| Entry |
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| Gene name |
PKLR, PK1, PKL, PKR, PKRL, RPK
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| Definition |
pyruvate kinase, liver and RBC (EC:2.7.1.40)
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| Orthology |
| pyruvate kinase isozymes R/L [EC: 2.7.1.40] |
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| Organism |
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| Pathway |
| Glycolysis / Gluconeogenesis | | Purine metabolism | | Pyruvate metabolism | | Metabolic pathways | | Biosynthesis of amino acids | | Insulin signaling pathway | | Type II diabetes mellitus | | Maturity onset diabetes of the young |
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| Module |
| Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate | | Glycolysis, core module involving three-carbon compounds | | Adenine ribonucleotide biosynthesis, IMP => ADP,ATP | | Guanine ribonucleotide biosynthesis IMP => GDP,GTP |
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| Disease |
| Pyruvate kinase (PK) deficiency |
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| Class |
Metabolism; Carbohydrate metabolism; Glycolysis / Gluconeogenesis [PATH: hsa00010]
Metabolism; Carbohydrate metabolism; Pyruvate metabolism [PATH: hsa00620]
Metabolism; Nucleotide metabolism; Purine metabolism [PATH: hsa00230]
Organismal Systems; Endocrine system; Insulin signaling pathway [PATH: hsa04910]
Human Diseases; Endocrine and metabolic diseases; Type II diabetes mellitus [PATH: hsa04930]
Human Diseases; Endocrine and metabolic diseases; Maturity onset diabetes of the young [PATH: hsa04950]
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| SSDB |
   |
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| Motif |
 |
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| Other DBs |
NCBI-GI: NCBI-GeneID: OMIM: HGNC: HPRD: Ensembl: Vega: UniProt: |
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| Structure |
PDB: |
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| Position |
1q21
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| AA seq |
574 aa  
MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQ
LPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFS
HGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKG
SQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQV
ENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAA
LGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRC
NLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKM
QHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRS
AQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESG
KLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS |
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| NT seq |
1725 nt  +upstreamnt +downstreamnt
atgtcgatccaggagaacatatcatccctgcagcttcggtcatgggtctctaagtcccaa
agagacttagcaaagtccatcctgattggggctccaggagggccagcggggtatctgcgg
cgggccagtgtggcccaactgacccaggagctgggcactgccttcttccagcagcagcag
ctgccagctgctatggcagacaccttcctggaacacctctgcctactggacattgactcc
gagcccgtggctgctcgcagtaccagcatcattgccaccatcgggccagcatctcgctcc
gtggagcgcctcaaggagatgatcaaggccgggatgaacattgcgcgactcaacttctcc
cacggctcccacgagtaccatgctgagtccatcgccaacgtccgggaggcggtggagagc
tttgcaggttccccactcagctaccggcccgtggccatcgccctggacaccaagggaccg
gagatccgcactgggatcctgcaggggggtccagagtcggaagtggagctggtgaagggc
tcccaggtgctggtgactgtggaccccgcgttccggacgcgggggaacgcgaacaccgtg
tgggtggactaccccaatattgtccgggtcgtgccggtggggggccgcatctacattgac
gacgggctcatctccctagtggtccagaaaatcggcccagagggactggtgacccaagtg
gagaacggcggcgtcctgggcagccggaagggcgtgaacttgccaggggcccaggtggac
ttgcccgggctgtccgagcaggacgtccgagacctgcgcttcggggtggagcatggggtg
gacatcgtctttgcctcctttgtgcggaaagccagcgacgtggctgccgtcagggctgct
ctgggtccggaaggacacggcatcaagatcatcagcaaaattgagaaccacgaaggcgtg
aagaggtttgatgaaatcctggaggtgagcgacggcatcatggtggcacggggggaccta
ggcatcgagatcccagcagagaaggttttcctggctcagaagatgatgattgggcgctgc
aacttggcgggcaagcctgttgtctgtgccacacagatgctggagagcatgattaccaag
ccccggccaacgagggcagagacaagcgatgtcgccaatgctgtgctggatggggctgac
tgcatcatgctgtcaggggagactgccaagggcaacttccctgtggaagcggtgaagatg
cagcatgcgattgcccgggaggcagaggccgcagtgtaccaccggcagctgtttgaggag
ctacgtcgggcagcgccactaagccgtgatcccactgaggtcaccgccattggtgctgtg
gaggctgccttcaagtgctgtgctgctgccatcattgtgctgaccacaactggccgctca
gcccagcttctgtctcggtaccgacctcgggcagcagtcattgctgtcacccgctctgcc
caggctgcccgccaggtccacttatgccgaggagtcttccccttgctttaccgtgaacct
ccagaagccatctgggcagatgatgtagatcgccgggtgcaatttggcattgaaagtgga
aagctccgtggcttcctccgtgttggagacctggtgattgtggtgacaggctggcgacct
ggctccggctacaccaacatcatgcgggtgctaagcatatcctga |
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