KEGG   Homo sapiens (human): 4540Help
Entry
4540              CDS       T01001                                 

Gene name
ND5, MTND5, MT-ND5
Definition
(RefSeq) NADH dehydrogenase, subunit 5 (complex I)
  KO
K03883  
NADH-ubiquinone oxidoreductase chain 5 [EC:1.6.5.3]
Organism
hsa  Homo sapiens (human)
Pathway
Oxidative phosphorylation
Metabolic pathways
Thermogenesis
Retrograde endocannabinoid signaling
Parkinson's disease
Module
NADH:ubiquinone oxidoreductase, mitochondria
Disease
H00068  
Leber hereditary optic atrophy (LHON)
H00473  
Mitochondrial respiratory chain deficiencies (MRCD)
H01347  
MELAS Syndrome
H01355  
Kearns-Sayre syndrome
H01356  
Myoclonic Epilepsy and Ragged-Red Fiber Disease
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Energy metabolism
   00190 Oxidative phosphorylation
    4540 (ND5)
 Organismal Systems
  Nervous system
   04723 Retrograde endocannabinoid signaling
    4540 (ND5)
  Environmental adaptation
   04714 Thermogenesis
    4540 (ND5)
 Human Diseases
  Neurodegenerative diseases
   05012 Parkinson's disease
    4540 (ND5)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.6  Acting on NADH or NADPH
   1.6.5  With a quinone or similar compound as acceptor
    1.6.5.3  NADH:ubiquinone reductase (H+-translocating)
     4540 (ND5)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA-encoded proteins
   Mitochondrial respiratory chain complex I
    4540 (ND5)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Pharos: 
P03915(Tclin)
UniProt: 
Structure
PDB: 

Jmol
Position
MT
AA seq 603 aa AA seqDB search
MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQE
VIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKY
LLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDI
GFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGP
TPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKK
IVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMG
GLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTS
AYSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQT
TIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYL
GLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLL
LIT
NT seq 1812 nt NT seq  +upstreamnt  +downstreamnt
ataaccatgcacactactataaccaccctaaccctgacttccctaattccccccatcctt
accaccctcgttaaccctaacaaaaaaaactcatacccccattatgtaaaatccattgtc
gcatccacctttattatcagtctcttccccacaacaatattcatgtgcctagaccaagaa
gttattatctcgaactgacactgagccacaacccaaacaacccagctctccctaagcttc
aaactagactacttctccataatattcatccctgtagcattgttcgttacatggtccatc
atagaattctcactgtgatatataaactcagacccaaacattaatcagttcttcaaatat
ctactcatcttcctaattaccatactaatcttagttaccgctaacaacctattccaactg
ttcatcggctgagagggcgtaggaattatatccttcttgctcatcagttgatgatacgcc
cgagcagatgccaacacagcagccattcaagcaatcctatacaaccgtatcggcgatatc
ggtttcatcctcgccttagcatgatttatcctacactccaactcatgagacccacaacaa
atagcccttctaaacgctaatccaagcctcaccccactactaggcctcctcctagcagca
gcaggcaaatcagcccaattaggtctccacccctgactcccctcagccatagaaggcccc
accccagtctcagccctactccactcaagcactatagttgtagcaggaatcttcttactc
atccgcttccaccccctagcagaaaatagcccactaatccaaactctaacactatgctta
ggcgctatcaccactctgttcgcagcagtctgcgcccttacacaaaatgacatcaaaaaa
atcgtagccttctccacttcaagtcaactaggactcataatagttacaatcggcatcaac
caaccacacctagcattcctgcacatctgtacccacgccttcttcaaagccatactattt
atgtgctccgggtccatcatccacaaccttaacaatgaacaagatattcgaaaaatagga
ggactactcaaaaccatacctctcacttcaacctccctcaccattggcagcctagcatta
gcaggaatacctttcctcacaggtttctactccaaagaccacatcatcgaaaccgcaaac
atatcatacacaaacgcctgagccctatctattactctcatcgctacctccctgacaagc
gcctatagcactcgaataattcttctcaccctaacaggtcaacctcgcttccccaccctt
actaacattaacgaaaataaccccaccctactaaaccccattaaacgcctggcagccgga
agcctattcgcaggatttctcattactaacaacatttcccccgcatcccccttccaaaca
acaatccccctctacctaaaactcacagccctcgctgtcactttcctaggacttctaaca
gccctagacctcaactacctaaccaacaaacttaaaataaaatccccactatgcacattt
tatttctccaacatactcggattctaccctagcatcacacaccgcacaatcccctatcta
ggccttcttacgagccaaaacctgcccctactcctcctagacctaacctgactagaaaag
ctattacctaaaacaatttcacagcaccaaatctccacctccatcatcacctcaacccaa
aaaggcataattaaactttacttcctctctttcttcttcccactcatcctaaccctactc
ctaatcacataa

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