KEGG T01001: 48

Homo sapiens (human): 48

Entry

48 CDS T01001

Gene name

ACO1, ACONS, IREB1, IREBP, IREBP1, IRP1

Definition

aconitase 1, soluble (EC:4.2.1.3)

Orthology

K01681

aconitate hydratase 1 / homoaconitase [EC:4.2.1.3 4.2.1.-]

Organism

hsa Homo sapiens (human)

Pathway

hsa00020	Citrate cycle (TCA cycle)
hsa00300	Lysine biosynthesis
hsa00630	Glyoxylate and dicarboxylate metabolism
hsa01100	Metabolic pathways
hsa01210	2-Oxocarboxylic acid metabolism
hsa01230	Biosynthesis of amino acids

Module

hsa_M00010

Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate

Class

Metabolism; Carbohydrate metabolism; Citrate cycle (TCA cycle) [PATH:hsa00020]
Metabolism; Carbohydrate metabolism; Glyoxylate and dicarboxylate metabolism [PATH:hsa00630]
Metabolism; Amino acid metabolism; Lysine biosynthesis [PATH:hsa00300]

SSDB

Motif

Pfam:

Aconitase Aconitase_C

Other DBs

NCBI-GI:

8659555

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

2B3Y 2B3X

Position

9p21.1

AA seq 889 aa
MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDI
ENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPA
DLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQV
NLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLP
QVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMC
PEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVE
LDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNT
EFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTY
YLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEG
RVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVE
RQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPK
SIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMA
RGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSR
DWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIP
ENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK

NT seq 2670 nt +upstreamnt +downstreamnt
atgagcaacccattcgcacaccttgctgagccattggatcctgtacaaccaggaaagaaa
ttcttcaatttgaataaattggaggattcaagatatgggcgcttaccattttcgatcaga
gttcttctggaagcagccattcggaattgtgatgagtttttggtgaagaaacaggatatt
gaaaatattctacattggaatgtcacgcagcacaagaacatagaagtgccatttaagcct
gctcgtgtcatcctgcaggactttacgggtgtgcccgctgtggttgactttgctgcaatg
cgtgatgctgtgaaaaagttaggaggagatccagagaaaataaaccctgtctgccctgct
gatcttgtaatagatcattccatccaggttgatttcaacagaagggcagacagtttacag
aagaatcaagacctggaatttgaaagaaatagagagcgatttgaatttttaaagtggggt
tcccaggcttttcacaacatgcggattattccccctggctcaggaatcatccaccaggtg
aatttggaatatttggcaagagtggtatttgatcaggatggatattattacccagacagc
ctcgtgggcacagactcgcacactaccatgattgatggcttgggcattcttggttggggt
gtcggtggtattgaagcagaagctgtcatgctgggtcagccaatcagtatggtgcttcct
caggtgattggctacaggctgatggggaagccccaccctctggtaacatccactgacatc
gtgctcaccattaccaagcacctccgccaggttggggtagtgggcaaatttgtcgagttc
ttcgggcctggagtagcccagttgtccattgctgaccgagctacgattgctaacatgtgt
ccagagtacggagcaactgctgcctttttcccagttgatgaagttagtatcacgtacctg
gtgcaaacaggtcgtgatgaagaaaaattaaagtatattaaaaaatatcttcaggctgta
ggaatgtttcgagatttcaatgacccttctcaagacccagacttcacccaggttgtggaa
ttagatttgaaaacagtagtgccttgctgtagtggacccaaaaggcctcaggacaaagtt
gctgtgtccgacatgaaaaaggactttgagagctgccttggagccaagcaaggatttaaa
ggattccaagttgctcctgaacatcataatgaccataagacctttatctatgataacact
gaattcacccttgctcatggttctgtggtcattgctgccattactagctgcacaaacacc
agtaatccgtctgtgatgttaggggcaggattgttagcaaagaaagctgtggatgctggc
ctgaacgtgatgccttacatcaaaactagcctgtctcctgggagtggcgtggtcacctac
tacctacaagaaagcggagtcatgccttatctgtctcagcttgggtttgacgtggtgggc
tatggctgcatgacctgcattggcaacagtgggcctttacctgaacctgtggtagaagcc
atcacacagggagaccttgtagctgttggagtactatctggaaacaggaattttgaaggt
cgagttcaccccaacacccgggccaactatttagcctctccccccttagtaatagcatat
gcaattgctggaaccatcagaatcgactttgagaaagagccattgggagtaaatgcaaag
ggacagcaggtatttctgaaagatatctggccgactagagacgagatccaggcagtggag
cgtcagtatgtcatcccggggatgtttaaggaagtctatcagaaaatagagactgtgaat
gaaagctggaatgccttagcaaccccatcagataagctgtttttctggaattccaaatct
acgtatatcaaatcaccaccattctttgaaaacctgactttggatcttcagccccctaaa
tctatagtggatgcctatgtgctgctaaatttgggagattcggtaacaactgaccacatc
tccccagctggaaatattgcaagaaacagtcctgctgctcgctacttaactaacagaggc
ctaactccacgagaattcaactcctatggctcccgccgaggtaatgacgccgtcatggca
cggggaacatttgccaacattcgcttgttaaacagatttttgaacaagcaggcaccacag
actatccatctgccttctggggaaatccttgatgtgtttgatgctgctgagcggtaccag
caggcaggccttcccctgatcgttctggctggcaaagagtacggtgcaggcagctcccga
gactgggcagctaagggccctttcctgctgggaatcaaagccgtcctggccgagagctac
gagcgcattcaccgcagtaacctggttgggatgggtgtgatcccacttgaatatctccct
ggtgagaatgcagatgccctggggctcacagggcaagaacgatacactatcattattcca
gaaaacctcaaaccacaaatgaaagtccaggtcaagctggatactggcaagaccttccag
gctgtcatgaggtttgacactgatgtggagctcacttatttcctcaacgggggcatcctc
aactacatgatccgcaagatggccaagtag

All links

Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Disease (1)   
   OMIM (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (6)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (17)   
   RefSeq(nuc) (1)   
   GenBank (8)   
   EMBL (8)   
3D Structure (2)   
   PDB (2)   
Protein domain (2)   
   Pfam (2)   
All databases (57)   

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