KEGG T01001: 51366

Homo sapiens (human): 51366

Entry

51366 CDS T01001

Gene name

UBR5, DD5, EDD, EDD1, HYD

Definition

ubiquitin protein ligase E3 component n-recognin 5

Orthology

K10593

E3 ubiquitin-protein ligase EDD1 [EC:6.3.2.19]

Organism

hsa Homo sapiens (human)

Pathway

hsa04120

Ubiquitin mediated proteolysis

Class

Genetic Information Processing; Folding, sorting and degradation; Ubiquitin mediated proteolysis [PATH:hsa04120]

SSDB

Motif

Pfam:

HECT E3_UbLigase_EDD PABP zf-UBR

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

1I2T 2QHO 3PT3

Position

8q22

AA seq 2799 aa
MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAF
LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL
GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI
PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE
SYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP
LERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDL
QWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLT
NEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCA
LYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNP
LYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQ
EPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVE
DVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVK
TGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQ
ENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPP
ISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVV
LEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVE
AIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPP
IAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKD
RKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIA
KAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCG
LLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLT
ATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLE
PPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRL
DCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILS
VEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLA
STSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEE
QDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAA
ETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQ
SDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAAS
SAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMG
LIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALA
SAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNY
ALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTREL
LELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPF
EVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPT
KMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTE
SEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEV
KESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVT
FKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRER
EREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGER
LYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADS
ILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGK
NTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLR
QLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAE
HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES
GENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQ
HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV

