KEGG T01001: 4306

Homo sapiens (human): 4306

Entry

4306 CDS T01001

Gene name

NR3C2, MCR, MLR, MR, NR3C2VIT

Definition

nuclear receptor subfamily 3, group C, member 2

Orthology

K08555

mineralocorticoid receptor

Organism

hsa Homo sapiens (human)

Pathway

hsa04960

Aldosterone-regulated sodium reabsorption

Disease

H00243	Hyperkalemic distal renal tubular acidosis (RTA type 4)
H00603	Hypertension exacerbated in pregnancy

Drug target

Spironolactone:

D00443

Potassium canrenoate:

Canrenone:

Eplerenone:

Desoxycortone:

Other:

D03792 D03917 D05020 D05640

Class

Organismal Systems; Excretory system; Aldosterone-regulated sodium reabsorption [PATH:hsa04960]

SSDB

Motif

Pfam:

zf-C4 Hormone_recep

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

3VHV 2AAX 2AB2 2AA2 2AA6 2A3I 1Y9R 3VHU 2AA5 2AA7 2OAX 2ABI 1YA3

Position

4q31.1

AA seq 984 aa
METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST
QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE
QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAV
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN
VENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP
ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD
SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF
DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR
DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS
KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL
QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN
TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV
VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML
VEIISDQLPKVESGNAKPLYFHRK

NT seq 2955 nt +upstreamnt +downstreamnt
atggagaccaaaggctaccacagtctccctgaaggtctagatatggaaagacggtggggt
caagtttctcaggctgtggagcgttcttccctgggacctacagagaggaccgatgagaat
aactacatggagattgtcaacgtaagctgtgtttccggtgctattccaaacaacagtact
caaggaagcagcaaagaaaaacaagaactactcccttgccttcagcaagacaataatcgg
cctgggattttaacatctgatattaaaactgagctggaatctaaggaactttcagcaact
gtagctgagtccatgggtttatatatggattctgtaagagatgctgactattcctatgag
cagcagaaccaacaaggaagcatgagtccagctaagatttatcagaatgttgaacagctg
gtgaaattttacaaaggaaatggccatcgtccttccactctaagttgtgtgaacacgccc
ttgagatcatttatgtctgactctgggagctccgtgaatggtggcgtcatgcgcgccgtt
gttaaaagccctatcatgtgtcatgagaaaagcccgtctgtttgcagccctctgaacatg
acatcttcggtttgcagccctgctggaatcaactctgtgtcctccaccacagccagcttt
ggcagttttccagtgcacagcccaatcacccagggaactcctctgacatgctcccctaat
gttgaaaatcgaggctccaggtcgcacagccctgcacatgctagcaatgtgggctctcct
ctctcaagtccgttaagtagcatgaaatcctcaatttccagccctccaagtcactgcagt
gtaaaatctccagtctccagtcccaataatgtcactctgagatcctctgtgtctagccct
gcaaatattaacaactcaaggtgctctgtttccagcccttcgaacactaataacagatcc
acgctttccagtccggcagccagtactgtgggatctatctgtagccctgtaaacaatgcc
ttcagctacactgcttctggcacctctgctggatccagtacattgcgggatgtggttccc
agtccagacacgcaggagaaaggtgctcaagaggtcccttttcctaagactgaggaagta
gagagtgccatctcaaatggtgtgactggccagcttaatattgtccagtacataaaacca
gaaccagatggagcttttagcagctcatgtctaggaggaaatagcaaaataaattcggat
tcttcattctcagtaccaataaagcaagaatcaaccaagcattcatgttcaggcacctct
tttaaagggaatccaacagtaaacccgtttccatttatggatggctcgtatttttccttt
atggatgataaagactattattccctatcaggaattttaggaccacctgtgcccggcttt
gatggtaactgtgaaggcagcggattcccagtgggtattaaacaagaaccagatgatggg
agctattacccagaggccagcatcccttcctctgctattgttggggtgaattcaggtgga
cagtccttccactacaggattggtgctcaaggtacaatatctttatcacgatcggctaga
gaccaatctttccaacacctgagttcctttcctcctgtcaatactttagtggagtcatgg
aaatcacacggcgacctgtcgtctagaagaagtgatgggtatccggtcttagaatacatt
ccagaaaatgtatcaagctctactttacgaagtgtttctactggatcttcaagaccttca
aaaatatgtttggtgtgtggggatgaggcttcaggatgccattatggggtagtcacctgt
ggcagctgcaaagttttcttcaaaagagcagtggaagggcaacacaactatttatgtgct
ggaagaaatgattgcatcattgataagattcgacgaaagaattgtcctgcttgcagactt
cagaaatgtcttcaagctggaatgaatttaggagcacgaaagtcaaagaagttgggaaag
ttaaaagggattcacgaggagcagccacagcagcagcagcccccacccccacccccaccc
ccgcaaagcccagaggaagggacaacgtacatcgctcctgcaaaagaaccctcggtcaac
acagcactggttcctcagctctccacaatctcacgagcgctcacaccttcccccgttatg
gtccttgaaaacattgaacctgaaattgtatatgcaggctatgacagctcaaaaccagat
acagccgaaaatctgctctccacgctcaaccgcttagcaggcaaacagatgatccaagtc
gtgaagtgggcaaaggtacttccaggatttaaaaacttgcctcttgaggaccaaattacc
ctaatccagtattcttggatgtgtctatcatcatttgccttgagctggagatcgtacaaa
catacgaacagccaatttctctattttgcaccagacctagtctttaatgaagagaagatg
catcagtctgccatgtatgaactatgccaggggatgcaccaaatcagccttcagttcgtt
cgactgcagctcacctttgaagaatacaccatcatgaaagttttgctgctactaagcaca
attccaaaggatggcctcaaaagccaggctgcatttgaagaaatgaggacaaattacatc
aaagaactgaggaagatggtaactaagtgtcccaacaattctgggcagagctggcagagg
ttctaccaactgaccaagctgctggactccatgcatgacctggtgagcgacctgctggaa
ttctgcttctacaccttccgagagtcccatgcgctgaaggtagagttccccgcaatgctg
gtggagatcatcagcgaccagctgcccaaggtggagtcggggaacgccaagccgctctac
ttccaccggaagtga

All links

Ontology (5)   
   KEGG BRITE (5)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Drug (11)   
   KEGG DRUG (11)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (7)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (2)   
   RefSeq(pep) (2)   
DNA sequence (22)   
   RefSeq(nuc) (2)   
   GenBank (10)   
   EMBL (10)   
3D Structure (13)   
   PDB (13)   
Protein domain (2)   
   Pfam (2)   
All databases (79)   

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