KEGG   Homo sapiens (human): 5087
Entry
5087              CDS       T01001                                 
Symbol
PBX1, CAKUHED
Name
(RefSeq) PBX homeobox 1
  KO
K09355  pre-B-cell leukemia transcription factor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04148  Efferocytosis
hsa04927  Cortisol synthesis and secretion
hsa04934  Cushing syndrome
hsa05202  Transcriptional misregulation in cancer
Network
nt06240  Transcription (cancer)
nt06310  CRH-ACTH-cortisol signaling
nt06360  Cushing syndrome
nt06535  Efferocytosis
  Element
N00117  E2A-PBX1 fusion to transcriptional activation
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N01778  Production of IL10 via the Sirtuin1 signaling cascade
Disease
H00001  B-cell acute lymphoblastic leukemia
H01867  Congenital anomalies of kidney and urinary tract
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    5087 (PBX1)
 09150 Organismal Systems
  09152 Endocrine system
   04927 Cortisol synthesis and secretion
    5087 (PBX1)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    5087 (PBX1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    5087 (PBX1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    5087 (PBX1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Helix-turn-helix
   Homeo domain TALE
    5087 (PBX1)
SSDB
Motif
Pfam: PBC Homeobox_KN Homeodomain YdaS_toxin HTH_3 UCH LZ3wCH EF-hand_2
Other DBs
NCBI-GeneID: 5087
NCBI-ProteinID: NP_002576
OMIM: 176310
HGNC: 8632
Ensembl: ENSG00000185630
UniProt: P40424 A8K5V0
Structure
Position
1:164559184..164886047
AA seq 430 aa
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDE
AQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGP
EKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVM
NLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNF
NKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQE
EANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQG
AQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEG
PGSVHSDTSN
NT seq 1293 nt   +upstreamnt  +downstreamnt
atggacgagcagcccaggctgatgcattcccatgctggggtcgggatggccggacacccc
ggcctgtcccagcacttgcaggatggggccggagggaccgagggggagggcgggaggaag
caggacattggagacattttacagcaaattatgaccatcacagaccagagtttggatgag
gcgcaggccagaaaacatgctttaaactgccacagaatgaagcctgccttgtttaatgtg
ttgtgtgaaatcaaagaaaaaacagttttgagtatccgaggagcccaggaggaggaaccc
acagacccccagctgatgcggctggacaacatgctgttagcggaaggcgtggcggggcct
gagaagggcggagggtcggcggcagcggcggcagcggcggcggcttctggaggggcaggt
tcagacaactcagtggagcattcagattacagagccaaactctcacagatcagacaaatc
taccatacggagctggagaaatacgagcaggcctgcaacgagttcaccacccacgtgatg
aatctcctgcgagagcaaagccggaccaggcccatctccccaaaggagattgagcggatg
gtcagcatcatccaccgcaagttcagctccatccagatgcagctcaagcagagcacgtgc
gaggcggtgatgatcctgcgttcccgatttctggatgcgcggcggaagagacggaatttc
aacaagcaagcgacagaaatcctgaatgaatatttctattcccatctcagcaacccttac
cccagtgaggaagccaaagaggagttagccaagaagtgtggcatcacagtctcccaggta
tcaaactggtttggaaataagcgaatccggtacaagaagaacataggtaaatttcaagag
gaagccaatatttatgctgccaaaacagctgtcactgctaccaatgtgtcagcccatgga
agccaagctaactcgccctcaactcccaactcggctggttcttccagttcttttaacatg
tcaaactctggagatttgttcatgagcgtgcagtcactcaatggggattcttaccaaggg
gcccaggttggagccaacgtgcaatcacaggtggatacccttcgccatgttatcagccag
acaggaggatacagtgatggactcgcagccagtcagatgtacagtccgcagggcatcagt
gctaatggaggttggcaggatgctactaccccttcatcagtgacctcccctacagaaggc
cctggcagtgttcactctgatacctccaactga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Network (12)   
   KEGG NETWORK (12)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (21)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (18)   
DNA sequence (62)   
   RefSeq(nuc) (18)   
   GenBank (22)   
   EMBL (22)   
3D Structure (2)   
   PDB (2)   
Protein domain (8)   
   Pfam (8)   
All databases (127)   

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