NT seq 8400 nt +upstreamnt +downstreamnt
atgacgtccatccatttcgtggttcacccgctgccgggcaccgaggaccagctcaatgac
aggttacgagaagtttctgagaagctgaacaaatataatttaaacagccacccccctttg
aatgtattggaacaggctactattaaacagtgtgtggtgggaccaaatcatgctgccttt
cttcttgaggatggtagagtttgcaggattggtttttcagtacagccagacagattggaa
ttgggtaaacctgataataatgatgggtcaaagttgaacagcaactcgggggcagggagg
acgtcaaggcctggtaggacaagcgactctccatggtttctctcaggttctgagactcta
ggcaggctggcaggcaacaccttaggaagccgctggagttctggagtgggtggaagtggt
ggaggatcctctggtaggtcatcagctggagctcgagattcccgccggcagactcgagtt
attcggacaggacgggatcgagggtctgggcttttgggcagtcagccccagccagttatt
ccagcatctgtcattccagaggagctgatttcacaggcccaagttgttttacaaggcaaa
tccagaagtgtcattattcgagaacttcagagaacaaatcttgatgtgaaccttgctgta
aataatttacttagccgggatgatgaagatggagatgatggggatgatacagccagcgaa
tcttatttgcctggagaggatcttatgtctctccttgatgccgacattcattctgcccac
ccaagtgtcattattgatgcagatgccatgttttctgaagacattagctattttggttac
ccttcttttcgtcgttcatcactttccaggctaggctcatctcgagttctccttcttccc
ttagagagagactctgagctgttgcgtgaacgtgaatccgttttacgtttacgtgaacga
aggtggcttgatggagcctcatttgataatgaaaggggttctaccagcaaggaaggagag
ccaaacttggataagaagaatacacctgttcaaagtccagtatctctaggagaagatttg
cagtggtggcctgataaggatggaacaaaattcatctgtattggggctctgtattctgaa
cttctggctgtcagcagtaaaggagaactttatcagtggaaatggagtgaatctgagcct
tacagaaatgcccagaatccttcattacatcatccacgagcaacatttttggggttaacc
aatgaaaagatagtcctcctgtctgcaaatagcataagagcaactgtagctacagaaaat
aacaaggttgctacatgggtggatgaaactttaagttctgtggcttctaaattagagcac
actgctcagacttactctgaacttcaaggagagcggatagtttctttacattgctgtgcc
ctttacacctgcgctcagctggaaaacagtttatattggtggggtgtagttccttttagt
caaaggaagaaaatgttagagaaagctagagcaaaaaataaaaagcctaaatccagtgct
ggtatttcttcaatgccgaacatcactgttggtacccaggtatgcttgagaaataatcct
ctttatcatgctggagcagttgcattttcaattagtgctgggattcctaaagttggtgtc
ttaatggagtcagtttggaatatgaatgacagctgtagatttcaacttagatctcctgaa
agcttgaaaaacatggaaaaagctagcaaaactactgaagctaagcctgaaagtaagcag
gagccagtgaaaacagaaatgggtcctccaccatctccagcatccacgtgtagtgatgca
tcctcaattgccagcagtgcatcaatgccatacaaacgacgacggtcaacccctgcacca
aaagaagaggaaaaggtgaatgaagagcagtggtctcttcgggaagtggtttttgtggaa
gatgtcaagaatgttcctgttggcaaggtgctaaaagtagatggtgcctatgttgctgta
aaatttccaggaacctccagtaatactaactgtcagaacagctctggtccagatgctgac
ccttcttctctcctgcaggattgtaggttacttagaattgatgaattgcaggttgtcaaa
actggtggaacaccgaaggttcccgactgtttccaaaggactcctaaaaagctttgtata
cctgaaaaaacagaaatattagcagtgaatgtagattccaaaggtgttcatgctgttctg
aagactggaaattgggtacgatactgtatctttgatcttgctacaggaaaagcagaacag
gaaaataattttcctacaagcagcattgctttccttggtcagaatgagaggaatgtagcc
attttcactgctggacaggaatctcccattattcttcgagatggaaatggtaccatctac
ccaatggccaaagattgcatgggaggaataagggatcccgattggctggatcttccacct
attagtagtcttggaatgggtgtgcattctttaataaatcttcctgccaattcaacaatc
aaaaagaaagctgctgttatcatcatggctgtagagaaacaaaccttaatgcaacacatt
ctgcgctgtgactatgaggcctgtcgacaatatctaatgaatcttgagcaagcggttgtt
ttagagcagaatctacagatgctgcagacattcatcagccacagatgtgatggaaatcga
aatattttgcatgcttgtgtatcagtttgctttccaaccagcaataaagaaactaaagaa
gaagaggaagcggagcgttctgaaagaaatacatttgcagaaaggctttctgctgttgag
