KEGG H.sapiens: 47

Homo sapiens (human): 47

Entry

47 CDS H.sapiens

Gene name ACLY

Definition ATP citrate lyase (EC:2.3.3.8)

Orthology K01648 ATP citrate (pro-S)-lyase [EC:2.3.3.8]

Pathway hsa00020 Citrate cycle (TCA cycle)
hsa01100 Metabolic pathways

Class Metabolism; Carbohydrate Metabolism; Citrate cycle (TCA cycle)
[PATH:hsa00020]

SSDB

Motif Pfam: Citrate_synt Ligase_CoA CoA_binding ATP-grasp_2
PROSITE: SUCCINYL_COA_LIG_3 SUCCINYL_COA_LIG_1 SUCCINYL_COA_LIG_2

Other DBs NCBI-GI: 38569421
NCBI-GeneID: 47
OMIM: 108728
HGNC: 115
HPRD: 00155
Ensembl: ENSG00000131473
UniProt: P53396

Position 17q12-q21

AA seq 1101 aa
MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPD
QLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFY
VCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEI
LASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPP
PFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNE
LANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRA
IRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALG
HRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVP
SPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQK
FYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEG
IPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYV
SRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIG
GTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALK
EAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASF
MTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADH
GPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFV
NKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPN
LILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLK
QGLYRHPWDDISYVLPEHMSM

NT seq 3306 nt +upstreamnt +downstreamnt
atgtcggccaaggcaatttcagagcagacgggcaaagaactcctttacaagttcatctgt
accacctcagccatccagaatcggttcaagtatgctcgggtcactcctgacacagactgg
gcccgcttgctgcaggaccacccctggctgctcagccagaacttggtagtcaagccagac
cagctgatcaaacgtcgtggaaaacttggtctcgttggggtcaacctcactctggatggg
gtcaagtcctggctgaagccacggctgggacaggaagccacagttggcaaggccacaggc
ttcctcaagaactttctgatcgagcccttcgtcccccacagtcaggctgaggagttctat
gtctgcatctatgccacccgagaaggggactacgtcctgttccaccacgaggggggtgtg
gacgtgggtgatgtggacgccaaggcccagaagctgcttgttggcgtggatgagaaactg
aatcctgaggacatcaaaaaacacctgttggtccacgcccctgaagacaagaaagaaatt
ctggccagttttatctccggcctcttcaatttctacgaggacttgtacttcacctacctc
gagatcaatccccttgtagtgaccaaagatggagtctatgtccttgacttggcggccaag
gtggacgccactgccgactacatctgcaaagtgaagtggggtgacatcgagttccctccc
cccttcgggcgggaggcatatccagaggaagcctacattgcagacctcgatgccaaaagt
ggggcaagcctgaagctgaccttgctgaaccccaaagggaggatctggaccatggtggcc
gggggtggcgcctctgtcgtgtacagcgataccatctgtgatctagggggtgtcaacgag
ctggcaaactatggggagtactcaggcgcccccagcgagcagcagacctatgactatgcc
aagactatcctctccctcatgacccgagagaagcacccagatggcaagatcctcatcatt
ggaggcagcatcgcaaacttcaccaacgtggctgccacgttcaagggcatcgtgagagca
attcgagattaccagggccccctgaaggagcacgaagtcacaatctttgtccgaagaggt
ggccccaactatcaggagggcttacgggtgatgggagaagtcgggaagaccactgggatc
cccatccatgtctttggcacagagactcacatgacggccattgtgggcatggccctgggc
caccggcccatccccaaccagccacccacagcggcccacactgcaaacttcctcctcaac
gccagcgggagcacatcgacgccagcccccagcaggacagcatctttttctgagtccagg
gccgatgaggtggcgcctgcaaagaaggccaagcctgccatgccacaagattcagtccca
agtccaagatccctgcaaggaaagagcaccaccctcttcagccgccacaccaaggccatt
gtgtggggcatgcagacccgggccgtgcaaggcatgctggactttgactatgtctgctcc
cgagacgagccctcagtggctgccatggtctaccctttcactggggaccacaagcagaag
ttttactgggggcacaaagagatcctgatccctgtcttcaagaacatggctgatgccatg
aggaagcatccggaggtagatgtgctcatcaactttgcctctctccgctctgcctatgac
agcaccatggagaccatgaactatgcccagatccggaccatcgccatcatagctgaaggc
atccctgaggccctcacgagaaagctgatcaagaaggcggaccagaagggagtgaccatc
atcggacctgccactgttggaggcatcaagcctgggtgctttaagattggcaacacaggt
gggatgctggacaacatcctggcctccaaactgtaccgcccaggcagcgtggcctatgtc
tcacgttccggaggcatgtccaacgagctcaacaatatcatctctcggaccacggatggc
gtctatgagggcgtggccattggtggggacaggtacccgggctccacattcatggatcat
gtgttacgctatcaggacactccaggagtcaaaatgattgtggttcttggagagattggg
ggcactgaggaatataagatttgccggggcatcaaggagggccgcctcactaagcccatc
gtctgctggtgcatcgggacgtgtgccaccatgttctcctctgaggtccagtttggccat
gctggagcttgtgccaaccaggcttctgaaactgcagtagccaagaaccaggctttgaag
gaagcaggagtgtttgtgccccggagctttgatgagcttggagagatcatccagtctgta
tacgaagatctcgtggccaatggagtcattgtacctgcccaggaggtgccgcccccaacc
gtgcccatggactactcctgggccagggagcttggtttgatccgcaaacctgcctcgttc
atgaccagcatctgcgatgagcgaggacaggagctcatctacgcgggcatgcccatcact
gaggtcttcaaggaagagatgggcattggcggggtcctcggcctcctctggttccagaaa
aggttgcctaagtactcttgccagttcattgagatgtgtctgatggtgacagctgatcac
gggccagccgtctctggagcccacaacaccatcatttgtgcgcgagctgggaaagacctg
gtctccagcctcacctcggggctgctcaccatcggggatcggtttgggggtgccttggat
gcagcagccaagatgttcagtaaagcctttgacagtggcattatccccatggagtttgtg
aacaagatgaagaaggaagggaagctgatcatgggcattggtcaccgagtgaagtcgata
aacaacccagacatgcgagtgcagatcctcaaagattacgtcaggcagcacttccctgcc
actcctctgctcgattatgcactggaagtagagaagattaccacctcgaagaagccaaat
cttatcctgaatgtagatggtctcatcggagtcgcatttgtagacatgcttagaaactgt
gggtcctttactcgggaggaagctgatgaatatattgacattggagccctcaatggcatc
tttgtgctgggaaggagtatggggttcattggacactatcttgatcagaagaggctgaag
caggggctgtatcgtcatccgtgggatgatatttcatatgttcttccggaacacatgagc
atgtaa

All links

Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (6)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (6)   
   UniProt (1)   
   RefSeq(pep) (2)   
   IPI (3)   
DNA sequence (6)   
   RefSeq(nuc) (2)   
   GenBank (2)   
   EMBL (2)   
Protein domain (7)   
   Pfam (4)   
   PROSITE (3)   
All databases (36)

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