KEGG   Homo sapiens (human): 4216Help
Entry
4216              CDS       T01001                                 

Gene name
MAP3K4, MAPKKK4, MEKK_4, MEKK4, MTK1, PRO0412
Definition
mitogen-activated protein kinase kinase kinase 4 (EC:2.7.11.25)
Orthology
K04428  
mitogen-activated protein kinase kinase kinase 4 [EC:2.7.11.25]
Organism
hsa  Homo sapiens (human)
Pathway
MAPK signaling pathway
GnRH signaling pathway
Module
MAPK (JNK) signaling
MAPK (p38) signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    4216 (MAP3K4)
 Organismal Systems
  Endocrine system
   04912 GnRH signaling pathway
    4216 (MAP3K4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     4216 (MAP3K4)
Protein kinases [BR:hsa01001]
 Serine/threonine protein kinases: STE group
  STE11 family
   4216 (MAP3K4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Position
6q26
AA seq 1061 aa AA seqDB search
MYIGSIQKDRTTRSRDGACRSQFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVSWEELKAM
DLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQ
YYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLE
EEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTSADDSSAS
DEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDLLDVLKS
KQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYLLLTKHG
DRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRKAFQQSIE
GLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEVDESESVT
LQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKCESGRGT
RPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRN
SPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVAASRPSP
SGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPAYPRGDS
SGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQVCDTPKS
YDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKET
ADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQI
TIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAA
YMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP
ERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
NT seq 3186 nt NT seq  +upstreamnt  +downstreamnt
atgtacattggttccatccagaaagacaggacaactcgaagcagggatggggcttgcagg
tcacagttttctgaatttccagatcccatgtggggttcagattatgtgcagttgtcaagg
acaccaccttcatctgaggagaaatgcagtgctgtgtcgtgggaggagctgaaggccatg
gatttaccttcattcgaacctgccttcctagttctctgccgagtccttctgaatgtcata
catgagtgtctgaagttaagattggagcagagacctgctggagaaccatctctcttgagt
attaagcagctggtgagagagtgtaaggaggtcctgaagggcggcctgctgatgaagcag
tactaccagttcatgctgcaggaggttctggaggacttggagaagcccgactgcaacatt
gacgcttttgaagaggatctacataaaatgcttatggtgtattttgattacatgagaagc
tggatccaaatgctacagcaattacctcaagcatcgcatagtttaaaaaatctgttagaa
gaagaatggaatttcaccaaagaaataactcattacatacggggaggagaagcacaggcc
gggaagcttttctgtgacattgcaggaatgctgctgaaatctacaggaagttttttagaa
tttggcttacaggagagctgtgctgaattttggactagtgcggatgacagcagtgcttcc
gacgaaatcaggaggtctgttatagagatcagtcgagccctgaaggagctcttccatgaa
gccagagaaagggcttccaaagcacttggatttgctaaaatgttgagaaaggacctggaa
atagcagcagaattcaggctttcagccccagttagagacctcctggatgttctgaaatca
aaacagtatgtcaaggtgcaaattcctgggttagaaaacttgcaaatgtttgttccagac
actcttgctgaggagaagagtattattttgcagttactcaatgcagctgcaggaaaggac
tgttcaaaagattcagatgacgtactcatcgatgcctatctgcttctgaccaagcacggt
gatcgagcccgtgattcagaggacagctggggcacctgggaggcacagcctgtcaaagtc
gtgcctcaggtggagactgttgacaccctgagaagcatgcaggtggataatcttttacta
gttgtcatgcagtctgcgcatctcacaattcagagaaaagctttccagcagtccattgag
ggacttatgactctgtgccaggagcagacatccagtcagccggtcatcgccaaagctttg
cagcagctgaagaatgatgcattggagctatgcaacaggataagcaatgccattgaccgc
gtggaccacatgttcacatcagaatttgatgctgaggttgatgaatctgaatctgtcacc
ttgcaacagtactaccgagaagcaatgattcaggggtacaattttggatttgagtatcat
aaagaagttgttcgtttgatgtctggggagtttagacagaagataggagacaaatatata
agctttgcccggaagtggatgaattatgtcctgactaaatgtgagagtggtagaggtaca
agacccaggtgggcgactcaaggatttgattttctacaagcaattgaacctgcctttatt
tcagctttaccagaagatgacttcttgagtttacaagccttgatgaatgaatgcattggc
catgtcataggaaaaccacacagtcctgttacaggtttgtaccttgccattcatcggaac
agcccccgtcctatgaaggtacctcgatgccatagtgaccctcctaacccacacctcatt
atccccactccagagggattcagcactcggagcatgccttccgacgcgcggagccatggc
agccctgctgctgctgctgctgctgctgctgctgctgttgctgccagtcggcccagcccc
tctggtggtgactctgtgctgcccaaatccatcagcagtgcccatgataccaggggttcc
agcgttcctgaaaatgatcgattggcttccatagctgctgaattgcagtttaggtccctg
agtcgtcactcaagccccacggaggagcgagatgaaccagcatatccaagaggagattca
agtgggtccacaagaagaagttgggaacttcggacactaatcagccagagtaaagatact
gcttctaaactaggacccatagaagctatccagaagtcagtccgattgtttgaagaaaag
aggtaccgagaaatgaggagaaagaatatcattggtcaagtttgtgatacgcctaagtcc
tatgataatgttatgcacgttggcttgaggaaggtgaccttcaaatggcaaagaggaaac
aaaattggagaaggccagtatgggaaggtgtacacctgcatcagcgtcgacaccggggag
ctgatggccatgaaagagattcgatttcaacctaatgaccataagactatcaaggaaact
gcagacgaattgaaaatattcgaaggcatcaaacaccccaatctggttcggtattttggt
gtggagctccatagagaagaaatgtacatcttcatggagtactgcgatgaggggacttta
gaagaggtgtcaaggctgggacttcaggaacatgtgattaggctgtattcaaagcagatc
accattgcgatcaacgtcctccatgagcatggcatagtccaccgtgacattaaaggtgcc
aatatcttccttacctcatctggattaatcaaactgggagattttggatgttcagtaaag
ctcaaaaacaatgcccagaccatgcctggtgaagtgaacagcaccctggggacagcagca
tacatggcacctgaagtcatcactcgtgccaaaggagagggccatgggcgtgcggccgac
atctggagtctggggtgtgttgtcatagagatggtgactggcaagaggccttggcatgag
tatgagcacaactttcaaattatgtataaagtggggatgggacataagccaccaatccct
gaaagattaagccctgaaggaaaggacttcctttctcactgccttgagagtgacccaaag
atgagatggaccgccagccagctcctcgaccattcgtttgtcaaggtttgcacagatgaa
gaatga

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