gccattgcaaatgcaatatcagttgtttcaagtaatggcccaggtaatcgggctggatca
tcaagtagccgaagtttgagattacgggaaatgatgagacgttcgttgagagcagctggt
ttgggtagacatgaagctggagcttcatccagtgaccaccaggatccagtttcacccccc
atagctccccctagttgggttcctgaccctcctgcgatggatcctgatggtgacattgat
tttatcctggcccccgctgtgggatctcttaccacagcagcaaccggtactggtcaagga
ccaagcacctccactattccaggtccttccacagagccatctgtagtagaatccaaggat
cgaaaggcgaatgctcattttatattgaaattgttatgtgacagtgtggttctccagccc
tatctacgagaacttctttctgccaaggatgcaagagggatgaccccatttatgtcagct
gtaagtggccgagcttatcctgctgcaattaccatcttagaaactgctcagaaaattgca
aaagctgaaatatcctcaagtgaaaaagaggaagatgtattcatgggaatggtttgccca
tcaggtaccaaccctgatgactctcctttatatgttttatgttgtaatgacacttgcagt
tttacatggactggagcagagcacattaaccaggatatttttgagtgtcgaacttgtggc
ttgctggagtcactgtgttgttgtacggaatgtgcaagggtttgtcataaaggtcatgat
tgcaaactcaaacggacatcaccaacagcctactgtgattgttgggagaaatgtaaatgt
aaaactcttattgctggacagaaatctgctcgtcttgatctactttatcgcctgctcact
gctactaatctggttactctgccaaacagcaggggagagcacctcttactattcttagta
cagacagtcgcaaggcagacggtggagcattgtcaatacaggccacctcgaatcagggaa
gatcgtaaccgaaaaacagccagtcctgaagattcagatatgccagatcatgatttagag
cctccaagatttgcccagcttgcattggagcgtgttctacaggactggaatgccttgaaa
tctatgattatgtttgggtcgcaggagaataaagaccctcttagtgccagcagtagaata
ggccatcttttgccagaagagcaagtatacctcaatcagcaaagtggcacaattcggctg
gactgtttcactcattgccttatagttaagtgtacagcagatattttgcttttagatact
ctactaggtacactagtgaaagaactccaaaacaaatatacacctggacgtagagaagaa
gctattgctgtgacaatgaggtttctacgttcagtggcaagagtttttgttattctgagt
gtggaaatggcttcatccaaaaagaaaaacaactttattccacagccaattggaaaatgc
aagcgtgtattccaagcattgctaccttacgctgtggaagaattgtgcaacgtagcagag
tcactgattgttcctgtcagaatggggattgctcgtccaactgcaccatttaccctggct
agtactagcatagatgccatgcagggcagtgaagaattattttcagtggaaccactacca
ccacgaccatcatctgatcagtctagcagctccagtcagtctcagtcatcctacatcatc
aggaatccacagcagaggcgcatcagccagtcacagcccgttcggggcagagatgaagaa
caggatgatattgtttcagcagatgtggaagaggttgaggtggtggagggtgtggctgga
gaagaggatcatcatgatgaacaggaagaacacggggaagaaaatgctgaggcagaggga
caacatgatgagcatgatgaagacgggagtgatatggagctggacttgttagcagcagct
gaaacagaaagtgatagtgaaagtaaccacagcaaccaagataatgctagtgggcgcaga
agcgttgtcactgcagcaactgctggttcagaagcaggagcaagcagtgttcctgccttc
ttttctgaagatgattctcaatcgaatgactcaagtgattctgatagcagtagtagtcag
agtgacgacatagaacaggagacctttatgcttgatgagccattagaaagaaccacaaat
agctcccatgccaatggtgctgcccaagctccccgttcaatgcagtgggctgtccgcaac
acccagcatcagcgagcagccagtacagccccttccagtacatctacaccagcagcaagt
tcagcgggtttgatttatattgatccttcaaacttacgccggagtggtaccatcagtaca
agtgctgcagctgcagcagctgctttggaagctagcaacgccagcagttacctaacatct
gcaagcagtttagccagggcttacagcattgtcattagacaaatctcggacttgatgggc
cttattcctaagtataatcacctagtatactctcagattccagcagctgtgaaattgact
taccaagatgcagtaaacttacagaactatgtagaagaaaagcttattcccacttggaac
tggatggtcagtattatggattctactgaagctcaattacgttatggttctgcattagca
tctgctggtgatcctggacatccaaatcatcctcttcacgcttctcagaattcagcgaga
agagagaggatgactgcgcgagaagaagctagcttacgaacacttgaaggcagacgacgt
gccaccttgcttagcgcccgtcaaggaatgatgtctgcacgaggagacttcctaaattat
gctctgtctctaatgcggtctcataatgatgagcattctgatgttcttccagttttggat
