccgtcagagc
tacgtggacacctcgccagctgcccctgtaagctatgctgacatgcgaacaggcattgct
gcagaggaggtgagcctgcccagggccaccatggctgctgcctcctcatcctcagcagcc
tctgcttccccgactgggcctcaaggggcagcagagctggctgcccactcgtccctgctg
gggggcccacaaggacctgggggcatgagcgccttcacccgggtgaacctcagtcctaac
cgcaaccagagtgccaaagtgatccgtgcagacccacaagggtgccggcggaggcatagc
tccgagactttctcctcaacacccagtgccacccgggtgggcaacacagtgccctttgga
gcgggggcagcagtagggggcggtggcggtagcagcagcagcagcgaggatgtgaaacgc
cacagctctgcttcctttgagaatgtgtggctgaggcctggggagcttgggggagccccc
aaggagccagccaaactgtgtggggctgctgggggtttggagaatggtcttaactacata
gacctggatttggtcaaggacttcaaacagtgccctcaggagtgcacccctgaaccgcag
cctcccccacccccaccccctcatcaacccctgggcagcggtgagagcagctccacccgc
cgctcaagtgaggatttaagcgcctatgccagcatcagtttccagaagcagccagaggac
cgtcagtag

DBGET integrated database retrieval system