KEGG   Homo sapiens (human): 5207Help
Entry
5207              CDS       T01001                                 

Gene name
PFKFB1, F6PK, HL2K, PFRX
Definition
(RefSeq) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
  KO
K19028  6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 1 [EC:2.7.1.105 3.1.3.46]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00051  Fructose and mannose metabolism
hsa04152  AMPK signaling pathway
hsa04922  Glucagon signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Carbohydrate metabolism
   00051 Fructose and mannose metabolism
    5207 (PFKFB1)
 Environmental Information Processing
  Signal transduction
   04152 AMPK signaling pathway
    5207 (PFKFB1)
 Organismal Systems
  Endocrine system
   04922 Glucagon signaling pathway
    5207 (PFKFB1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.105  6-phosphofructo-2-kinase
     5207 (PFKFB1)
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.46  fructose-2,6-bisphosphate 2-phosphatase
     5207 (PFKFB1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 6PF2K His_Phos_1 AAA_33 Zeta_toxin KTI12
Motif
Other DBs
NCBI-GeneID: 5207
NCBI-ProteinID: NP_002616
OMIM: 311790
HGNC: 8872
Ensembl: ENSG00000158571
Vega: OTTHUMG00000021643
Pharos: P16118(Tbio)
UniProt: P16118
Structure
PDB: 

Jmol
Position
Xp11.21
AA seq 471 aa AA seqDB search
MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYIST
KLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYL
SHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPD
YIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRT
VYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLK
VWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRY
RYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLH
TVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY
NT seq 1416 nt NT seq  +upstreamnt  +downstreamnt
atgtctccagagatgggagagctcacccaaaccaggttgcagaagatctggattccacac
agcagcggcagcagcaggctgcaacggagaaggggctcatccataccccagtttaccaat
tcccccacaatggtgatcatggtgggtttaccagctcgaggcaagacctatatctccaca
aagctcacacgatatctcaactggataggaacaccaactaaagtgtttaatttaggccag
tatcgacgagaggcagtgagctacaagaactatgaattctttcttccagacaacatggaa
gccctgcaaatcaggaagcagtgcgccctggcagccctgaaggatgttcacaactatctc
agccatgaggaaggtcatgttgcggtttttgatgccaccaacactaccagagaacgacgg
tcactgatcctgcagtttgcaaaagaacatggttacaaggtgtttttcattgagtccatt
tgtaatgaccctggcataattgcagaaaacatcaggcaagtgaaacttggcagccctgat
tatatagactgtgaccgggaaaaggttctggaagactttctaaagagaattgagtgctat
gaggtcaactaccaacccttggatgaggaactggacagccacctgtcctacatcaagatc
ttcgacgtgggcacacgctacatggtgaaccgagtgcaggatcacatccagagccgcaca
gtctactacctcatgaatatccatgtcacacctcgctccatctacctttgccgacatggc
gagagtgaactcaacatcagaggccgcatcggaggtgactctggcctctcagttcgcggc
aagcagtatgcctatgccctggccaacttcattcagtcccagggcatcagctccctgaag
gtgtggaccagtcacatgaagaggaccatccagacagctgaggccctgggtgtcccctat
gagcagtggaaggccctgaatgagattgatgcgggtgtctgtgaggagatgacctatgaa
gaaatccaggaacattaccctgaagaatttgcactgcgagaccaagataaatatcgctac
cgctatcccaagggagagtcctatgaggatctggttcagcgtctggagccagtgataatg
gagctagaacgacaggagaatgtactggtgatctgccaccaggctgtcatgcggtgcctc
ctggcctatttcctggataaaagttcagatgagcttccatatctcaagtgccctctgcac
acagtgctcaaactcactcctgtggcttatggctgcaaagtggaatccatctacctgaat
gtggaggccgtgaacacacaccgggagaagcctgagaatgtggacatcacccgggaacct
gaggaagccctggatactgtcccagcccactactga

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