gtttgctcattgaagcatgtggcatatgtttttcaagcacttatatactggattaaggca
atgaatcagcagacaacattggatacacctcaactagaacgcaaaaggacgcgagaactc
ttggaactgggtattgataatgaagattcagaacatgaaaatgatgatgacaccaatcaa
agtgctactttgaatgataaggatgatgactctcttcctgcagaaactggccaaaaccat
ccatttttccgacgttcagactccatgacattccttgggtgtatacccccaaatccattt
gaagtgcctctggctgaagccatccccttggctgatcagccacatctgttgcagccaaat
gctagaaaggaggatctttttggccgtccaagtcagggtctttattcttcatctgccagt
agtgggaaatgtttaatggaggttacagtggatagaaactgcctagaggttcttccaaca
aaaatgtcttatgctgccaatctgaaaaatgtaatgaacatgcaaaaccggcaaaaaaaa
gaaggggaagaacagcccgtgctgccagaagaaactgagagttcaaaaccagggccatct
gctcatgatcttgctgcacaattaaaaagtagcttactagcagaaataggacttactgaa
agtgaagggccacctctcacatctttcaggccacagtgtagctttatgggaatggttatt
tcccatgatatgctgctaggacgttggcgcctttctttagaactgttcggcagggtattc
atggaagatgttggagcagaacctggatcaatcctaactgaattgggtggttttgaggta
aaagaatcaaaattccgcagagaaatggaaaaactgagaaaccagcagtcaagagatttg
tcactagaggttgatcgggatcgagatcttctcattcagcagactatgaggcagcttaac
aatcactttggtcgaagatgtgctactacaccaatggctgtacacagagtaaaagtcaca
tttaaggatgagccaggagagggcagtggtgtagcacgaagtttttatacagccattgca
caagcatttttatcaaatgaaaaattgccaaatctagagtgtatccaaaatgccaacaaa
ggcacccacacaagtttaatgcagagattaaggaaccgaggagagagagaccgggaaagg
gagagagaaagggaaatgaggaggagtagtggtttgcgagcaggttctcggagggaccgg
gatagagactttagaagacagctttccatcgacactaggccctttagaccagcctctgaa
gggaatcctagcgatgatcctgagcctttgccagcacatcggcaggcacttggagagagg
ctttatcctcgtgtacaagcaatgcaaccagcatttgcaagtaaaatcactggcatgttg
ttggaattatccccagctcagctgcttctccttctagcaagtgaggattctctgagagca
agagtggatgaggccatggaactcattattgcacatggacgggaaaatggagctgatagt
atcctggatcttggattagtagactcctcagaaaaggtacagcaggaaaaccgaaagcgc
catggctctagtcgaagtgtagtagatatggatttagatgatacagatgatggtgatgac
aatgcccctttgttttaccaacctgggaaaagaggattttatactccaaggcctggcaag
aacacagaagcaaggttgaattgtttcagaaacattggcaggattcttggactatgtctg
ttacagaatgaactatgtcctatcacattgaatagacatgtaattaaagtattgcttggt
agaaaagtcaattggcatgattttgctttttttgatcctgtaatgtatgagagtttgcgg
caactaatcctcgcgtctcagagttcagatgctgatgctgttttctcagcaatggatttg
gcatttgcaattgacctgtgtaaagaagaaggtggaggacaggttgaactcattcctaat
ggtgtaaatataccagtcactccacagaatgtatatgagtatgtgcggaaatacgcagaa
cacagaatgttggtagttgcagaacagcccttacatgcaatgaggaaaggtctactagat
gtgcttccaaaaaattcattagaagatttaacggcagaagattttaggcttttggtaaat
ggctgcggtgaagtcaatgtgcaaatgctgatcagttttacctctttcaatgatgaatca
ggagaaaatgctgagaagcttctgcagttcaagcgttggttctggtcaatagtagagaag
atgagcatgacagaacgacaagatcttgtttacttttggacatcaagcccatcactgcca
gccagtgaagaaggattccagcctatgccctcaatcacaataagaccaccagatgaccaa
catcttcctactgcaaatacttgcatttctcgactttacgtcccactctattcctctaaa
cagattctcaaacagaaattgttactcgccattaagaccaagaattttggttttgtgtag

All links

Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (7)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (25)   
   RefSeq(nuc) (1)   
   GenBank (12)   
   EMBL (12)   
3D Structure (3)   
   PDB (3)   
Protein domain (4)   
   Pfam (4)   
All databases (53)   

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