| Entry |
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| Gene name |
KARS, CMTRIB, KARS1, KARS2, KRS
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| Definition |
lysyl-tRNA synthetase (EC:6.1.1.6)
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| Orthology |
| lysyl-tRNA synthetase, class II [EC: 6.1.1.6] |
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| Organism |
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| Pathway |
| Aminoacyl-tRNA biosynthesis |
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| Module |
| Aminoacyl-tRNA biosynthesis, eukaryotes |
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| Disease |
| Charcot-Marie-Tooth disease (CMT) |
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| Class |
Genetic Information Processing; Translation; Aminoacyl-tRNA biosynthesis [PATH: hsa00970]
 |
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| SSDB |
   |
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| Motif |
 |
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| Other DBs |
NCBI-GI: NCBI-GeneID: OMIM: HGNC: HPRD: Ensembl: Vega: UniProt: |
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| Structure |
PDB: |
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| Position |
16q23.1
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| AA seq |
625 aa  
MLTQAAVRLVRGSLRKTSWAEWGHRELRLGQLAPFTAPHKDKSFSDQRSELKRRLKAEKK
VAEKEAKQKELSEKQLSQATAAATNHTTDNGVGPEEESVDPNQYYKIRSQAIHQLKVNGE
DPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGV
KLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHM
LPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMN
IIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHN
PEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFR
RINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFL
EVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLF
EEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPA
MKPEDKKENVATTDTLESTTVGTSV |
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| NT seq |
1878 nt  +upstreamnt +downstreamnt
atgttgacgcaagctgctgtaaggcttgttagggggtccctgcgcaaaacctcctgggca
gagtggggtcacagggaactgcgactgggtcaacttgctcctttcacagcgcctcacaag
gacaagtcattttctgatcaaagaagtgagctgaagagacgcctgaaagctgagaagaaa
gtagcagagaaggaggccaaacagaaagagctcagtgagaaacagctaagccaagccact
gctgctgccaccaaccacaccactgataatggtgtgggtcctgaggaagagagcgtggac
ccaaatcaatactacaaaatccgcagtcaagcaattcatcagctgaaggtcaatggggaa
gacccatacccacacaagttccatgtagacatctcactcactgacttcatccaaaaatat
agtcacctgcagcctggggatcacctgactgacatcaccttaaaggtggcaggtaggatc
catgccaaaagagcttctgggggaaagctcatcttctatgatcttcgaggagagggggtg
aagttgcaagtcatggccaattccagaaattataaatcagaagaagaatttattcatatt
aataacaaactgcgtcggggagacataattggagttcaggggaatcctggtaaaaccaag
aagggtgagctgagcatcattccgtatgagatcacactgctgtctccctgtttgcatatg
ttacctcatcttcactttggcctcaaagacaaggaaacaaggtatcgccagagatacttg
gacttgatcctgaatgactttgtgaggcagaaatttatcatccgctctaagatcatcaca
tatataagaagtttcttagatgagctgggattcctagagattgaaactcccatgatgaac
atcatcccagggggagccgtggccaagcctttcatcacttatcacaacgagctggacatg
aacttatatatgagaattgctccagaactctatcataagatgcttgtggttggtggcatc
gaccgggtttatgaaattggacgccagttccggaatgaggggattgatttgacgcacaat
cctgagttcaccacctgtgagttctacatggcctatgcagactatcacgatctcatggaa
atcacggagaagatggtttcagggatggtgaagcatattacaggcagttacaaggtcacc
taccacccagatggcccagagggccaagcctacgatgttgacttcaccccacccttccgg
cgaatcaacatggtagaagagcttgagaaagccctggggatgaagctgccagaaacgaac
ctctttgaaactgaagaaactcgcaaaattcttgatgatatctgtgtggcaaaagctgtt
gaatgccctccacctcggaccacagccaggctccttgacaagcttgttggggagttcctg
gaagtgacttgcatcaatcctacattcatctgtgatcacccacagataatgagccctttg
gctaaatggcaccgctctaaagagggtctgactgagcgctttgagctgtttgtcatgaag
aaagagatatgcaatgcgtatactgagctgaatgatcccatgcggcagcggcagcttttt
gaagaacaggccaaggccaaggctgcaggtgatgatgaggccatgttcatagatgaaaac
ttctgtactgccctggaatatgggctgccccccacagctggctggggcatgggcattgat
cgagtcgccatgtttctcacggactccaacaacatcaaggaagtacttctgtttcctgcc
atgaaacccgaagacaagaaggagaatgtagcaaccactgatacactggaaagcacaaca
gttggcacttctgtctag |
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