KEGG   Homo sapiens (human): 4018
Entry
4018              CDS       T01001                                 
Symbol
LPA, AK38, APOA, LP
Name
(RefSeq) lipoprotein(a)
  KO
K09644  apolipoprotein(a) [EC:3.4.21.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04979  Cholesterol metabolism
Drug target
Muvalaplin: D12460
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09154 Digestive system
   04979 Cholesterol metabolism
    4018 (LPA)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    4018 (LPA)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   4018 (LPA)
SSDB
Motif
Pfam: Kringle Trypsin DUF1986 Trypsin_2
Other DBs
NCBI-GeneID: 4018
NCBI-ProteinID: NP_005568
OMIM: 152200
HGNC: 6667
Ensembl: ENSG00000198670
UniProt: P08519
Structure
Position
6:complement(160531482..160664275)
AA seq 2040 aa
MEHKEVVLLLLLFLKSAAPEQSHVVQDCYHGDGQSYRGTYSTTVTGRTCQAWSSMTPHQH
NRTTENYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTP
VPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEY
YPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEA
PSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGL
IMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAP
TEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCR
NPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPG
VQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVA
APYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYH
GNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYT
RDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSY
RGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVR
WEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYST
TVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDPVAAPYCYTRDPSVRWEYCNL
TQCSDAEGTAVAPPTITPIPSLEAPSEQAPTEQRPGVQECYHGNGQSYQGTYFITVTGRT
CQAWSSMTPHSHSRTPAYYPNAGLIKNYCRNPDPVAAPWCYTTDPSVRWEYCNLTRCSDA
EWTAFVPPNVILAPSLEAFFEQALTEETPGVQDCYYHYGQSYRGTYSTTVTGRTCQAWSS
MTPHQHSRTPENYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCLVTESSVLA
TLTVVPDPSTEASSEEAPTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWH
QRTTEYYPNGGLTRNYCRNPDAEISPWCYTMDPNVRWEYCNLTQCPVTESSVLATSTAVS
EQAPTEQSPTVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTR
NYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCPVMESTLLTTPTVVPVPSTELPSEEAPTE
NSTGVQDCYRGDGQSYRGTLSTTITGRTCQSWSSMTPHWHRRIPLYYPNAGLTRNYCRNP
DAEIRPWCYTMDPSVRWEYCNLTRCPVTESSVLTTPTVAPVPSTEAPSEQAPPEKSPVVQ
DCYHGDGRSYRGISSTTVTGRTCQSWSSMIPHWHQRTPENYPNAGLTENYCRNPDSGKQP
WCYTTDPCVRWEYCNLTQCSETESGVLETPTVVPVPSMEAHSEAAPTEQTPVVRQCYHGN
GQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYPNDGLTMNYCRNPDADTGPWCFTMD
PSIRWEYCNLTRCSDTEGTVVAPPTVIQVPSLGPPSEQDCMFGNGKGYRGKKATTVTGTP
CQEWAAQEPHRHSTFIPGTNKWAGLEKNYCRNPDGDINGPWCYTMNPRKLFDYCDIPLCA
SSSFDCGKPQVEPKKCPGSIVGGCVAHPHSWPWQVSLRTRFGKHFCGGTLISPEWVLTAA
HCLKKSSRPSSYKVILGAHQEVNLESHVQEIEVSRLFLEPTQADIALLKLSRPAVITDKV
MPACLPSPDYMVTARTECYITGWGETQGTFGTGLLKEAQLLVIENEVCNHYKYICAEHLA
RGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYARVSRFVTWIEGMMRNN
NT seq 6123 nt   +upstreamnt  +downstreamnt
atggaacataaggaagtggttcttctacttcttttatttctgaaatcagcagcacctgag
caaagccatgtggtccaggattgctaccatggtgatggacagagttatcgaggcacgtac
tccaccactgtcacaggaaggacctgccaagcttggtcatctatgacaccacatcaacat
aataggaccacagaaaactacccaaatgctggcttgatcatgaactactgcaggaatcca
