KEGG   Homo sapiens (human): 5063Help
Entry
5063              CDS       T01001                                 
Gene name
PAK3, CDKN1A, MRX30, MRX47, OPHN3, PAK3beta, bPAK, hPAK3
Definition
p21 protein (Cdc42/Rac)-activated kinase 3 (EC:2.7.11.1)
Orthology
K05733  
p21-activated kinase 3 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
ErbB signaling pathway
Axon guidance
Focal adhesion
T cell receptor signaling pathway
Regulation of actin cytoskeleton
Renal cell carcinoma
Disease
H00480  
Non-syndromic X-linked mental retardation
Class
Environmental Information Processing; Signal transduction; ErbB signaling pathway [PATH:hsa04012]
Cellular Processes; Cell motility; Regulation of actin cytoskeleton [PATH:hsa04810]
Cellular Processes; Cell communication; Focal adhesion [PATH:hsa04510]
Organismal Systems; Immune system; T cell receptor signaling pathway [PATH:hsa04660]
Organismal Systems; Development; Axon guidance [PATH:hsa04360]
Human Diseases; Cancers; Renal cell carcinoma [PATH:hsa05211]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
Xq23
AA seq 544 aa AA seqDB search
MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN
KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVL
DVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEE
EEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQ
RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN
LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD
EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS
TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP
ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIK
NSSR
NT seq 1635 nt NT seq  +upstreamnt  +downstreamnt
atgtctgacggtctggataatgaagagaaacccccggctcctccactgaggatgaatagt
aacaaccgggattcttcagcactcaaccacagctccaaaccacttcccatggcccctgaa
gagaagaataagaaagccaggcttcgctctatcttcccaggaggaggggataaaaccaat
aagaagaaggagaaagagcgcccagagatctctcttccttcagactttgagcatacgatt
catgtggggtttgatgcagtcaccggggaattcactggaattccagagcaatgggcacga
ttactccaaacttccaacataacaaaattggaacagaagaagaacccacaagctgttcta
gatgttctcaaattctatgattccaaagaaacagtcaacaaccagaaatacatgagcttt
acatcaggagataaaagtgcacatggatacatagcagcccatccttcgagtacaaaaaca
gcatctgagcctccattggcccctcctgtgtctgaagaagaagatgaagaggaagaagaa
gaagaagatgaaaatgagccaccaccagttatcgcaccaagaccagagcatacaaaatca
atctatactcgttctgtggttgaatccattgcttcaccagcagtaccaaataaagaggtc
acaccaccctctgctgaaaatgccaattccagtactttgtacaggaacacagatcggcaa
agaaaaaaatccaagatgacagatgaggagatcttagagaagctaagaagcattgtgagt
gttggggacccaaagaaaaaatacacaagatttgaaaaaattggtcaaggggcatcaggt
actgtttatacagcactagacattgcaacaggacaagaggtggccataaagcagatgaac
cttcaacagcaacccaagaaggaattaattattaatgaaattctggtcatgagggaaaat
aagaaccctaatattgttaattatttagatagctacttggtgggtgatgaactatgggta
gtcatggaatacttggctggtggctctctgactgatgtggtcacagagacctgtatggat
gaaggacagatagcagctgtctgcagagagtgcctgcaagctttggatttcctgcactca
aaccaggtgatccatagagatataaagagtgacaatattcttctcgggatggatggctct
gttaaattgactgactttgggttctgtgcccagatcactcctgagcaaagtaaacgaagc
actatggtgggaaccccatattggatggcacctgaggtggtgactcgaaaagcttatggt
ccgaaagttgatatctggtctcttggaattatggcaattgaaatggtggaaggtgaaccc
ccttaccttaatgaaaatccactcagggcattgtatctgatagccactaatggaactcca
gagctccagaatcctgagagactgtcagctgtattccgtgactttttaaatcgctgtctt
gagatggatgtggataggcgaggatctgccaaggagcttttgcagcatccatttttaaaa
ttagccaagcctctctccagcctgactcctctgattatcgctgcaaaggaagcaattaag
aacagcagccgctaa
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