| Entry |
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| Gene name |
PDE4C, DPDE1
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| Definition |
phosphodiesterase 4C, cAMP-specific (EC:3.1.4.17)
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| Orthology |
| 3',5'-cyclic-nucleotide phosphodiesterase [EC: 3.1.4.17] |
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| Organism |
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| Pathway |
| Purine metabolism | | Morphine addiction |
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| Drug target |
Papaverine: Moxaverine: Trapidil: Flavoxate: Caffeine: Propentofylline: Choline theophyllinate: Proxyphylline: Theophylline: Aminophylline: Doxofylline: Ibudilast: Roflumilast: Other: |
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| Class |
Metabolism; Nucleotide metabolism; Purine metabolism [PATH: hsa00230]
Human Diseases; Substance dependence; Morphine addiction [PATH: hsa05032]
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| SSDB |
   |
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| Motif |
 |
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| Other DBs |
NCBI-GI: NCBI-GeneID: OMIM: HGNC: HPRD: Ensembl: Vega: UniProt: |
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| Structure |
PDB: |
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| Position |
19p13.11
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| AA seq |
712 aa  
MENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERD
LSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESF
LYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGA
AKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRI
LNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSA
SLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLL
KTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILA
ALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNL
SAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQN
LVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGF
IDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFEL
TLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT |
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| NT seq |
2139 nt  +upstreamnt +downstreamnt
atggagaacctgggggtcggcgaaggggcagaggcttgcagcaggttgagtcgctctcgc
ggccgccacagcatgaccagagccccgaagcacctgtggcggcaaccccggcgccccatc
cgcatccaacagcgcttctattcggatccggacaagtccgcgggctgccgcgagagggac
ctgagcccgcggccggagctcaggaagtcgcggctctcctggcccgtttcctcctgcagg
cgctttgacctggaaaatgggctctcgtgtgggaggagggccctggaccctcagtccagc
cctggcctgggccggattatgcaggctccagtcccgcacagccagcggcgcgagtccttc
ctgtaccgctcagatagcgactatgaactctcgcccaaggccatgtctcggaactcctct
gtggccagcgacctacatggagaggacatgattgtgacgccctttgcccaggtcctggcc
agtctgcggaccgttcggagcaacgtggcggcccttgcccgccagcaatgcctaggagca
gccaagcagggacccgtcggaaacccttcatccagcaatcagctccctcctgcagaggac
acggggcagaagctggcattggagacgctagacgagctggactggtgcctggatcagttg
gagacgctgcagacccggcactcggtgggggagatggcctccaacaagttcaagcggatc
ctgaaccgggagttgacccacctgtccgaaaccagccgctccgggaaccaggtgtccgag
tacatctcccggaccttcctggaccagcagaccgaggtggagctgcccaaggtgaccgct
gaggaggccccacagcccatgtcccggatcagtggcctacatgggctctgccacagtgcc
agcctctcctcagccactgtcccacgctttggggtccagactgaccaggaggagcaactg
gccaaggagctagaagacaccaacaagtggggacttgatgtgttcaaggtggcggagcta
agtgggaaccggcccctcacagctatcatattcagcatttttcaggagcgggacctgctg
aagacattccagatcccagcagacacactggccacctacctgctgatgctggaaggtcac
taccacgccaatgtggcctaccacaacagcctacatgccgccgacgtggcccagtccacg
catgtgctgctggctacgcccgccctcgaggctgtgttcacagacttggaaatcctggct
gccctctttgcaagcgccatccacgacgtggaccatcctggggtctccaaccagtttctg
attaacaccaactcagagctggcgcttatgtacaacgacgcctcggtgctggagaaccat
cacctggctgtgggcttcaagctgctgcaggcagagaactgcgatatcttccagaacctc
agcgccaagcagcgactgagtctgcgcaggatggtcattgacatggtgctggccacagac
atgtccaaacacatgaacctcctggccgacctcaagaccatggtggagaccaagaaggtg
acaagcctcggtgtcctcctcctggacaactattccgaccgaatccaggtcttgcagaac
ctggtgcactgtgctgatctgagcaaccccaccaagccgctgcccctgtaccgccagtgg
acggaccgcatcatggccgagttcttccagcagggagaccgcgagcgtgagtcgggcctg
gacatcagtcccatgtgtgacaagcatacggcctcagtggagaagtcccaggtgggtttc
attgactacattgctcacccactgtgggagacttgggctgacctggtccacccagatgca
caggacctgctggacacgctggaggacaatcgagagtggtaccagagcaagatcccccga
agtccctcagacctcaccaaccccgagcgggacgggcctgacagattccagtttgaactg
actctggaggaggcagaggaagaggatgaggaggaagaagaggagggggaagagacagct
ttagccaaagaggccttggagttgcctgacactgaactcctgtcccctgaagccggccca
gaccctggggacttacccctcgacaaccagaggacttag |
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