KEGG   Homo sapiens (human): 4144Help
Entry
4144              CDS       T01001                                 

Gene name
MAT2A, MATA2, MATII, SAMS2
Definition
(RefSeq) methionine adenosyltransferase 2A
  KO
K00789  S-adenosylmethionine synthetase [EC:2.5.1.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00270  Cysteine and methionine metabolism
hsa01100  Metabolic pathways
hsa01230  Biosynthesis of amino acids
Module
hsa_M00034  Methionine salvage pathway
hsa_M00035  Methionine degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Amino acid metabolism
   00270 Cysteine and methionine metabolism
    4144 (MAT2A)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.6  methionine adenosyltransferase
     4144 (MAT2A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: S-AdoMet_synt_C S-AdoMet_synt_M S-AdoMet_synt_N AdoMet_Synthase
Motif
Other DBs
NCBI-GeneID: 4144
NCBI-ProteinID: NP_005902
OMIM: 601468
HGNC: 6904
Ensembl: ENSG00000168906
Vega: OTTHUMG00000130174
Pharos: P31153(Tbio)
UniProt: P31153 A0A140VJP5
Structure
PDB: 

Jmol
Position
2p11.2
AA seq 395 aa AA seqDB search
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVA
KTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQG
VHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDS
KTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDT
IYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVI
VRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
NT seq 1188 nt NT seq  +upstreamnt  +downstreamnt
atgaacggacagctcaacggcttccacgaggcgttcatcgaggagggcacattccttttc
acctcagagtcggtcggggaaggccacccagataagatttgtgaccaaatcagtgatgct
gtccttgatgcccaccttcagcaggatcctgatgccaaagtagcttgtgaaactgttgct
aaaactggaatgatccttcttgctggggaaattacatccagagctgctgttgactaccag
aaagtggttcgtgaagctgttaaacacattggatatgatgattcttccaaaggttttgac
tacaagacttgtaacgtgctggtagccttggagcaacagtcaccagatattgctcaaggt
gttcatcttgacagaaatgaagaagacattggtgctggagaccagggcttaatgtttggc
tatgccactgatgaaactgaggagtgtatgcctttaaccattgtcttggcacacaagcta
aatgccaaactggcagaactacgccgtaatggcactttgccttggttacgccctgattct
aaaactcaagttactgtgcagtatatgcaggatcgaggtgctgtgcttcccatcagagtc
cacacaattgttatatctgttcagcatgatgaagaggtttgtcttgatgaaatgagggat
gccctaaaggagaaagtcatcaaagcagttgtgcctgcgaaataccttgatgaggataca
atctaccacctacagccaagtggcagatttgttattggtgggcctcagggtgatgctggt
ttgactggacgcaaaatcattgtggacacttatggcggttggggtgctcatggaggaggt
gccttttcaggaaaggattataccaaggtcgaccgttcagctgcttatgctgctcgttgg
gtggcaaaatcccttgttaaaggaggtctgtgccggagggttcttgttcaggtctcttat
gctattggagtttctcatccattatctatctccattttccattatggtacctctcagaag
agtgagagagagctattagagattgtgaagaagaatttcgatctccgccctggggtcatt
gtcagggatctggatctgaagaagccaatttatcagaggactgcagcctatggccacttt
ggtagggacagcttcccatgggaagtgcccaaaaagcttaaatattga

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