KEGG   Homo sapiens (human): 369Help
Entry
369               CDS       T01001                                 

Gene name
ARAF, A-RAF, ARAF1, PKS2, RAFA1
Definition
(RefSeq) A-Raf proto-oncogene, serine/threonine kinase
  KO
K08845  
A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
FoxO signaling pathway
Vascular smooth muscle contraction
Natural killer cell mediated cytotoxicity
Long-term potentiation
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Alcoholism
Hepatitis C
Pathways in cancer
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Module
MAPK (ERK1/2) signaling
Network
N00001  
EGF-EGFR-RAS-ERK signaling pathway
N00002  
BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003  
Mutation-activated KIT to RAS-ERK signaling pathway
N00004  
Duplication-activated FLT3 to RAS-ERK signaling pathway
N00005  
Mutation-activated MET to RAS-ERK signaling pathway
N00006  
Amplified EGFR to RAS-ERK signaling pathway
N00007  
EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008  
RET-PTC fusion kinase to RAS-ERK signaling pathway
N00009  
TRK fusion kinase to RAS-ERK signaling pathway
N00011  
Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00012  
Mutation-activated KRAS/NRAS to ERK signaling pathway
N00014  
Mutation-activated EGFR to RAS-ERK signaling pathway
N00015  
PDGF-PDGFR-RAS-ERK signaling pathway
N00016  
PDGF-overexpression to RAS-ERK signaling pathway
N00018  
Amplified PDGFR to RAS-ERK signaling pathway
N00019  
FGF-FGFR-RAS-ERK signaling pathway
N00020  
Amplified FGFR to RAS-ERK signaling pathway
N00021  
EGF-ERBB2-RAS-ERK signaling pathway
N00022  
ERBB2-overexpression to RAS-ERK signaling pathway
N00023  
EGF-EGFR-PLCG-ERK signaling pathway
N00024  
Mutation-activated EGFR to PLCG-ERK signaling pathway
N00025  
EML4-ALK fusion kinase to PLCG-ERK signaling pathway
N00041  
EGFR-overexpression to RAS-ERK signaling pathway
N00077  
HRAS-overexpression to RAS-ERK signaling pathway
N00078  
Mutation-activated HRAS to RAS-ERK signaling pathway
N00160  
KSHV K1 to RAS-ERK signaling pathway
N00215  
KITLG-KIT-RAS-ERK signaling pathway
N00216  
HGF-MET-RAS-ERK signaling pathway
N00217  
FLT3LG-FLT3-RAS-ERK signaling pathway
N00229  
TGFA-EGFR-RAS-ERK signaling pathway
N00230  
TGFA-overexpression to RAS-ERK signaling pathway
N00233  
IGF2-IGF1R-RAS-ERK signaling pathway
N00235  
IGF2-overexpression to RAS-ERK signaling pathway
N00237  
IGF1R-overexpression to RAS-ERK signaling pathway
N00246  
HGF-overexpression to RAS-ERK signaling pathway
N00248  
MET-overexpression to RAS-ERK signaling pathway
N00252  
Amplified ERBB2 to RAS-ERK signaling pathway
N00259  
Amplified MET to RAS-ERK signaling pathway
Disease
H00523  
Noonan syndrome and related disorders
H01738  
Noonan syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    369 (ARAF)
   04012 ErbB signaling pathway
    369 (ARAF)
   04068 FoxO signaling pathway
    369 (ARAF)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    369 (ARAF)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    369 (ARAF)
  Endocrine system
   04910 Insulin signaling pathway
    369 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    369 (ARAF)
  Circulatory system
   04270 Vascular smooth muscle contraction
    369 (ARAF)
  Nervous system
   04726 Serotonergic synapse
    369 (ARAF)
   04720 Long-term potentiation
    369 (ARAF)
   04730 Long-term depression
    369 (ARAF)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    369 (ARAF)
   05205 Proteoglycans in cancer
    369 (ARAF)
   05210 Colorectal cancer
    369 (ARAF)
   05212 Pancreatic cancer
    369 (ARAF)
   05225 Hepatocellular carcinoma
    369 (ARAF)
   05226 Gastric cancer
    369 (ARAF)
   05214 Glioma
    369 (ARAF)
   05221 Acute myeloid leukemia
    369 (ARAF)
   05220 Chronic myeloid leukemia
    369 (ARAF)
   05218 Melanoma
    369 (ARAF)
   05211 Renal cell carcinoma
    369 (ARAF)
   05219 Bladder cancer
    369 (ARAF)
   05215 Prostate cancer
    369 (ARAF)
   05213 Endometrial cancer
    369 (ARAF)
   05224 Breast cancer
    369 (ARAF)
   05223 Non-small cell lung cancer
    369 (ARAF)
  Substance dependence
   05034 Alcoholism
    369 (ARAF)
  Infectious diseases
   05160 Hepatitis C
    369 (ARAF)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    369 (ARAF)
   01522 Endocrine resistance
    369 (ARAF)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     369 (ARAF)
Protein kinases [BR:hsa01001]
 Serine/threonine protein kinases: TKL group
  RAF family [OT]
   369 (ARAF)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
P10398(Tbio)
UniProt: 
Structure
PDB: 

Jmol
Position
Xp11.3
AA seq 606 aa AA seqDB search
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt NT seq  +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaatggggccgagccatcccgggcagtgggcacc
gtcaaagtatacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctgaaggtgcggggtctaaatcaggactgctgtgtg
gtctaccgactcatcaagggacgaaagacggtcactgcctgggacacagccattgctccc
ctggatggcgaggagctcattgtcgaggtccttgaagatgtcccgctgaccatgcacaat
tttgtacggaagaccttcttcagcctggcgttctgtgacttctgccttaagtttctgttc
catggcttccgttgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccaacagttctaccacagtgtccaggat
ttgtccggaggctccagacagcatgaggctccctcgaaccgccccctgaatgagttgcta
accccccagggtcccagcccccgcacccagcactgtgacccggagcacttccccttccct
gccccagccaatgcccccctacagcgcatccgctccacgtccactcccaacgtccatatg
gtcagcaccacggcccccatggactccaacctcatccagctcactggccagagtttcagc
actgatgctgccggtagtagaggaggtagtgatggaaccccccgggggagccccagccca
gccagcgtgtcctcggggaggaagtccccacattccaagtcaccagcagagcagcgcgag
cggaagtccttggccgatgacaagaagaaagtgaagaacctggggtaccgggactcaggc
tattactgggaggtaccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgagggcggtggcatggcgatgtggccgtgaaggtgctcaaggtg
tcccagcccacagctgagcaggcccaggctttcaagaatgagatgcaggtgctcaggaag
acgcgacatgtcaacatcttgctgtttatgggcttcatgacccggccgggatttgccatc
atcacacagtggtgtgagggctccagcctctaccatcacctgcatgtggccgacacacgc
ttcgacatggtccagctcatcgacgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacaacatcttcctacatgagggg
ctcacggtgaagatcggtgactttggcttggccacagtgaagactcgatggagcggggcc
cagcccttggagcagccctcaggatctgtgctgtggatggcagctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcagacgtctatgcctacggggttgtgctctac
gagcttatgactggctcactgccttacagccacattggctgccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggagcggcccctcttc
ccccagatcctggccacaattgagctgctgcaacggtcactccccaagattgagcggagt
gcctcggaaccctccttgcaccgcacccaggccgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag

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