gatgctgtggcagctccttattgttatacgagggatcccggtgtcaggtgggagtactgc
aacctgacgcaatgctcagacgcagaagggactgccgtcgcgcctccgactgttaccccg
gttccaagcctagaggctccttccgaacaagcaccgactgagcaaaggcctggggtgcag
gagtgctaccatggtaatggacagagttatcgaggcacatactccaccactgtcacagga
agaacctgccaagcttggtcatctatgacaccacactcgcatagtcggaccccagaatac
tacccaaatgctggcttgatcatgaactactgcaggaatccagatgctgtggcagctcct
tattgttatacgagggatcccggtgtcaggtgggagtactgcaacctgacgcaatgctca
gacgcagaagggactgccgtcgcgcctccgactgttaccccggttccaagcctagaggct
ccttccgaacaagcaccgactgagcaaaggcctggggtgcaggagtgctaccatggtaat
ggacagagttatcgaggcacatactccaccactgtcacaggaagaacctgccaagcttgg
tcatctatgacaccacactcgcatagtcggaccccagaatactacccaaatgctggcttg
atcatgaactactgcaggaatccagatgctgtggcagctccttattgttatacgagggat
cccggtgtcaggtgggagtactgcaacctgacgcaatgctcagacgcagaagggactgcc
gtcgcgcctccgactgttaccccggttccaagcctagaggctccttccgaacaagcaccg
actgagcagaggcctggggtgcaggagtgctaccacggtaatggacagagttatcgaggc
acatactccaccactgtcactggaagaacctgccaagcttggtcatctatgacaccacac
tcgcatagtcggaccccagaatactacccaaatgctggcttgatcatgaactactgcagg
aatccagatgctgtggcagctccttattgttatacgagggatcccggtgtcaggtgggag
tactgcaacctgacgcaatgctcagacgcagaagggactgccgtcgcgcctccgactgtt
accccggttccaagcctagaggctccttccgaacaagcaccgactgagcaaaggcctggg
gtgcaggagtgctaccatggtaatggacagagttatcgaggcacatactccaccactgtc
acaggaagaacctgccaagcttggtcatctatgacaccacactcgcatagtcggacccca
gaatactacccaaatgctggcttgatcatgaactactgcaggaatccagatgctgtggca
gctccttattgttatacgagggatcccggtgtcaggtgggagtactgcaacctgacgcaa
tgctcagacgcagaagggactgccgtcgcgcctccgactgttaccccggttccaagccta
gaggctccttccgaacaagcaccgactgagcaaaggcctggggtgcaggagtgctaccat
ggtaatggacagagttatcgaggcacatactccaccactgtcacaggaagaacctgccaa
gcttggtcatctatgacaccacactcgcatagtcggaccccagaatactacccaaatgct
ggcttgatcatgaactactgcaggaatccagatgctgtggcagctccttattgttatacg
agggatcccggtgtcaggtgggagtactgcaacctgacgcaatgctcagacgcagaaggg
actgccgtcgcgcctccgactgttaccccggttccaagcctagaggctccttccgaacaa
gcaccgactgagcaaaggcctggggtgcaggagtgctaccatggtaatggacagagttat
cgaggcacatactccaccactgtcacaggaagaacctgccaagcttggtcatctatgaca
ccacactcgcatagtcggaccccagaatactacccaaatgctggcttgatcatgaactac
tgcaggaatccagatgctgtggcagctccttattgttatacgagggatcccggtgtcagg
tgggagtactgcaacctgacgcaatgctcagacgcagaagggactgccgtcgcgcctccg
actgttaccccggttccaagcctagaggctccttccgaacaagcaccgactgagcagagg
cctggggtgcaggagtgctaccacggtaatggacagagttatcgaggcacatactccacc
actgtcactggaagaacctgccaagcttggtcatctatgacaccacactcgcatagtcgg
accccagaatactacccaaatgctggcttgatcatgaactactgcaggaatccagatcct
gtggcagccccttattgttatacgagggatcccagtgtcaggtgggagtactgcaacctg
acacaatgctcagacgcagaagggactgccgtcgcgcctccaactattaccccgattcca
agcctagaggctccttctgaacaagcaccaactgagcaaaggcctggggtgcaggagtgc
taccacggaaatggacagagttatcaaggcacatacttcattactgtcacaggaagaacc
tgccaagcttggtcatctatgacaccacactcgcatagtcggaccccagcatactaccca
aatgctggcttgatcaagaactactgccgaaatccagatcctgtggcagccccttggtgt
tatacaacagatcccagtgtcaggtgggagtactgcaacctgacacgatgctcagatgca
gaatggactgccttcgtccctccgaatgttattctggctccaagcctagaggcttttttt
gaacaagcactgactgaggaaacccccggggtacaggactgctactaccattatggacag
agttaccgaggcacatactccaccactgtcacaggaagaacttgccaagcttggtcatct
atgacaccacaccagcatagtcggaccccagaaaactacccaaatgctggcctgaccagg
aactactgcaggaatccagatgctgagattcgcccttggtgttacaccatggatcccagt
gtcaggtgggagtactgcaacctgacacaatgcctggtgacagaatcaagtgtccttgca
