KEGG   Homo sapiens (human): 4718
Entry
4718              CDS       T01001                                 
Symbol
NDUFC2, B14.5b, CI-B14.5b, HLC-1, MC1DN36, NADHDH2
Name
(RefSeq) NADH:ubiquinone oxidoreductase subunit C2
  KO
K03968  NADH dehydrogenase (ubiquinone) 1 subunit C2
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04714  Thermogenesis
hsa04723  Retrograde endocannabinoid signaling
hsa04932  Non-alcoholic fatty liver disease
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
Module
hsa_M00147  NADH dehydrogenase (ubiquinone) 1 beta subcomplex
Network
nt06460  Alzheimer disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06529  Thermogenesis
  Element
N00995  Electron transfer in Complex I
N00997  Mutation-caused aberrant Abeta to electron transfer in Complex I
N01042  Mutation-caused aberrant SNCA to electron transfer in Complex I
N01043  Mutation-inactivated PINK1 to electron transfer in Complex I
N01044  MPP+ to electron transfer in Complex I
N01045  Rotenone to electron transfer in Complex I
N01136  Mutation-caused aberrant TDP43 to electron transfer in Complex I
N01691  mitochondrial complex - UCP1 in Thermogenesis
Disease
H00473  Mitochondrial complex I deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    4718 (NDUFC2)
 09150 Organismal Systems
  09156 Nervous system
   04723 Retrograde endocannabinoid signaling
    4718 (NDUFC2)
  09159 Environmental adaptation
   04714 Thermogenesis
    4718 (NDUFC2)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    4718 (NDUFC2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4718 (NDUFC2)
   05012 Parkinson disease
    4718 (NDUFC2)
   05014 Amyotrophic lateral sclerosis
    4718 (NDUFC2)
   05016 Huntington disease
    4718 (NDUFC2)
   05020 Prion disease
    4718 (NDUFC2)
   05022 Pathways of neurodegeneration - multiple diseases
    4718 (NDUFC2)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    4718 (NDUFC2)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    4718 (NDUFC2)
SSDB
Motif
Pfam: NDUF_C2 HL_N-beta
Other DBs
NCBI-GeneID: 4718
NCBI-ProteinID: NP_004540
OMIM: 603845
HGNC: 7706
Ensembl: ENSG00000151366
UniProt: O95298
Structure
Position
11:complement(78068297..78079862)
AA seq 119 aa
MIARRNPEPLRFLPDEARSLPPPKLTDPRLLYIGFLGYCSGLIDNLIRRRPIATAGLHRQ
LLYITAFFFAGYYLVKREDYLYAVRDREMFGYMKLHPEDFPEEDKKTYGEIFEKFHPIR
NT seq 360 nt   +upstreamnt  +downstreamnt
atgatcgcacggcggaacccagaacccttacggtttctgccggatgaggcccggagcctg
cccccgcccaagctgaccgacccgcggctcctctacatcggcttcttgggctactgctcc
ggcctgattgataacctaatccggcggaggccgatcgcgacggctggtttgcatcgccag
cttctatatattacggcctttttttttgctggatattatcttgtaaaacgtgaagactac
ctgtatgctgtgagggaccgtgaaatgtttggatatatgaaattacatccagaggatttt
cctgaagaagataagaaaacatatggtgaaatttttgaaaaattccatccaatacgttga

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (14)   
   KEGG PATHWAY (13)   
   KEGG MODULE (1)   
Network (13)   
   KEGG NETWORK (13)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (29)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (17)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (31)   
   RefSeq(nuc) (3)   
   GenBank (14)   
   EMBL (14)   
3D Structure (4)   
   PDB (4)   
Protein domain (2)   
   Pfam (2)   
All databases (103)   

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