KEGG T01001: 3702

Homo sapiens (human): 3702

Entry

3702 CDS T01001

Gene name

ITK, EMT, LYK, PSCTK2

Definition

IL2-inducible T-cell kinase (EC:2.7.10.2)

Orthology

K07363

IL2-inducible T-cell kinase [EC:2.7.10.2]

Organism

hsa Homo sapiens (human)

Pathway

hsa04062	Chemokine signaling pathway
hsa04660	T cell receptor signaling pathway
hsa04670	Leukocyte transendothelial migration

Disease

H00107

Other well-defined immunodeficiency syndromes

Class

Organismal Systems; Immune system; T cell receptor signaling pathway [PATH:hsa04660]
Organismal Systems; Immune system; Leukocyte transendothelial migration [PATH:hsa04670]
Organismal Systems; Immune system; Chemokine signaling pathway [PATH:hsa04062]

SSDB

Motif

Pfam:

Pkinase_Tyr Pkinase SH2 BTK SH3_1 PH SH3_9 SH3_2 SH3_3 PH_8 APH PH_3 Kinase-like

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

4HCU 4HCT 4HCV 3T9T 3MIY 3MJ1 3V5L 3MJ2 3V8T 3QGW 3QGY 3V8W 1SM2 1SNU 3V5J 1SNX 2LMJ 2YUQ 2E6I

Position

5q31-q32

AA seq 620 aa
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL

NT seq 1863 nt +upstreamnt +downstreamnt
atgaacaactttatcctcctggaagaacagctcatcaagaaatcccaacaaaagagaaga
acttctccctcgaactttaaagtccgcttctttgtgttaaccaaagccagcctggcatac
tttgaagatcgtcatgggaagaagcgcacgctgaaggggtccattgagctctcccgaatc
aaatgtgttgagattgtgaaaagtgacatcagcatcccatgccactataaatacccgttt
caggtggtgcatgacaactacctcctatatgtgtttgctccagatcgtgagagccggcag
cgctgggtgctggcccttaaagaagaaacgaggaataataacagtttggtgcctaaatat
catcctaatttctggatggatgggaagtggaggtgctgttctcagctggagaagcttgca
acaggctgtgcccaatatgatccaaccaagaatgcttcaaagaagcctcttcctcctact
cctgaagacaacaggcgaccactttgggaacctgaagaaactgtggtcattgccttatat
gactaccaaaccaatgatcctcaggaactcgcactgcggcgcaacgaagagtactgcctg
ctggacagttctgagattcactggtggagagtccaggacaggaatgggcatgaaggatat
gtaccaagcagttatctggtggaaaaatctccaaataatctggaaacctatgagtggtac
aataagagtatcagccgagacaaagctgaaaaacttcttttggacacaggcaaagaagga
gccttcatggtaagggattccaggactgcaggaacatacaccgtgtctgttttcaccaag
gctgttgtaagtgagaacaatccctgtataaagcattatcacatcaaggaaacaaatgac
aatcctaagcgatactatgtggctgaaaagtatgtgttcgattccatccctcttctcatc
aactatcaccaacataatggaggaggcctggtgactcgactccggtatccagtttgtttt
gggaggcagaaagccccagttacagcagggctgagatacgggaaatgggtgatcgacccc
tcagagctcacttttgtgcaagagattggcagtgggcaatttgggttggtgcatctgggc
tactggctcaacaaggacaaggtggctatcaaaaccattcgggaaggggctatgtcagaa
gaggacttcatagaggaggctgaagtaatgatgaaactctctcatcccaaactggtgcag
ctgtatggggtgtgcctggagcaggcccccatctgcctggtgtttgagttcatggagcac
ggctgcctgtcagattatctacgcacccagcggggactttttgctgcagagaccctgctg
ggcatgtgtctggatgtgtgtgagggcatggcctacctggaagaggcatgtgtcatccac
agagacttggctgccagaaattgtttggtgggagaaaaccaagtcatcaaggtgtctgac
tttgggatgacaaggttcgttctggatgatcagtacaccagttccacaggcaccaaattc
ccggtgaagtgggcatccccagaggttttctctttcagtcgctatagcagcaagtccgat
gtgtggtcatttggtgtgctgatgtgggaagttttcagtgaaggcaaaatcccgtatgaa
aaccgaagcaactcagaggtggtggaagacatcagtaccggatttcggttgtacaagccc
cggctggcctccacacacgtctaccagattatgaatcactgctggaaagagagaccagaa
gatcggccagccttctccagactgctgcgtcaactggctgaaattgcagaatcaggactt
tag

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (8)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (17)   
   RefSeq(nuc) (1)   
   GenBank (8)   
   EMBL (8)   
3D Structure (19)   
   PDB (19)   
Protein domain (13)   
   Pfam (13)   
All databases (76)   

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