actctcacggtggtcccagatccaagcacagaggcttcttctgaagaagcaccaacggag
caaagccccggggtccaggattgctaccatggtgatggacagagttatcgaggctcattc
tctaccactgtcacaggaaggacatgtcagtcttggtcctctatgacaccacactggcat
cagaggacaacagaatattatccaaatggtggcctgaccaggaactactgcaggaatcca
gatgctgagattagtccttggtgttataccatggatcccaatgtcagatgggagtactgc
aacctgacacaatgtccagtgacagaatcaagtgtccttgcgacgtccacggctgtttct
gaacaagcaccaacggagcaaagccccacagtccaggactgctaccatggtgatggacag
agttatcgaggctcattctccaccactgttacaggaaggacatgtcagtcttggtcctct
atgacaccacactggcatcagagaaccacagaatactacccaaatggtggcctgaccagg
aactactgcaggaatccagatgctgagattcgcccttggtgttataccatggatcccagt
gtcagatgggagtactgcaacctgacgcaatgtccagtgatggaatcaactctcctcaca
actcccacggtggtcccagttccaagcacagagcttccttctgaagaagcaccaactgaa
aacagcactggggtccaggactgctaccgaggtgatggacagagttatcgaggcacactc
tccaccactatcacaggaagaacatgtcagtcttggtcgtctatgacaccacattggcat
cggaggatcccattatactatccaaatgctggcctgaccaggaactactgcaggaatcca
gatgctgagattcgcccttggtgttacaccatggatcccagtgtcaggtgggagtactgc
aacctgacacgatgtccagtgacagaatcgagtgtcctcacaactcccacagtggccccg
gttccaagcacagaggctccttctgaacaagcaccacctgagaaaagccctgtggtccag
gattgctaccatggtgatggacggagttatcgaggcatatcctccaccactgtcacagga
aggacctgtcaatcttggtcatctatgataccacactggcatcagaggaccccagaaaac
tacccaaatgctggcctgaccgagaactactgcaggaatccagattctgggaaacaaccc
tggtgttacacaaccgatccgtgtgtgaggtgggagtactgcaatctgacacaatgctca
gaaacagaatcaggtgtcctagagactcccactgttgttccagttccaagcatggaggct
cattctgaagcagcaccaactgagcaaacccctgtggtccggcagtgctaccatggtaat
ggccagagttatcgaggcacattctccaccactgtcacaggaaggacatgtcaatcttgg
tcatccatgacaccacaccggcatcagaggaccccagaaaactacccaaatgatggcctg
acaatgaactactgcaggaatccagatgccgatacaggcccttggtgttttaccatggac
cccagcatcaggtgggagtactgcaacctgacgcgatgctcagacacagaagggactgtg
gtcgctcctccgactgtcatccaggttccaagcctagggcctccttctgaacaagactgt
atgtttgggaatgggaaaggataccggggcaagaaggcaaccactgttactgggacgcca
tgccaggaatgggctgcccaggagccccatagacacagcacgttcattccagggacaaat
aaatgggcaggtctggaaaaaaattactgccgtaaccctgatggtgacatcaatggtccc
tggtgctacacaatgaatccaagaaaactttttgactactgtgatatccctctctgtgca
tcctcttcatttgattgtgggaagcctcaagtggagccgaagaaatgtcctggaagcatt
gtaggggggtgtgtggcccacccacattcctggccctggcaagtcagtctcagaacaagg
tttggaaagcacttctgtggaggcaccttaatatccccagagtgggtgctgactgctgct
cactgcttgaagaagtcctcaaggccttcatcctacaaggtcatcctgggtgcacaccaa
gaagtgaacctcgaatctcatgttcaggaaatagaagtgtctaggctgttcttggagccc
acacaagcagatattgccttgctaaagctaagcaggcctgccgtcatcactgacaaagta
atgccagcttgtctgccatccccagactacatggtcaccgccaggactgaatgttacatc
actggctggggagaaacccaaggtacctttgggactggccttctcaaggaagcccagctc
cttgttattgagaatgaagtgtgcaatcactataagtatatttgtgctgagcatttggcc
agaggcactgacagttgccagggtgacagtggagggcctctggtttgcttcgagaaggac
aaatacattttacaaggagtcacttcttggggtcttggctgtgcacgccccaataagcct
ggtgtctatgctcgtgtttcaaggtttgttacttggattgagggaatgatgagaaataat
taa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (2)   
   OMIM (2)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (186)   
   KEGG ORTHOLOGY (1)   
   RefGene (178)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PROTHERM (2)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (5)   
   RefSeq(nuc) (1)   
   GenBank (2)   
   EMBL (2)   
3D Structure (13)   
   PDB (13)   
Protein domain (4)   
   Pfam (4)   
All databases (218)   

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